ID A0A2K5VW90_MACFA Unreviewed; 731 AA.
AC A0A2K5VW90;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Interferon gamma inducible protein 16 {ECO:0000313|Ensembl:ENSMFAP00000029100.2};
GN Name=IFI16 {ECO:0000313|Ensembl:ENSMFAP00000029100.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000029100.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000029100.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000029100.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5VW90; -.
DR STRING; 9541.ENSMFAP00000029096; -.
DR Ensembl; ENSMFAT00000003293.2; ENSMFAP00000029100.2; ENSMFAG00000041789.2.
DR VEuPathDB; HostDB:ENSMFAG00000041789; -.
DR GeneTree; ENSGT00390000013296; -.
DR OrthoDB; 4893941at2759; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000041789; Expressed in lymph node and 13 other cell types or tissues.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0035458; P:cellular response to interferon-beta; IEA:InterPro.
DR CDD; cd08305; Pyrin; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 4.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR12200:SF5; GAMMA-INTERFERON-INDUCIBLE PROTEIN 16; 1.
DR PANTHER; PTHR12200; INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER; 1.
DR Pfam; PF02760; HIN; 2.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF159141; HIN-2000 domain-like; 4.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50834; HIN_200; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 1..88
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 189..389
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT DOMAIN 506..705
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT REGION 89..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..103
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 731 AA; 82043 MW; 3D8A7863AB57C94F CRC64;
MEKKYKNIVL LKGLEVINDY HFRMVKSLLS KDLKLNVKMR EEYDKIQIAD LMEEKFRGDA
GLGKLIQIFK DIPTLEDLAE TLRKEKLKVK QLAPSRKRKN EVDPASPAPS TSGTVNTEGA
EATPGAQKRK KPTKEKAGTK GSKMSEEQTQ PPCPAGAGLS AAVGHSPPPK TSSSAPPNTS
SAENPKTVAK CPVTPRKNIL QKGPVIVKVL STTKPFEYET PEMEKKTMFH ATVATQTQFF
HVKVLNTNLK EKFNGKKIIV ISDYLEYDSL LEVNEESSVS EAGPNQMFEV PNKIINRAKE
TLKTDILHKQ ASGNIIYGIF MLHKKTVNQK TTIYEIQDDR GKMDVVGTGQ CHNIPCEEGD
KLQLYCFRLR KKNQMSKLIS EMHSFIQVKK KPNPKNNDPK SMKPPQEQSE LPNPSEAGKT
FPESHLQTPQ MPPTTPSSNF FIKKSEDTIT KMNDLMRMQI LKEKSHFPGP FMTSIGTADS
HLHTPQMLPS IPSSSCLTML TPRLKTGPEE VSILDGVQSD LKEVMVLNAT ESFVYEPIEQ
KKMFHATVAT ENEVFRVKVF NIDLKEKFTP KKIIAISNYV CRSGFLEVYP LTVVVDVNAD
RKMEIPQGLI RSANTTPKIS YLCSQTKGSF VNGVFEVHKK NVRGEFTYYE IQDNTGKMEV
VVHGRLTTIN CEEGDKLKLT CFELAPKSGN NGELRSVIHS HIKSSRPGKT RKTYSILIQV
WKLHQAFSSK I
//
