ID A0A2K5VKY4_MACFA Unreviewed; 1710 AA.
AC A0A2K5VKY4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Rho guanine nucleotide exchange factor 28 {ECO:0000313|Ensembl:ENSMFAP00000025475.2};
GN Name=ARHGEF28 {ECO:0000313|Ensembl:ENSMFAP00000025475.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000025475.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000025475.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000025475.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR Ensembl; ENSMFAT00000033625.2; ENSMFAP00000025475.2; ENSMFAG00000043970.2.
DR VEuPathDB; HostDB:ENSMFAG00000043970; -.
DR GeneTree; ENSGT00940000155831; -.
DR OrthoDB; 2917157at2759; -.
DR Proteomes; UP000233100; Chromosome 6.
DR Bgee; ENSMFAG00000043970; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20876; C1_p190RhoGEF; 1.
DR CDD; cd14680; PH_p190RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037819; ARHGEF28_PH.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR13944; AGAP007712-PA; 1.
DR PANTHER; PTHR13944:SF22; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 658..705
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 853..1048
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1090..1192
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1191..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1315..1344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1645..1710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1501..1528
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 479..498
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1197..1212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1646..1662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1663..1681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1710 AA; 191438 MW; DDADF7AC9C917B65 CRC64;
MQPPRAGPGG GQAGIQWQGG RRGGAGASPA EGAASPARAR GRSSTPKAWL QSCRRQALAS
PGRAFRTPGG GWRGRVPRRP RAGHGAAPRL GSGGCGAIAA DAKAMELSCS EAPLYGQMTV
YAKFDKNVYL PEDAEFYFTY DGSHQRHVMI AERIEDNVLQ SSIPVSSHRE SLLHLAMRWG
LAKLSQFFLC LPGGVQALAL PNEDGATPLD LALRGGHSKL VEDVTNFQGR WSPSFSRVQL
SEEASLHYIH SSETLTLTLN HTAEHLLEAD IKLFRKYFWD RAFLVKAFEQ ETRPEERTAM
PSSGAETEEE VKNSVSSSSA AEKEDVKCVK SLVVQQNEHE DQHSLDLDRS FDVLKKSKPP
STLLAAGRLS DMLNGGDEVY ANCMVIDQVG DLDISYINIE GITATTSPES RGCTLGPQSS
KHTLPTETSP SVYPLSENDE GTVHTEAQRS FMSPSSSCAS NLNLSFGWHG FEKQQSHLKK
RSSSLDALDA DSEGEGHSEP SHICYTPGSQ SSSRTGIPSG DELDSFETNT EPDFNISRAE
SLPLSSNLQS KESLLSGVRS RSYSCSSPKI SLGKTRLVRE LTVCNSSEEQ RAYSLPEPPR
GKRIQEEEWD KYIIPAKSES EKYKVSRTFS FLMNRMTSPR NKSKTKSKDA KDKEKLNRHQ
FAPGTFSGVL QCLVCDKTLL GKESLQCSNC NANVHKGCKD AAPPCTKKFQ EKHNKNKPQT
ILGNSSFRDI PQPGLSLHPS SSMPVGLPTG KRETAGHAHP LSRSVPGTTL ERRSATSLES
ESDSNSCRSR SHSDELLQSM GSSPSTESFI MEDVVDSSLW SDLSSDAQEF EAESWSLVVD
PSFCNRQEKD VIKRQDVIFE LMQTEMHHIQ TLFIMSEIFR KGMKEELQLD HSTVDKIFPC
LDELLEIHRL FFYSMKERRQ ESCAGSDRNF VIDRIGDILV QQFSEENASK MKKIYGEFCS
HHKEAVNLFK ELQQNKKFQN FIKLRNSNLL ARRRGIPECI LLVTQRITKY PVLVERILQY
TKERTEEHKD LCKALCLIKD MIATVDLKVN EYEKNQKWLE ILNKIENKTY TKLKNGHVFR
KQALMSEERT LLYDGLVYWK TATGRFKDIL ALLLTDVLLF LQEKDQKYIF AAVDQKPSVI
SLQKLIAREV ANEERGMFLI SASSAGPEMY EIHTNSKEER NNWMRRIQQA VESCPEEKGG
RTSESDEDKR KAEARVAKIQ QCQEMLTNQD QQICAYLEEK LHIYAELGEL SGFEDVHLEP
HLLIKPDPGE PPQAASLLAA ALKEAESLQV AVKASQMGDV SQSREDSRGD SVLVDTLSSH
DVPGSPTASL VTGGREERGC SDVDPGIQGV VTDLAISDAG EKVECRNFPG SSQSEIIQAI
QNLTRLLYSL QAALTIQDSH IEIHRLVLQQ QEGLSLGHSV LRGGPLQDQK SRDADRQHEE
LANVHQLQHQ LQQEQRRWLR RCDQQQRAQA AKESWLQERE RECQSQEELL LRSRGELDLQ
LQEYQHSLER LREGQRLVER ERARMQAQQS LLSHWKHGRQ RSLPAVFLPG GPEVMELNRS
ESLCHENSFF INEALVQMSF NTFNKPNPSV IHQDATYPTT RSPSDLVRTS ENQVDLKMDP
SQPSNVSHEL WTAAAGSSHQ ILPFHESSKD SCKNDLETSH TESPTPHDSN SHRSQLQAFI
TEGKLNLPAR TMTRQDGETG DGAKENIVYL
//
