ID A0A2K5VAR2_MACFA Unreviewed; 291 AA.
AC A0A2K5VAR2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Kidney mitochondrial carrier protein 1 {ECO:0000256|ARBA:ARBA00040654};
DE AltName: Full=Solute carrier family 25 member 30 {ECO:0000256|ARBA:ARBA00041892};
GN Name=SLC25A30 {ECO:0000313|Ensembl:ENSMFAP00000021800.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000021800.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000021800.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000021800.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) +
CC sulfate(in); Xref=Rhea:RHEA:73403, ChEBI:CHEBI:16189,
CC ChEBI:CHEBI:30924; Evidence={ECO:0000256|ARBA:ARBA00035985};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) +
CC sulfate(in); Xref=Rhea:RHEA:73227, ChEBI:CHEBI:16189,
CC ChEBI:CHEBI:30934; Evidence={ECO:0000256|ARBA:ARBA00035807};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) +
CC sulfate(in); Xref=Rhea:RHEA:73223, ChEBI:CHEBI:16189,
CC ChEBI:CHEBI:30936; Evidence={ECO:0000256|ARBA:ARBA00036130};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in);
CC Xref=Rhea:RHEA:71615, ChEBI:CHEBI:15589, ChEBI:CHEBI:16189;
CC Evidence={ECO:0000256|ARBA:ARBA00037004};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate(out) = (S)-malate(in); Xref=Rhea:RHEA:74555,
CC ChEBI:CHEBI:15589; Evidence={ECO:0000256|ARBA:ARBA00036759};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) +
CC sulfate(in); Xref=Rhea:RHEA:73407, ChEBI:CHEBI:16189,
CC ChEBI:CHEBI:30927; Evidence={ECO:0000256|ARBA:ARBA00036586};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-aspartate(in) + sulfate(out) = D-aspartate(out) +
CC sulfate(in); Xref=Rhea:RHEA:73399, ChEBI:CHEBI:16189,
CC ChEBI:CHEBI:29990; Evidence={ECO:0000256|ARBA:ARBA00036479};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-aspartate(in) + sulfate(out) = L-aspartate(out) +
CC sulfate(in); Xref=Rhea:RHEA:73395, ChEBI:CHEBI:16189,
CC ChEBI:CHEBI:29991; Evidence={ECO:0000256|ARBA:ARBA00036015};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=maleate(in) + sulfate(out) = maleate(out) + sulfate(in);
CC Xref=Rhea:RHEA:73199, ChEBI:CHEBI:16189, ChEBI:CHEBI:30780;
CC Evidence={ECO:0000256|ARBA:ARBA00035765};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=malonate(in) + sulfate(out) = malonate(out) + sulfate(in);
CC Xref=Rhea:RHEA:73195, ChEBI:CHEBI:15792, ChEBI:CHEBI:16189;
CC Evidence={ECO:0000256|ARBA:ARBA00036751};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in);
CC Xref=Rhea:RHEA:72275, ChEBI:CHEBI:16189, ChEBI:CHEBI:30623;
CC Evidence={ECO:0000256|ARBA:ARBA00036514};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=phosphate(in) + sulfate(out) = phosphate(out) + sulfate(in);
CC Xref=Rhea:RHEA:71631, ChEBI:CHEBI:16189, ChEBI:CHEBI:43474;
CC Evidence={ECO:0000256|ARBA:ARBA00036861};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=phosphate(in) = phosphate(out); Xref=Rhea:RHEA:32823,
CC ChEBI:CHEBI:43474; Evidence={ECO:0000256|ARBA:ARBA00036616};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=succinate(in) + sulfate(out) = succinate(out) + sulfate(in);
CC Xref=Rhea:RHEA:73411, ChEBI:CHEBI:16189, ChEBI:CHEBI:30031;
CC Evidence={ECO:0000256|ARBA:ARBA00036691};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=sulfate(in) = sulfate(out); Xref=Rhea:RHEA:34983,
CC ChEBI:CHEBI:16189; Evidence={ECO:0000256|ARBA:ARBA00035907};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=sulfate(out) + sulfite(in) = sulfate(in) + sulfite(out);
CC Xref=Rhea:RHEA:73207, ChEBI:CHEBI:16189, ChEBI:CHEBI:17359;
CC Evidence={ECO:0000256|ARBA:ARBA00036232};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=sulfate(out) + thiosulfate(in) = sulfate(in) +
CC thiosulfate(out); Xref=Rhea:RHEA:73215, ChEBI:CHEBI:16189,
CC ChEBI:CHEBI:33542; Evidence={ECO:0000256|ARBA:ARBA00036708};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR RefSeq; XP_015294731.1; XM_015439245.1.
DR AlphaFoldDB; A0A2K5VAR2; -.
DR Ensembl; ENSMFAT00000029927.2; ENSMFAP00000021800.2; ENSMFAG00000035809.2.
DR GeneID; 101925739; -.
DR KEGG; mcf:101925739; -.
DR CTD; 253512; -.
DR VEuPathDB; HostDB:ENSMFAG00000035809; -.
DR GeneTree; ENSGT00940000158961; -.
DR Proteomes; UP000233100; Chromosome 17.
DR Bgee; ENSMFAG00000035809; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:Ensembl.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR002067; Mit_carrier.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45618:SF11; KIDNEY MITOCHONDRIAL CARRIER PROTEIN 1; 1.
DR PANTHER; PTHR45618; MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR PRINTS; PR00784; MTUNCOUPLING.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT REPEAT 7..96
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 104..189
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 198..289
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 291 AA; 32422 MW; D39154182EB07622 CRC64;
MSALNWKPFV YGGLASITAE CGTFPIDLTK TRLQIQGQTN DAKFKEIRYR GMLHALVRIG
REEGLKALYS GIAPAMLRQA SYGTIKIGTY QSLKRLFVER PEDETLLINV ICGILSGVIS
STIANPTDVL KIRMQAQSST IQGGMIGNFM NIYQQEGTRG LWKGVSLTAQ RAAIVVGVEL
PVYDITKKHL ILSGLMGDTV YTHFLSSFTC GLAGALASNP VDVVRTRMMN QRVLQDGRCS
GYTGTLDCLL QTWKNEGFFA LYKGFWPNWL RLGPWNIIFF VTYEQLKKLD L
//
