ID A0A2K5VZD9_MACFA Unreviewed; 417 AA.
AC A0A2K5VZD9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Ras association domain family member 5 {ECO:0000313|Ensembl:ENSMFAP00000030191.2};
GN Name=RASSF5 {ECO:0000313|Ensembl:ENSMFAP00000030191.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000030191.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000030191.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000030191.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR AlphaFoldDB; A0A2K5VZD9; -.
DR Ensembl; ENSMFAT00000004396.2; ENSMFAP00000030191.2; ENSMFAG00000042279.2.
DR VEuPathDB; HostDB:ENSMFAG00000042279; -.
DR GeneTree; ENSGT00940000159288; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000042279; Expressed in lymph node and 13 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046651; P:lymphocyte proliferation; IEA:Ensembl.
DR GO; GO:0050672; P:negative regulation of lymphocyte proliferation; IEA:Ensembl.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:1900180; P:regulation of protein localization to nucleus; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20886; C1_RASSF5; 1.
DR CDD; cd17220; RA_RASSF5; 1.
DR CDD; cd21892; SARAH_RASSF5; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR033614; RASSF1-6.
DR InterPro; IPR033623; RASSF5_RA.
DR InterPro; IPR011524; SARAH_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22738:SF9; RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 5; 1.
DR PANTHER; PTHR22738; RASSF; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF16517; Nore1-SARAH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50951; SARAH; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 121..169
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 277..363
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 365..412
FT /note="SARAH"
FT /evidence="ECO:0000259|PROSITE:PS50951"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 384..411
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 26..44
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 46680 MW; 1392AB9C965EBDA0 CRC64;
MAMASSAIGQ RPYPILLDPE PPHYLQSLSG PEPPPPPPTG PRAAVSRRPS PLRPGRTRGA
APGGLPGEPG APTRASRPAR PLRPGLQQRL RRRPGAPRPR DVRSIFEQPQ DPRVPAERGE
GHCFAELVLP GGPGWCDLCG REVLRQALRC ANCKFTCHPE CRSLIRLDCS QQEGSSRDRP
SPESTLTLTF SQNVCKPVEE TQRPPTLQEI KQKIDSYNTR EKNCLGMKLS EDGTYTGFIK
VHLKLRRPVT VPAGIRPQSI YDAIKEVNLA ATTDKRTSFY LPLDAIKQLH ISSTTTVSEV
IQGLLKKFMV VDNPQKFALF KRIHKDGQVL FQKLSIADRP LYLRLLAGPD TEVLSFVLKE
NETGEVEWDA FSIPELQNFL TILEKEEQDK IQQVQKKYDK FRQKLEEALR ESQGKPG
//