ID A0A2K5VRZ9_MACFA Unreviewed; 683 AA.
AC A0A2K5VRZ9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=TNF receptor associated factor 3 {ECO:0000313|Ensembl:ENSMFAP00000027538.2};
GN Name=TRAF3 {ECO:0000313|Ensembl:ENSMFAP00000027538.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000027538.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000027538.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000027538.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A2K5VRZ9; -.
DR Ensembl; ENSMFAT00000001723.2; ENSMFAP00000027538.2; ENSMFAG00000045167.2.
DR VEuPathDB; HostDB:ENSMFAG00000045167; -.
DR GeneTree; ENSGT00940000160538; -.
DR Proteomes; UP000233100; Chromosome 7.
DR Bgee; ENSMFAG00000045167; Expressed in lymph node and 13 other cell types or tissues.
DR GO; GO:0035631; C:CD40 receptor complex; IEA:Ensembl.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR GO; GO:0031996; F:thioesterase binding; IEA:Ensembl.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR GO; GO:0032481; P:positive regulation of type I interferon production; IEA:Ensembl.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:Ensembl.
DR GO; GO:0032648; P:regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0030162; P:regulation of proteolysis; IEA:Ensembl.
DR GO; GO:0008063; P:Toll signaling pathway; IEA:InterPro.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR CDD; cd03777; MATH_TRAF3; 1.
DR CDD; cd16640; RING-HC_TRAF3; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR049440; TRAF3/5_RING.
DR InterPro; IPR037304; TRAF3_MATH.
DR InterPro; IPR027128; TRAF3_RING-HC.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF76; TNF RECEPTOR-ASSOCIATED FACTOR 3; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF21363; TRAF3_RING; 1.
DR Pfam; PF02176; zf-TRAF; 1.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 3.
DR SUPFAM; SSF57953; Trimerization domain of TRAF; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS50145; ZF_TRAF; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00207}; Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00207};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..683
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030051730"
FT DOMAIN 168..207
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 250..305
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 307..364
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 530..675
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT ZN_FING 250..305
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT ZN_FING 307..364
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT COILED 431..482
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 683 AA; 77506 MW; C78244AB4CF6D541 CRC64;
MLPRPVLISW PQAVLLLWPS LDEKSLTCAA FHVEDGWMIH RDPPSFPQSW GFCVGDFSVS
YFFLTFQRSS KRTKPLVVRQ EGSDHHSSRG ALSSLQLADV PPCFHGAQKE LFFPKMESSK
KMDSPGPLQT NPPLKLHTDR SAGTPIFAPE QGGYKEKFVK TVEDKYKCEK CRLVLCSPKQ
TECGHRFCES CMAALLSSSS PKCTACQESI VKDKVFKDNC CKREILALQI YCRNESRGCA
EQLTLGHLLV HLKNDCHFEE LPCVRADCKE KVLRKDLRDH VEKACKYREA TCSHCKSQVP
MIALQKHEDT DCPCVVVSCP HKCSVQTLLR SELSAHLSEC VNAPSTCSFK RYGCVFQGTN
QQIKAHEASS AVQHVNLLKE WSNSLEKKVS LLQNESVEKN KSIQSLHNQI CSFEIEIERQ
KEMLRNNESK ILHLQRVIDS QAEKLKELDK EIRPFRQNWE EADSMKSSVE SLQNRVTELE
SVDKSAGQVA RNTGLLESQL SRHDQMLSVH DIRLADMDLR FQVLETASYN GVLIWKIRDY
KRRKQEAVMG KTLSLYSQPF YTGYFGYKMC ARVYLNGDGM GKGTHLSLFF VIMRGEYDAL
LPWPFKQKVT LMLMDQGSSR RHLGDAFKPD PNSSSFKKPT GEMNIASGCP VFVAQTVLEN
GTYIKDDTIF IKVIVDTSDL PDP
//
