ID A0A2K5VCW2_MACFA Unreviewed; 574 AA.
AC A0A2K5VCW2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=RAS guanyl releasing protein 4 {ECO:0000313|Ensembl:ENSMFAP00000022557.2};
GN Name=RASGRP4 {ECO:0000313|Ensembl:ENSMFAP00000022557.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000022557.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000022557.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000022557.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RASGRP family.
CC {ECO:0000256|ARBA:ARBA00009566}.
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DR AlphaFoldDB; A0A2K5VCW2; -.
DR Ensembl; ENSMFAT00000030686.2; ENSMFAP00000022557.2; ENSMFAG00000040225.2.
DR VEuPathDB; HostDB:ENSMFAG00000040225; -.
DR GeneTree; ENSGT00940000159883; -.
DR Proteomes; UP000233100; Chromosome 19.
DR Bgee; ENSMFAG00000040225; Expressed in bone marrow and 4 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF157; RAS GUANYL-RELEASING PROTEIN 4; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 49..175
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 95..333
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 367..402
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 441..491
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 63880 MW; 89851B892969FD97 CRC64;
MNRKDSKRKS HQECTGKTGG RGRPRQTRRH KTCPSPREIS KVMASMNLGL LSEGGCSEDE
LLEKCIQSFD SAGSLCHGDH MLNMVLAMHS WVLPSADLAA RLLTLYQKAT GDTQELRRLQ
ICHLVRYWLT QHPEVMHQDP QLEEVIGCFW ATVAQEGNSA QRNLRDSSNL LSPGGPGPPP
SSPGLGKKRK VSLLFDHLET GELAQHLTYL EFRSFQAITA LLELTEILAS HNNYARYRRT
WAGCTGFRLP VLGVHLKDLV SLHEAQPDRL PDGRLHLPKL NNLYLRLQEL VALQGQHPPC
SANEDLLHLL TLSLDLFYTE DEIYELSYAR EPRCPKSLPP SPFNAPLVVE WAPGVTPKPD
RVTLGRHVEQ LVESVFKNYD PEGRGTISQE DFERLSGNFP FACHGLHPPP RQGRGSFSRE
ELTGYLLRAS AICSKLGLAF LHTFHEVTFR KPTFCDSCSG FLWGVTKQGY RCRECGLCCH
RHCRDQVKVE CKKRPGGKGD AGPPGAPVPC TPAPHASCGS EENLSYTLSL EPETGCQLRH
AWTQTESPHP SWETDTVPCP VMGPPSTASS KPDS
//
