ID A0A2K5VML6_MACFA Unreviewed; 521 AA.
AC A0A2K5VML6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=5-hydroxytryptamine receptor 3A {ECO:0000313|Ensembl:ENSMFAP00000025954.2};
GN Name=HTR3A {ECO:0000313|Ensembl:ENSMFAP00000025954.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000025954.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000025954.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000025954.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-
CC selective channel complexes, which when activated cause fast,
CC depolarizing responses in neurons. {ECO:0000256|ARBA:ARBA00037540}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671,
CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=K(+)(in) = K(+)(out); Xref=Rhea:RHEA:29463, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034430};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Na(+)(in) = Na(+)(out); Xref=Rhea:RHEA:34963,
CC ChEBI:CHEBI:29101; Evidence={ECO:0000256|ARBA:ARBA00036239};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
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DR AlphaFoldDB; A0A2K5VML6; -.
DR STRING; 9541.ENSMFAP00000025954; -.
DR Ensembl; ENSMFAT00000034109.2; ENSMFAP00000025954.2; ENSMFAG00000044451.2.
DR VEuPathDB; HostDB:ENSMFAG00000044451; -.
DR GeneTree; ENSGT00940000157705; -.
DR OrthoDB; 5489962at2759; -.
DR Proteomes; UP000233100; Chromosome 14.
DR Bgee; ENSMFAG00000044451; Expressed in temporal lobe.
DR GO; GO:0032154; C:cleavage furrow; IEA:Ensembl.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:InterPro.
DR GO; GO:1904602; C:serotonin-activated cation-selective channel complex; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0099507; F:ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; IEA:Ensembl.
DR GO; GO:0051378; F:serotonin binding; IEA:Ensembl.
DR GO; GO:0022850; F:serotonin-gated monoatomic cation channel activity; IEA:Ensembl.
DR GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:Ensembl.
DR CDD; cd19011; LGIC_ECD_5-HT3A; 1.
DR CDD; cd19063; LGIC_TM_5-HT3; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR008132; 5HT3_rcpt.
DR InterPro; IPR008133; 5HT3_rcpt_A.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF52; 5-HYDROXYTRYPTAMINE RECEPTOR 3A; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 2.
DR PRINTS; PR01709; 5HT3ARECEPTR.
DR PRINTS; PR01708; 5HT3RECEPTOR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Signal {ECO:0000256|RuleBase:RU000687};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687}; Transport {ECO:0000256|RuleBase:RU000687}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT CHAIN 30..521
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT /id="PRO_5030001158"
FT TRANSMEM 254..277
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 289..316
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 336..361
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 495..518
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 47..253
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 260..318
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT DOMAIN 339..511
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 431..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 521 AA; 59819 MW; A84526B382B0C7E5 CRC64;
TRRKLAMLLW VQQALLALLL PTLLAQGEAR RSAGLQGRNT TRPALLRLSD YLLTNYRKGV
RPVRDWRKPT TVSIDVIVYA ILNVDEKNQV LTTYIWYRQY WTDEFLQWNP EDFDNITKLS
IPTDSIWVPD ILINEFVDVG KSPNIPYVYI RHQGEVQNYK PLQVVTACSL DIYNFPFDVQ
NCSLTFTSWL HTIQDINISL WRLPEKVKFD KSVFMNQGEW ELLGVLPDFR EFSMESSHCY
AEMKFYVVIR RRPLFYVVSL LLPSIFLMVM DIVGFYLPPN SGERVSFKIT LLLGYSVFLI
IVSDTLPATA IGTPLIGKVS PGSRAQSGEK PTPYHLLYVS LASALDCTGV YFVVCMALLV
ISLAETIFIV RLVHKQDLQQ PVPAWLRHLV LERIAWLLCL REQSTSQRPP ATSQATKTDD
CSAMRNHCNH MGGPQDLEKN PRGRCSPPPP PREASLAVRG LLQELSSIRH FLEKRDEIRE
VARDWLRVGS VLDKLLFHIY LLAVLAYSIT LVMLWSIWQY A
//
