ID A0A2K5VAA2_MACFA Unreviewed; 669 AA.
AC A0A2K5VAA2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Amiloride-sensitive sodium channel subunit alpha {ECO:0000256|ARBA:ARBA00040202};
DE AltName: Full=Alpha-NaCH {ECO:0000256|ARBA:ARBA00042253};
DE AltName: Full=Epithelial Na(+) channel subunit alpha {ECO:0000256|ARBA:ARBA00041738};
DE AltName: Full=Nonvoltage-gated sodium channel 1 subunit alpha {ECO:0000256|ARBA:ARBA00043048};
DE AltName: Full=SCNEA {ECO:0000256|ARBA:ARBA00041933};
GN Name=SCNN1A {ECO:0000313|Ensembl:ENSMFAP00000021674.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000021674.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000021674.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000021674.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004424}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasmic granule
CC {ECO:0000256|ARBA:ARBA00004463}. Cytoplasmic vesicle, secretory
CC vesicle, acrosome {ECO:0000256|ARBA:ARBA00004218}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. SCNN1A subfamily. {ECO:0000256|ARBA:ARBA00037944}.
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DR AlphaFoldDB; A0A2K5VAA2; -.
DR STRING; 9541.ENSMFAP00000021674; -.
DR Ensembl; ENSMFAT00000034343.2; ENSMFAP00000021674.2; ENSMFAG00000035743.2.
DR VEuPathDB; HostDB:ENSMFAG00000035743; -.
DR GeneTree; ENSGT00940000160952; -.
DR OrthoDB; 5344287at2759; -.
DR Proteomes; UP000233100; Chromosome 11.
DR Bgee; ENSMFAG00000035743; Expressed in adult mammalian kidney and 4 other cell types or tissues.
DR GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF124; AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022480};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 75706 MW; 8F4FFCFBFB9B18FF CRC64;
MEGNKLEEQD ASPPQPTPGL MKGDKREEQG LGPEPAAPQQ PTAEEEALIE FHRSYRELFE
FFCNNTTIHG AIRLVCSQHN RMKTAFWAVL WLCTFGMMYW QFGLLFGEYF SYPVSLNINL
NSDKLVFPAV TICTLNPYRY PEIKEELEEL DRITQQTLFD LYKYDSSPTL VAGSRGRRDL
RGTLPHLLQR LRVPSPLHGA RQARSVASSV RDNNPQVDWK DWKIGFELCN QNKSDCFYQT
YSSGVDAVRE WYRFHYINIL SRLPEALPSL EEDTLGNFIF ACRFNQVSCN QANYSHFHHP
MYGNCYTFND KNNSNLWMSS MPGVNNGLSL MLRTEQNDFI PLLSTVTGAR VMVHGQDEPA
FMDDGGFNLR PGVETSISMR KEALDRLGGD YGDCTKNGSD VPVKNLYPSK YTQQVCIHSC
FQENMIKECG CAYIFYPRPQ NMEYCDYRKH SSWGYCYYKL QADFSSDHLG CFTKCRKPCS
VTSYQLSAGY SRWPSVTSQE WVFEMLSRQN NYTINNKRNG VAKVNIFFKE LNYKTNSESP
SVTMVTLLSN LGSQWSLWFG SSVLSVVEMA ELIFDLLVIT FLLLLRRFRS RYWSPGRGDR
GAQEVASTQA SSPPSHFCPH PTSLYLSQLG PAPSPALTAP PPAYATLGPC PSPGGSAGAS
STAYPLGGP
//
