GenomeNet

Database: UniProt
Entry: A0A2K5VUB9_MACFA
LinkDB: A0A2K5VUB9_MACFA
Original site: A0A2K5VUB9_MACFA 
ID   A0A2K5VUB9_MACFA        Unreviewed;       541 AA.
AC   A0A2K5VUB9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 31.
DE   RecName: Full=TRIM5alpha {ECO:0000256|ARBA:ARBA00032496};
GN   Name=TRIM36 {ECO:0000313|Ensembl:ENSMFAP00000028448.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000028448.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000028448.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000028448.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K5VUB9; -.
DR   Ensembl; ENSMFAT00000002638.2; ENSMFAP00000028448.2; ENSMFAG00000045553.2.
DR   VEuPathDB; HostDB:ENSMFAG00000045553; -.
DR   GeneTree; ENSGT00940000158373; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000233100; Chromosome 6.
DR   Bgee; ENSMFAG00000045553; Expressed in pituitary gland and 13 other cell types or tissues.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   CDD; cd19848; Bbox1_TRIM36_C-I; 1.
DR   CDD; cd19778; Bbox2_TRIM36_C-I; 1.
DR   CDD; cd00063; FN3; 1.
DR   CDD; cd16756; RING-HC_TRIM36_C-I; 1.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 4.10.830.40; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR017903; COS_domain.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR040859; Midline-1_COS.
DR   InterPro; IPR047066; TRIM36_Bbox1_Zfn.
DR   InterPro; IPR047065; TRIM36_Bbox2_Zfn.
DR   InterPro; IPR027726; Trim36_HC-RING.
DR   InterPro; IPR027370; Znf-RING_euk.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR24099:SF18; E3 UBIQUITIN-PROTEIN LIGASE TRIM36; 1.
DR   PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR   Pfam; PF18568; COS; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF00643; zf-B_box; 1.
DR   Pfam; PF13445; zf-RING_UBOX; 1.
DR   SMART; SM00336; BBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS51262; COS; 1.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00024}.
FT   DOMAIN          36..87
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          210..252
FT                   /note="B box-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50119"
FT   DOMAIN          359..416
FT                   /note="COS"
FT                   /evidence="ECO:0000259|PROSITE:PS51262"
FT   DOMAIN          422..513
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
SQ   SEQUENCE   541 AA;  61756 MW;  39B14B3E72E79AA8 CRC64;
     MIYFWDFTEV LNQCTGDGDS NDGFVTIKNI ERELICPACK ELFTHPLILP CQHSICHKCV
     KELLLTLDDS FNDVGSDNSN QSSPRLRLPS PSMDKIDRIN RPGWKRNSLT PRTTVFPCPG
     CEHDVDLGER GINGLFRNFT LETIVERYRQ AARAATAIMC DLCKPPPQES TKSCMDCSAS
     YCNECFKIHH PWGTIKAQHE YVGPTTNFRP KILMCPEHET ERINMYCELC RRPVCHLCKL
     GGNHANHRVT TMSSAYKTLK EKLSKDIDYL IGKESQVKSQ ISELNLLMKE TECNGERAKE
     EAITHFEKLF EILEERKSSV LKAIDSSKKL RLDKFQTQME EYQGLLENNG LVGYAQEVLK
     ETDQSCFVQT AKQLHLRIQK ATESLKSFRP AAQTSFEDYV VNTSKQTELL GELSFFSSGI
     DVPEINEEQS KVYNNALINW HHPEKDKADS YVLEYRKINR EDEMSWNEIE VCGTSKIIQD
     LENSSTYAFR VRAYKGSICS PCSRELILHT PPAPAFALMG SGGIQLEEPI TAKYLEYQED
     M
//
DBGET integrated database retrieval system