ID A0A2K5VR62_MACFA Unreviewed; 578 AA.
AC A0A2K5VR62;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Poly(A)-specific ribonuclease PARN {ECO:0000256|ARBA:ARBA00015918};
DE EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
DE AltName: Full=Polyadenylate-specific ribonuclease {ECO:0000256|ARBA:ARBA00031923};
GN Name=PARN {ECO:0000313|Ensembl:ENSMFAP00000027221.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000027221.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000027221.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000027221.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001663};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR AlphaFoldDB; A0A2K5VR62; -.
DR STRING; 9541.ENSMFAP00000027221; -.
DR Ensembl; ENSMFAT00000001405.2; ENSMFAP00000027221.2; ENSMFAG00000044852.2.
DR VEuPathDB; HostDB:ENSMFAG00000044852; -.
DR GeneTree; ENSGT00940000153167; -.
DR Proteomes; UP000233100; Chromosome 20.
DR Bgee; ENSMFAG00000044852; Expressed in lymph node and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0006402; P:mRNA catabolic process; IEA:InterPro.
DR CDD; cd02637; R3H_PARN; 1.
DR CDD; cd12428; RRM_PARN; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034042; PARN_R3H.
DR InterPro; IPR014789; PolyA-riboNase_RNA-binding.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR PANTHER; PTHR15092:SF44; POLY(A)-SPECIFIC RIBONUCLEASE PARN; 1.
DR Pfam; PF04857; CAF1; 1.
DR Pfam; PF08675; RNA_bind; 1.
DR SUPFAM; SSF82708; R3H domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS51061; R3H; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 117..184
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT REGION 499..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 578 AA; 66405 MW; DAEEBD6D39F7396E CRC64;
MDFLLFQFGL CTFKYDYTDS KYITKSFNFY VFPKPFNRSS PDVKFVCQSS SIDFLASQGF
DFNKVFRNGI PYLNQEEERQ LREQYDEKRS QANGAGALSY VSPNTSKCPV TIPEDQKKFI
DQVVEKIEDL LQSEENKNLD LEPCTGFQRK LIYQTLSWKY PKGIHVETLE TEKKERYIVI
SKVDEEERKR REQQKHAKEQ EELNDAVGFS RVIHAIANSG KLVIGHNMLL DVMHTVHQFY
CPLPADLSEF KEMTTCVFPR LLDTKLMAST QPFKDIINNT SLAELEKRLK ETPFSPPKVE
SAEGFPSYDT ASEQLHEAGY DAYITGLCFI SMANYLGSFL SPPKIHVSAR SKLIEPFFNK
LFLMRVMDIP YLNLEGPDLQ PKRDHVLHVT FPKEWKTSDL YQLFSAFGNI QISWIDDTSA
FVSLSQPEQV KIAVNTSKYA ESYRIQTYAE YMGKKQEEKQ IKRKWTEDGW KEADSKRLNP
QCIPYALQNH YYRSNSFTAP STVGKRNLSP SQEEAGLEDG VSGEISDAEL EQTDSCAEPL
SEGRKKAKKL KRMKKELSPA GSISMNSPAT LFEVPDTW
//
