ID A0A2K5W065_MACFA Unreviewed; 3808 AA.
AC A0A2K5W065;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Bassoon presynaptic cytomatrix protein {ECO:0000313|Ensembl:ENSMFAP00000030474.2};
GN Name=BSN {ECO:0000313|Ensembl:ENSMFAP00000030474.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000030474.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000030474.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000030474.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Presynaptic active zone
CC {ECO:0000256|ARBA:ARBA00034101}.
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DR Ensembl; ENSMFAT00000004680.2; ENSMFAP00000030474.2; ENSMFAG00000042413.2.
DR VEuPathDB; HostDB:ENSMFAG00000042413; -.
DR GeneTree; ENSGT00620000087961; -.
DR Proteomes; UP000233100; Chromosome 2.
DR Bgee; ENSMFAG00000042413; Expressed in cerebellum and 3 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:Ensembl.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0098683; C:cochlear hair cell ribbon synapse; IEA:Ensembl.
DR GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR GO; GO:0098982; C:GABA-ergic synapse; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0044306; C:neuron projection terminus; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0098831; C:presynaptic active zone cytoplasmic component; IEA:Ensembl.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0098882; F:structural constituent of presynaptic active zone; IEA:Ensembl.
DR GO; GO:0099526; P:presynapse to nucleus signaling pathway; IEA:Ensembl.
DR GO; GO:0035418; P:protein localization to synapse; IEA:Ensembl.
DR GO; GO:0098693; P:regulation of synaptic vesicle cycle; IEA:Ensembl.
DR GO; GO:0097091; P:synaptic vesicle clustering; IEA:Ensembl.
DR CDD; cd15773; FYVE1_BSN; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR030627; Bsn_FYVE_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR008899; Znf_piccolo.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14113; PICCOLO/BASSOON; 1.
DR PANTHER; PTHR14113:SF1; PROTEIN BASSOON; 1.
DR Pfam; PF05715; zf-piccolo; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 99..156
FT /note="Zinc finger piccolo-type"
FT /evidence="ECO:0000259|Pfam:PF05715"
FT DOMAIN 394..451
FT /note="Zinc finger piccolo-type"
FT /evidence="ECO:0000259|Pfam:PF05715"
FT REGION 1..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 456..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1229..1478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1501..1553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1857..1912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2083..2102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2257..2303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2466..2502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2510..2529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2534..2588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2778..2798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2973..3087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3105..3333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3357..3485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3506..3808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2378..2408
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2874..2911
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 18..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..249
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..560
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..639
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..697
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 702..716
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..749
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..783
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..910
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..955
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1038..1052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1237..1265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1391..1422
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1458..1478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1501..1532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1533..1550
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2288..2303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2481..2501
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2978..3011
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3016..3035
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3047..3067
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3105..3123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3135..3161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3219..3239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3391..3411
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3509..3534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3546..3574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3588..3615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3635..3649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3672..3745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3753..3779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3808 AA; 407312 MW; F46C5E92C25A30DA CRC64;
MTSAGTSRRL DPKESLGSQR AASPTPKQAS ATTPGQESPR ETRAQGPAGQ EADGPRRTLQ
VDSRTQRSGR SPSVSPDRGS TPTSPYSVPQ IAPLPSSTLC PICKTSDLTS TPSQPNFNTC
TQCHNKVCNQ CGFNPNPHLT QVKEWLCLNC QMQRALGMDM TTAPRSKSQQ QLHSPALSPA
HSPAKQPLGK PEQERSRGPG GLQPGSHQGE MARATSVPEP AQAAAPPEVG RVSPQPPQPT
KPSTAEPRPP AGEAPAKSAT AVPTGLGATE QTQEGLTGKL FGLGASLLTQ ASTLMSVQPE
ADTQGQPAPS KGSPKIVFSD ASKEAGPKPL GLGPGPGPAP GAKTEPGART GPGSGPGALP
KTGGTTSPKH GRAEHQAASK AAAKPKTMPK ERATCPLCQA ELNVGSKSPA NYNTCTTCRL
QVCNLCGFNP TPHLVEKTEW LCLNCQTKRL LEGSLGEPTP VLPPTSQQPP VGAPHRASGA
SPLKQKGSQG LGQPSGPLPA KASPLPTKAS PLPTKASPQA KPLRASEPSK TPSSAQEKKT
GVPTKAEPMP KPPPETTPTP GTPKVKSGVR RAEPATPVVK AVPEAPKGGE AEDLVGKPYS
QDMSRSPQSL SDTGYSSDGI SSSQSEITGV VQQEVEQLDS AGVTGPHPPS PSEIHKVGSS
MRPLLQAQGL APSGERSKPL SSSTGEEQKQ RPHSLSITPE AFDSDEELED ILEEDEDSVE
WRRRREKQDT AESSDDFGSQ LRHDYVEDSS EGGLSPLPPQ PPARAAELTD EEFMRRQILE
MSAEEDNLEE DDTATSGRGL AKHGTQKGGP RPRPEPSQEP AALPKRRLPH NATTGYEELL
PEGGPAEATD GSGALQGGLR RFKTIELNST GSYSHELDLG QGPDPSLDRE PELEMESLTG
SPEDRSRGEH SSTLPASTPS YTSGTSPTSL SSLEEDSDSS PSRRQRLEEA KQQRKARHRS
HGPLLPTIED SSEEEELREE EELLREQEKM REVEQQRIRS TARKTRRDKE ELRAQRRRER
SKTPPSNLSP IEDASPTEEL RQAAEMEELH RSSCSEYSPS PSLDSEAEAL DGGPSRLYKS
GSEYNLPTFM SLYSPTETPS GSSTTPSSGR PLKSAEEAYE EMMRKAELLQ RQQGQAAGAR
GPHGGPSQPT SPRGLGSFEY QDTADRDYGR AAQPVAEGTP ASLGAAMYEE ILQTSQSIVR
MRQASSRDLA FAEDKKKEKQ FLNAESAYMD PMKQNGGPLT PGTSPTQLTA PVSFSTPTSS
DSSGGRVIPD VRVTQHFAKE TQDPLKLHSS PASPSLTSKE VGMPFSQGPG TPATTAVAPC
PAGLPRGYMT PASPSGSERS PSPSSTAHSY GHSPTTANYG SQTEDLPQAP IGLAAAGQAA
REKPLSASDG EGGTPQPSRA YSYVASSSPP LSPSSPSESP TFSPGKLGPR ATAEFSTQTP
SPAPASDMPR SPGAPTPSPM VAQGTQTPHR PSTPRLVWQE SSQEAPFMVI TLASDASSQT
RMVHASASTS PLCSPTEIQP TTHGYSQTTP PSVSQLPPEP PGPPGFPRAP SAGADGPLAL
YGWGALPAEN ISLCRISSVP GTSRVEPGPR PPGTAVVDLR TAVKPTPIIL TDQGMDLTSL
AVEARKYGLA LDPIPGRQST AVQPLVINLN AQEQTHTFLA TATTVSITMA SSVLMAQQKQ
PVVYGDPYQS RLDFGQGGGS PVCLAQVKQV EQAVQTAPYR SGPRGRPREA KFARYNLPNQ
VAPLARRDVL ITQMGTAQSI GLKPGPVPEL GAEPHRATPA ELRSHALPGA RKPHTVVVQM
GEGTAGTVTT LLPEEPAGAL DLTGMRPESQ LACCDMVYKL PFGSSCTGTF HPAPSVPEKS
MADAAPPGQS SGPFYGPRDP EPPEPPTYRA QGAVGPGPHE EQRPYPQGLP GRLYSSMSDT
NLAEAGLNYH AQRIGQLFQG PGRESAMDLS SLKHSYSLGF ADGRYLGQGL QYGSVTDLRH
PTDLLAHPLP MRRYSSVSNI YSDHRYGPRG EAIGFQEASL AQYSATTARE ISRMCAALNS
MDQYGGRHGI GGGGPDLVQY QPQHGPGLSA PQSLAPLRPG LLGNPTFPEG HPSPGNFAQY
GPAAGQGTAV RQLLPSTATV RAADGMIYST INTPIAATLP ITTQPASVLR PMVRGGMYRP
YASGGITAVP LTSLTRVPMI APRVPLGPTG LYRYPAPSRF PIASSVPPAE GPVYLGKPAA
AKASGAGGPP RPEIPVGAVR EEPLPTTTPA AIKEAAGAPA PAPLAGRKPP VDAAPGGGSG
ALSRSGLEKE EASQEERQRK QQEQLLQLER ERVELEKLRQ LRLQEELERE RVELQRHREE
EQLLVQRELQ ELQTIKHHVL QQQQEERQAQ FALQREQLAQ QRLQLEQIQQ LQQQLQQQLE
EQKQRQKAPF PAACEAPGRG PPLAAAELAQ NGQYWPPLTH AAFIAMAGPE GPGQPREPVL
HRGLPSSASD MSLQTEEQWE ASRGGIKKRH SMPRLRDACE PESVAEPCMV RRITDSSVQT
DDEDGEGRYL LSRRRRARRS ADCSVQTDDE DSAEWEQPVR RRRSRLPRHS DSGSDSKHDA
TASSSSAAAT VRAMSSVGIQ TISDCSVQTE PDQLPRVSPA IHITAATDPK VEIIRYISAP
EKTGRGESLA CQTEPDGQAQ GVAGPQLVGP TAISPYLPGI QIVTPGPLGR FEKKKPDPLE
IGYQAHLPPE SLSQLVSRQP PKSPQVLYSP VSPLSPHRLL DTSFASSERL NKAHVSPQKH
FTADSALRQQ TLPRPMKTLQ RSLSDPKPLS PTAEESAKER FSLYQHQGGL GSQVSALPPN
SLVRKVKRTL PSPPPEEAHL PLAGQASPQL YAASLLQRGL TGPTSVPATK ASLLRELDRD
LRLVEHESTK LRKKQAELDE EEKEIDAKLK YLELGITQRK ESLAKDRGGR DYPPLRGLGE
HRDYLSDSEL NQLRLQGCTT PAGQYVDFPA TATAPAAPSG PTAFQQPRFQ PPTPQYSAGS
GEPTQNGFPA HQAPTYPGPN TYPAPAFPPG TSYPAEPGLP NQQAFHPTGH YAGQTPMPTT
QSTLFPVPAD SRAPLQKPHQ TSLADLEQKV PTNYEVIASP VVAMSSAPSE TSYSGSAVSS
SYEQGKVPEV PRASERGSAS QSPAPTYPSD SHYTSLEQNV PRNYVMIDDI SELTKDSTST
APDSQRLEPL GPGSSGRPGK ELGEPGVLEG PTLPCCYARG EEESEEDSYD PRGKGGHLRS
MESNGRPASS HYYGDSDYRH GARVEKYGPG PMGPKHPSKS LAPAAISSKR SKHRKQGMEQ
KISKFSPIEE AKDVESDLAS YPPPAVSSSL VSRGRKFQDE ITYGLKKNVY EQQRYYGMST
RDTVEEDDRI YGGSSRSRAP SAYSGEKLSS HDFSGRGKGY EREREAVERL QKAGPKPSSL
SMAHSRARPP MRSQASEEES PVSPLGRPRP AGGPLPPSGD TCPQFCSSHS MPDVQEHVKD
GPRAHAYKRE EGYILDDSHC VVSDSEAYHL GQEETDWFDK PRDARSDRFR HHGGHAVSSS
SQKRGPARHS YHDYDEPPEE GLWPHDEGGP GRHASAKEHR HHGDHGRHSG RHTGEEPGRR
AAKPHARDLG RHEARPHSQP SSAPAMPKKG QPGYPSSAEY SQPSRAPSAY HHASDSKKGS
RQAHSGPAAL QSKAEPQAQP QLQGRQAAPG PQQSQSPSSR QMPSGAASRQ PQPQQQQQQQ
QGLGLQPPQQ APARLGCSNR ASQPPGAQPL LPASLQGSLS QAPPQPQALN QQDRHGQNRQ
MALKGQPKHH NRGGLLRPSQ RQDLDLQV
//
