ID A0A2K5W3T3_MACFA Unreviewed; 222 AA.
AC A0A2K5W3T3; A0A2K5W3X1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=ascorbate ferrireductase (transmembrane) {ECO:0000256|ARBA:ARBA00024225};
DE EC=7.2.1.3 {ECO:0000256|ARBA:ARBA00024225};
GN Name=CYB561D2 {ECO:0000313|Ensembl:ENSMFAP00000031741.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000031741.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000031741.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000031741.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
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DR RefSeq; XP_005547267.1; XM_005547210.2.
DR RefSeq; XP_015301432.1; XM_015445946.1.
DR AlphaFoldDB; A0A2K5W3T3; -.
DR SMR; A0A2K5W3T3; -.
DR Ensembl; ENSMFAT00000005961.2; ENSMFAP00000031741.2; ENSMFAG00000036934.2.
DR GeneID; 102142038; -.
DR KEGG; mcf:102142038; -.
DR VEuPathDB; HostDB:ENSMFAG00000036934; -.
DR GeneTree; ENSGT00440000038072; -.
DR OMA; TSWFSWH; -.
DR Proteomes; UP000233100; Chromosome 2.
DR Bgee; ENSMFAG00000036934; Expressed in colon and 12 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR GO; GO:0020037; F:heme binding; IEA:Ensembl.
DR GO; GO:0140571; F:transmembrane ascorbate ferrireductase activity; IEA:Ensembl.
DR GO; GO:0140575; F:transmembrane monodehydroascorbate reductase activity; IEA:Ensembl.
DR GO; GO:0140576; P:ascorbate homeostasis; IEA:Ensembl.
DR CDD; cd08761; Cyt_b561_CYB561D2_like; 1.
DR Gene3D; 1.20.120.1770; -; 1.
DR InterPro; IPR045150; CYB561D1/2.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR PANTHER; PTHR15422; OS05G0565100 PROTEIN; 1.
DR PANTHER; PTHR15422:SF21; TRANSMEMBRANE REDUCTASE CYB561D2; 1.
DR Pfam; PF03188; Cytochrom_B561; 1.
DR SMART; SM00665; B561; 1.
DR PROSITE; PS50939; CYTOCHROME_B561; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ SEQUENCE 222 AA; 23965 MW; 5858F0A532F9E8F5 CRC64;
MALSAETESH IYRALRTASG AAAHLVALGF TIFVAVLARP GSSLFSWHPV LMSLAFSFLM
TEALLVFSPE SSLLRSLSRK GRARCHWVLQ LLALLCALLG LGLVILHKEQ LGKAHLATRH
GQAGLLAVLW AGLQCSGGVG LLYPKLLPRW PLAKLKLYHA TSGLVGYLLG SASLLLGMCS
LWFTASVTGA VWYLAALCPV LTSLVIMNQV SNAYLYRKRI QP
//
