ID A0A2K5VNI6_MACFA Unreviewed; 3465 AA.
AC A0A2K5VNI6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Assembly factor for spindle microtubules {ECO:0000313|Ensembl:ENSMFAP00000026291.2};
GN Name=ASPM {ECO:0000313|Ensembl:ENSMFAP00000026291.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000026291.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000026291.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000026291.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSMFAT00000029692.2; ENSMFAP00000026291.2; ENSMFAG00000044554.2.
DR VEuPathDB; HostDB:ENSMFAG00000044554; -.
DR GeneTree; ENSGT00560000077332; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000044554; Expressed in bone marrow and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072687; C:meiotic spindle; IEA:Ensembl.
DR GO; GO:0036449; C:microtubule minus-end; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0008356; P:asymmetric cell division; IEA:Ensembl.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR GO; GO:0021873; P:forebrain neuroblast division; IEA:Ensembl.
DR GO; GO:0051661; P:maintenance of centrosome location; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0090306; P:meiotic spindle assembly; IEA:Ensembl.
DR GO; GO:0045769; P:negative regulation of asymmetric cell division; IEA:Ensembl.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0048477; P:oogenesis; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0051445; P:regulation of meiotic cell cycle; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0051653; P:spindle localization; IEA:Ensembl.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR CDD; cd21224; CH_ASPM_rpt2; 1.
DR Gene3D; 1.20.5.190; -; 32.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 41.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 66.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 16.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 38.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 909..1045
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1099..1250
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3465 AA; 408739 MW; AD8179AB5D4CB8EB CRC64;
MANRRVGRGC WEVSPTERRP PASSPPVLSL SHFCRSPFLC FGDVLLGDSR TLPLALDNPN
EEVAEVKISH FPAADLGFSV SQRCFVLQPK EKIVISVNWT PFKEGRVREI MTFLVNDVLK
HQAILLGNAE KQKKKKRSLW DTIKKKKISA STSHNRRVSN IQNVNKTFSV SQKVDRVRSP
LQACENLAMN EGGPPTENNS LTLEENKIPI SPISPAFNEC HGATCLPLSV RRSTTYSSLH
ASENRELLNV DSANVSKVSF NEKAVTETSF NSINVNDQSG ENSKLILTPN YSSTLNITQS
QINFLSPDSF VNNSHGANNE LELVTCLSSD MFMTDNSKPV HLQSTTAHEI YQKILSPDSF
IKDNYGLNQD LESESVNPIL SPNQFLKDNM AYMCTSQQTY KVPLSNENSQ VPQSPQDWSK
SEVSPCIPEY QGSKSPKAIF EELVEMKSNY YSFMKQNNPK FSAVQDISSH SHDKQPKRRP
ILSATVTKRK PTCTRENQTE INKPKAKRCL NSAVGEHEKV IHNQKEKEDF HSYLPVIDPV
LSKSKSYKNQ IMPSLTTASV ARKRKSDGSM EDANVRVAVT EHTEEREIKR IHFSPSEPKT
SAVKKTKNVI TPISKCISNR EKLNLKKKTD LLIFKTPISK TSKRTKPIIA VAQSNLTFIK
PLKTDIPRHP MPFAAKNMFY DERWKEKQEQ GFTWWLNFIL TPDDFTVKTN ISEVNAATLL
LGVENQHKIS VPRAPTKEEM SLRAYTARCR LNRLRRAACR LFTSEKMVKA IKKLEIEIEA
RRLIVRKDRH LWKDVGERQK VLNWLLSYNP LWLRIGLETI YGELISLEDN SDVTGLAMFI
LNRLLWNPDI AAEYRHPTVP HLYRDGHEGA LSKFTLKKLL LLICFLDYAK ISKLIDHDPC
LFCKDAEFKA SKEILLAFSR DFLSGEGDLS RHLGLLGLPV NHVQTPFDEF DFAITNLAVD
LQCGVRLVRT MELLTQNWNL SKKLRIPAIS RLQKMHNVDI VLQVLKSRGI ELSDEHGNTI
LSKDIVDRHR EKTLRLLWKI AFAFQVDISL NLDQLKEEIA FLKHTKSIKK TISLLSCHSD
ALINKKKGKR DSGSFEQYSE NIKLLMDWVN AVCAFYNKKV ENFTVSFSDG RVLCYLIHHY
HPCYVPFDAI CQRTTQTVEC TQTGSVVLNS SSESDDSSLD MSLKAFDHEN TSELYKELLE
NEKKNFQLIR SAVRDLGGIP AMINHSDMSN TIPDEKVVIT YLSFLCARLL DLRKEIRAAR
LIQTTWRKYK LKTDLKRHQE RDKAARIIQS AVINFLAKQR LRKRVNAALI IQKYWRRVLA
QRKLLILKKE KLEKVQNKAA SLIQGYWRRY STRKRFLKLK YYSIILQSRI RMIIAVTSYK
RYLWATVTIQ RHWRAYLRRK QDQQRYEMLK SSSLIIQSMF RKWKRRKMQS QVKATVILQR
AFREWHLRKR AKEENSAIVI QSWYRMHKEL RKYIYIRSCV IVIQKRFRCF QAQKLYKRKK
ESILTIQKYY KAYLKGKIER TNYLQKRAAA IQLQAAFRRL KAHNLCRQIR AACVIQSYWR
MRQDRVRFLN LKKTIIKLQA HIRKHQQLQK YKKMKKAAVI IQTHFRAYIF TRKVLASYQK
TRSAVIVLQS AYRGMQARKV YIHILTSVIK IQSYYRAYVS KKEFLSLKNT TIKLQSIVKM
KQTRKQYLHL RAAALFIQQC YRSKKITTQK REEYMQMRES CIKLQAFVRG YLVRKQMRLQ
RKAVISLQSY FRMRKARQYY LKMCKAIIVI QNYYHAYKAQ VNQRKNFLRV KKAATCLQAA
YRGYKVRQLI KQQSIAALKI QSAFRGYNKR VKYQSVLQSI IKIQRWYRAY KTLHDTRTHF
LKTKAAVVSL QSAYRGWKVR KQIRREHQAA LKIQSAFRMA KAQKQFRLFK TAALVIQQNF
RAWTAGRKQR MEYIELRHAV LILQSMWKGK TLRRQLQRQH KCAIIIQSYY RMHVQQKKWK
IMKKAALLIQ KYYKAYSIGR EQHHLYLKTK AAVVTLQSAY RGMKVRKRIK DCNKAAVTIQ
SKYRAYKTKK KYATYRASAI IIQRWYRGIK ITHRQHQEYL NLKKTAIKIQ SVYRGIRVRR
HIQHMHRAAT FIKAMFKMHQ SRISYHTMRK AAIVIQVRFR AYYQGKMHRE KYLTILKAVK
ILQASFRGVR VRWTLRKMQI AATLIQSNYR RYKQQTYFNK LKKITKTIQQ RYRAVKERNI
QFKRYNKLRH SVIYIQAIFR GKKARRHLKM MHVAATLIQR RFRTLMMRRR FLSLKKTAVW
IQRKYRAHLC TKHHLQFLQV QNAVIKIQSS YRRWMIRKKM REMHRAATFI QATFRMHRVH
MRYQALKQVS VVIQQQYRAN RAAKLQRQHY LRQRRSAVIL QAAFRGVKTR RHLKSMHSSA
TLIQSRFRSL LVRRRFISLK KATIFVQRKY RATICAKHKL HQFLQLRKAA ITIQSSYRRL
MVKKKLQEMQ RAAVLIQATF RMHRTCVTFQ TWKQASILIQ QHYRTYRAAK LQKENYIRQW
HSAVVIQTAY KGMKARQHLR EKHKAAIIIQ STYRMYRQYC FYQKLQWATK IIQEKYRANK
KKQKALQHNE LKKETCVQAS FQDMNIQKQI QEQHQAAIII QKHCKAFKIR KHYLHLRATV
VSIQRRYRKL TAVRTQAVIC IQSYYRGFKV RRDIQNMHRA ATLIQSFYRM HRAKVDYQTK
KTAIVVIQNY YRLYVRVKTE RKSFLPVQKS VRTIQAAFRG MKVRQKLKIV SEEKMAAIVN
QSALCCYRSK TQYEAVQSEG VMIQEWYKAS DLACSQEAEY HSQSRAAVTI QNAFRRMVTR
KLETQKCAAL RIQFFLQMAV YRRRFVQQKR AAITLQHYFR TWQTRKQFLL YRKAAVVLQN
HYRAFLSAKH QRQVYLQIRS SVIIIQARSK GFIQKRKFQE IKNSTIKIQA MWRRYRAKKY
LCKVKAACKI QAWYRCWRAH KEYLAILKAV KIIQGCFYTK LERTWFLNVR ASAIIIQRKW
RAILSAKIAH EHFLMIKRHR AACLIQAHYR GYKERQFFLR QKSAALIIQK YIRAREAGKR
ERIKYIEFKK STVILQALVR GWLVRKRILE QKTKIRLLHF TAAAYYHLNA LRIQRAYKLY
LAVKNANKQV NSVICIQRWF RARLQQKKFI QKYSIKKIEH EGQECLSQQN RAASVIQKAV
RHFVLRKKQE KFTSGIIKIQ ALWRGYSWRK KNDCTKIKAI RLSLQVVNRE IREENKLYKR
TALALHYLLT YKHLSAILEA LKHLEVVTRL SPLCCENMAQ SGAISKIFVL IRSCNRSVPC
MEVIRYAVQV LLNVSKYEKT TSAVYDVENC IDTLLELLQI YREKPGNKVA DKGGSIFTKT
CCLLAVLLKT TNRASDVRSR SKVVDRIYSL YKLTAHKHKM NTERILHKQK KNSSISIPFI
PETPVRTRIV SRLKPDWVLR RDNMEEITNP LQAIQMVMDT LGIPY
//
