ID A0A2K5VHM2_MACFA Unreviewed; 837 AA.
AC A0A2K5VHM2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Zinc finger protein 546 {ECO:0000313|Ensembl:ENSMFAP00000024237.2};
GN Name=ZNF546 {ECO:0000313|Ensembl:ENSMFAP00000024237.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000024237.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000024237.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000024237.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; A0A2K5VHM2; -.
DR Ensembl; ENSMFAT00000032376.2; ENSMFAP00000024237.2; ENSMFAG00000043709.2.
DR VEuPathDB; HostDB:ENSMFAG00000043709; -.
DR GeneTree; ENSGT00940000163602; -.
DR Proteomes; UP000233100; Chromosome 19.
DR Bgee; ENSMFAG00000043709; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 22.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24399:SF78; C2H2-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24399; ZINC FINGER AND BTB DOMAIN-CONTAINING; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 21.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 22.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 11.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 22.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 22.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 60..131
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 217..244
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 245..272
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 273..300
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 301..328
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 329..356
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 357..384
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 385..412
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 413..440
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 441..468
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 469..496
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 497..524
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 525..552
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 553..580
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 581..608
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 609..636
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 637..664
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 665..692
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 693..720
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 721..748
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 749..776
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 777..804
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 805..832
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 837 AA; 98264 MW; 751C5CDC9ED49CD8 CRC64;
MQVDPPLHGP PNDLLIFQII PLHLLSIMPR LLWILCFSME EAQGKLTSSC RSKTMADVSL
AFRDVSIDLS QEEWECLNPA QRDLYKDVML ENYSNLVSLG YTIPKPDVIT LLEQQKEPWI
VMREGTRSWY TDLEYKYITT NLLSEKNVCK LYLSQLHTGE KSKNTIHEDT IFRNALQCKH
EFERQEGHQM GCVSQMIIQK QISHPLHLKI HAREKSYECK ECRKAFRQQS YLIQHLRIHT
GERPHKCMEC GKAFCRVGDL RVHQTIHAGE RPYECKECGK AFRLHYHLTE HQRIHSGVKP
YECKECGKAF SRVRDLRVHQ TIHAGERPYE CKECGKAFRL HYQLTEHQRI HTGERPYECK
VCGKTFRVQR HISQHQKIHT GVKPYKCNEC GKAFSHGSYL VQHQKIHTGE KPYECKECGK
SFSFHAELAR HHRIHTGEKP YECKECGKAF RLQTELTRHH RTHTGEKPYE CKECGKAFIC
GYQLTLHLRT HTGEIPYECK ECGKTFSSRY NLTQHYRIHT GEKPYICNEC GKAFRLQAEL
TRHHRIHTCE KPYECKECGK AFIHSNQFIS HQRIHTSEST YVCKECGKIF SRRYNLTQHF
KIHTGEKPYI CNECGKAFRF QTELTQHHRI HTGEKPYKCT ECGKAFIRST HLTQHHRIHT
GEKPYECKEC GKTFSRHYHL TQHHRGHTGE KPYICNECGN AFICSYRLTL HQRIHTGEIP
YECKECGKTF SRRYHLTQHF RLHTGEKPYS CKECGNAFRL QAELSRHHIV HTGEKPCKCK
ECGKAFSVNS ELTRHHRIHT GEKPYKCKEC GKAFIRSDQL TLHQRNHVSE EVLLCVM
//
