ID A0A2K5VN88_MACFA Unreviewed; 418 AA.
AC A0A2K5VN88;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Chitinase domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040976};
GN Name=CHID1 {ECO:0000313|Ensembl:ENSMFAP00000026246.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000026246.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000026246.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000026246.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Saccharide- and LPS-binding protein with possible roles in
CC pathogen sensing and endotoxin neutralization. Ligand-binding
CC specificity relates to the length of the oligosaccharides, with
CC preference for chitotetraose (in vitro).
CC {ECO:0000256|ARBA:ARBA00037756}.
CC -!- SUBUNIT: Interacts with STAB1. {ECO:0000256|ARBA:ARBA00038832}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family.
CC {ECO:0000256|ARBA:ARBA00009336}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5VN88; -.
DR STRING; 9541.ENSMFAP00000026246; -.
DR Ensembl; ENSMFAT00000029745.2; ENSMFAP00000026246.2; ENSMFAG00000044543.2.
DR VEuPathDB; HostDB:ENSMFAG00000044543; -.
DR GeneTree; ENSGT00390000012069; -.
DR Proteomes; UP000233100; Chromosome 14.
DR Bgee; ENSMFAG00000044543; Expressed in pituitary gland and 13 other cell types or tissues.
DR GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd02876; GH18_SI-CLP; 1.
DR Gene3D; 3.10.50.10; -; 1.
DR Gene3D; 1.10.8.360; 3,6-anhydro-alpha-l-galactosidase; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR011583; Chitinase_II.
DR InterPro; IPR029070; Chitinase_insertion_sf.
DR InterPro; IPR001223; Glyco_hydro18_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR46066:SF2; CHITINASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46066; CHITINASE DOMAIN-CONTAINING PROTEIN 1 FAMILY MEMBER; 1.
DR Pfam; PF00704; Glyco_hydro_18; 1.
DR SMART; SM00636; Glyco_18; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS51910; GH18_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..418
FT /note="Chitinase domain-containing protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030051651"
FT DOMAIN 104..418
FT /note="GH18"
FT /evidence="ECO:0000259|PROSITE:PS51910"
SQ SEQUENCE 418 AA; 47660 MW; 19A748DB10C1DBC6 CRC64;
MRTLFNILWL ALACSPVHTT LSKSDAKKAA SKTLLEKMKF RSCCPGWSAV ARSWLTATSA
TQSQFSDKPV QDRGLVVTDL KAESVVLEHR SYCSAKARDR HFAGDVLGYV TPWNSHGYDV
TKVFGSKFTQ ISPVWLQLKR RGREMFEVTG LHDVDQGWMR AIRKNAKGLH IVPRLLFEDW
TYDDFRNVLD SEDEIEELSK TVVQVAKNQH FDGFVVEVWN QLLSQKRVGL IHMLTHLAEA
LHQARLLALL VIPPAITPGT DQLGMFTHKE FEQLAPVLDG FSLMTYDYST AHQPGPNAPL
SWVRACVQVL DPKSKWRSKI LLGLNFYGMD YATSKDAREP VVGARYIQTL KDHRPRMVWD
SQASEHFFEY KKSRSGRHVV FYPTLKSLQV RLELARELGV GVSIWELGQG LDYFYDLL
//
