ID A0A2K5VEY7_MACFA Unreviewed; 750 AA.
AC A0A2K5VEY7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=ADAM metallopeptidase domain 32 {ECO:0000313|Ensembl:ENSMFAP00000023268.2};
GN Name=ADAM32 {ECO:0000313|Ensembl:ENSMFAP00000023268.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000023268.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000023268.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000023268.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A2K5VEY7; -.
DR Ensembl; ENSMFAT00000031401.2; ENSMFAP00000023268.2; ENSMFAG00000043270.2.
DR VEuPathDB; HostDB:ENSMFAG00000043270; -.
DR GeneTree; ENSGT00940000161015; -.
DR Proteomes; UP000233100; Chromosome 8.
DR Bgee; ENSMFAG00000043270; Expressed in lung and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 4.10.70.10; Disintegrin domain; 1.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR018358; Disintegrin_CS.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001590; Peptidase_M12B.
DR InterPro; IPR002870; Peptidase_M12B_N.
DR InterPro; IPR034027; Reprolysin_adamalysin.
DR PANTHER; PTHR11905; ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN; 1.
DR PANTHER; PTHR11905:SF24; DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 32; 1.
DR Pfam; PF08516; ADAM_CR; 1.
DR Pfam; PF00200; Disintegrin; 1.
DR Pfam; PF01562; Pep_M12B_propep; 1.
DR Pfam; PF01421; Reprolysin; 1.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; Blood coagulation inhibitor (disintegrin); 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50215; ADAM_MEPRO; 1.
DR PROSITE; PS00427; DISINTEGRIN_1; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..750
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030051489"
FT TRANSMEM 690..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 192..389
FT /note="Peptidase M12B"
FT /evidence="ECO:0000259|PROSITE:PS50215"
FT DOMAIN 397..485
FT /note="Disintegrin"
FT /evidence="ECO:0000259|PROSITE:PS50214"
FT DOMAIN 628..661
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 345..350
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00276"
FT DISULFID 651..660
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 750 AA; 84375 MW; 20CF8BF6967C92CD CRC64;
TIFLFFILSY LQGILSWKPN NFSFQNSLLQ IVIPEKIQTN TSDGSEIEYE QISYIIPIDE
KPYTVHLKQR YFLADNFMIY LYDQGSMNAR SSDIQTQCYY QGNIEGYPDS MVTLSTCSGL
RLGILQFENV SYAIEPLESA VEFQHVLYKL DNEDNDIAIF SENNRSLEEH PMDDNISISE
QSEPAVPDLF PLYLEMHIVV DKALYDYWGS DSMVVTNKVI EIVGLANSMF AQFKVTIVLS
SLEVWSDENK ISTVGEADEL LKRFLEWKQS YLNLRPHDIA YLLIYRDYPD YVGATFPGKM
CITRYSAGVA LYPKEITLEA FSVIVTQMLA LSLGISYDDP KKCRCSESIC IMNPEALQSN
GVKTFSSCSL RSFQNFISNV GAKCLQNKPQ MQGKSPKPVC GNGRLEGSEM CDCGTEAQCG
PASCCDFRTC VLKDGAQCYR GSCCRDCQIL QSGVECRPKA HPECDIAENC NGSSPECGPD
ITLFNGLPCK NSKFICYDGD CHDLDARCES VFGKGSRNAP FACYEEIQSQ ADRFGNCGRD
RNNKYVFCGW RNLICGRLVC TYPTRKPFHQ ENGDVIYAFV RDSVCVTVDY KLPRTVPDPL
TVKNGSQCDV GRICVNRQCV ESRKIKATAL VCSEYTCSGH GVCDSRQKCV CSPGYNPPSC
QTRSKGFPIF PKEDMDSIME RASGKTENTW LLGFSVVLPI LIVTTIVVLA RKHLKKWFIK
EEEFPSIIEL SVERGRTRIY NICSFLIEGG
//
