ID A0A2K5VGL6_MACFA Unreviewed; 864 AA.
AC A0A2K5VGL6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Microcephalin {ECO:0000256|ARBA:ARBA00017027};
GN Name=MCPH1 {ECO:0000313|Ensembl:ENSMFAP00000023884.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000023884.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000023884.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000023884.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Implicated in chromosome condensation and DNA damage induced
CC cellular responses. May play a role in neurogenesis and regulation of
CC the size of the cerebral cortex. {ECO:0000256|ARBA:ARBA00025455}.
CC -!- SUBUNIT: Interacts with CDC27 and maybe other components of the APC/C
CC complex. Interacts with histone variant H2AX under DNA damage
CC conditions. {ECO:0000256|ARBA:ARBA00026061}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5VGL6; -.
DR Ensembl; ENSMFAT00000032020.2; ENSMFAP00000023884.2; ENSMFAG00000043546.2.
DR VEuPathDB; HostDB:ENSMFAG00000043546; -.
DR GeneTree; ENSGT00390000018842; -.
DR Proteomes; UP000233100; Chromosome 8.
DR Bgee; ENSMFAG00000043546; Expressed in lung and 13 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0060348; P:bone development; IEA:Ensembl.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0071539; P:protein localization to centrosome; IEA:Ensembl.
DR GO; GO:0046605; P:regulation of centrosome cycle; IEA:Ensembl.
DR GO; GO:0060623; P:regulation of chromosome condensation; IEA:Ensembl.
DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR CDD; cd17716; BRCT_microcephalin_rpt1; 1.
DR CDD; cd17736; BRCT_microcephalin_rpt2; 1.
DR CDD; cd17751; BRCT_microcephalin_rpt3; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 3.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR022047; Microcephalin-like.
DR InterPro; IPR029504; Microcephalin_mammal.
DR PANTHER; PTHR14625; MICROCEPHALIN; 1.
DR PANTHER; PTHR14625:SF3; MICROCEPHALIN; 1.
DR Pfam; PF12258; Microcephalin; 1.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR SMART; SM00292; BRCT; 3.
DR SUPFAM; SSF52113; BRCT domain; 3.
DR PROSITE; PS50172; BRCT; 3.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 1..93
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 679..737
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 780..862
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 346..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 95878 MW; 6E033066832B2B69 CRC64;
MAAPILKDVV AYVEVWSSNG TENYSKTFTT QLVDMGAKVS KTFNKQVTHV IFKDGYQSTW
DKARKRGVKL VSVLWVEKCR TAGAHIDESL FPAANTNEHL PSLIKKKRKC MQPKDFNFKT
PENDKRFQKK FEKMAKELQR QKTSLDDDVP ILLFESNGSL TYSPTIKINS SHHSAMEKRL
QEMKERRENL SPTSSQMIQQ SHDNPSNSLC EAPLNISHDT LCSDESIAGG LHSSFDDLCG
NSECGNQERK LGGSINDTKS DMCISSLVLK TNNTHLSPSF AHLDKSSPQK FLSNLSKEEI
NLQRNIVGKI VTPDQKQAAG MSQETFEEKY RLSPTLSSTK GHLLIHSRPR SSSVKRKRVS
YGFHSPPKEK CKRKRSIRRS IMPRLQLCRS EGSLQCMAGP ALEALGCGES SYDDYFSPDN
LKERNSENLP PKSQLPSNPA QFSCRSLSKK ERTSIFEMSD FSCVGKKPRT VDITSFTAKT
ICSPQKTASG EGCATFSCVT SEESSAPEET LRYCRQAGPQ QKEDAWPEGN GFSYTIEDPA
LPKGHDGDLT PFEGILEEVK EAVGLKSTQD KGTTSKISNS SEGEAPSEHE PRSVVDCNVE
RSAEDKENLP GGYSGSVKNR PTRRDILDGS CDSFKDLIKP HEELKKSGKG KKPTRTLVMT
SMPSEKQNVV IQVVDKLKGF SIAPDVCETT THVLSGKPLR TLNVLLGIAR GCWVLSYDWV
LWSLESGHWI SEEPFELSIH FPAAPYLPKH LQETGSLSEA AELGMTELCR RECHLSAGPY
RGTLFADQPV MFVSPASSPP VAKLCELVHL CGGRVSQVPR QASIVIGPYS GKKKATVKYL
SEKWVLDSIT QHKVCASENY LLPQ
//
