ID A0A2K5VDC4_MACFA Unreviewed; 758 AA.
AC A0A2K5VDC4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Potassium channel tetramerization domain containing 3 {ECO:0000313|Ensembl:ENSMFAP00000022724.2};
GN Name=KCTD3 {ECO:0000313|Ensembl:ENSMFAP00000022724.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000022724.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000022724.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000022724.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the KCTD3 family.
CC {ECO:0000256|ARBA:ARBA00009572}.
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DR AlphaFoldDB; A0A2K5VDC4; -.
DR Ensembl; ENSMFAT00000030854.2; ENSMFAP00000022724.2; ENSMFAG00000042976.2.
DR VEuPathDB; HostDB:ENSMFAG00000042976; -.
DR GeneTree; ENSGT00940000153881; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000042976; Expressed in colon and 13 other cell types or tissues.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18393; BTB_POZ_SHKBP1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR047876; SHKBP1/KCTD3.
DR InterPro; IPR047825; SHKBP1_KCTD3_BTB_POZ.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR15859:SF2; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD3; 1.
DR PANTHER; PTHR15859; SETA BINDING PROTEIN 1; 1.
DR Pfam; PF02214; BTB_2; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50097; BTB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 18..87
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 139..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 82879 MW; 7C765B4DC4F72E78 CRC64;
MAGGHCGSFA AAAAGSGEIV QLNVGGTRFS TSRQTLMWIP DSFFSSLLSG RISTLRDETG
AIFIDRDPAA FAPILNFLRT KELDLRGVSI NVLRHEAEFY GITPLVRRLL LCEELERSSC
GSVLFHGYLP PPGIPSRKIN NTVRSADSRN GLNSTEGEAR GNGTQPVLSG TGEETVRLGF
PVDPRKVLIV AGHHNWIVAA YAHFAVCYRI KESSGWQQVF TSPYLDWTIE RVALNAKVVG
GPHGDKDKMV AVASESSIIL WSVQDGGSGS EIGVFSLGVP VDALFFIGNQ LVATSHTGKV
GVWNAVTQHW QVQDVVPITS YDTAGSFLLL GCNNGSIYYI DMQKFPLRMK DNDLLVTELY
HDPSNDAITA LSVYLTPKTI CADNNHVRTW TVTRFRGMIS TQPGSTPLAS FKILSLEETE
SHGSYSSGND IGPFGERDDQ QVFIQKVVPI TNKLFVRLSS TGKRICEIQA VDCTTISSFT
VRECEGSSRM GSRPRRYLFT GHTNGSIQMW DLTTAMDMVN KSEDKDVGGP TEEELLKLLD
QCDLSTSRCA TPNISPATSV VQHSHLRESN SSLQLQHHDT IHEAATYGSM RPYRESPLLA
RARRTESFHS YRDFQTINLN RNVERAVPEN GNLGPIQAEV KGVTGECNIS ERKSPGVEIK
SLRELDSGLE VHKVAEGFSE SKKRSSEDEN ENKIEFRKKG GFEGGGFLGR KKVPYLVSSP
STSDGGTDSP GTASPSPTKT TPSPRHKKSD SSGQEYSL
//
