ID   A0A2K5W3U6_MACFA        Unreviewed;       613 AA.
AC   A0A2K5W3U6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Scm polycomb group protein homolog 1 {ECO:0000313|Ensembl:ENSMFAP00000031707.2};
GN   Name=SCMH1 {ECO:0000313|Ensembl:ENSMFAP00000031707.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000031707.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000031707.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000031707.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the SCM family. {ECO:0000256|ARBA:ARBA00008469}.
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DR   RefSeq; XP_015307111.1; XM_015451625.1.
DR   AlphaFoldDB; A0A2K5W3U6; -.
DR   Ensembl; ENSMFAT00000005927.2; ENSMFAP00000031707.2; ENSMFAG00000036779.2.
DR   GeneID; 101925446; -.
DR   CTD; 22955; -.
DR   VEuPathDB; HostDB:ENSMFAG00000036779; -.
DR   GeneTree; ENSGT00940000157999; -.
DR   OrthoDB; 2908161at2759; -.
DR   Proteomes; UP000233100; Chromosome 1.
DR   Bgee; ENSMFAG00000036779; Expressed in adult mammalian kidney and 13 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd20108; MBT_SCMH1_rpt2; 1.
DR   CDD; cd09578; SAM_Scm; 1.
DR   Gene3D; 2.30.30.140; -; 2.
DR   Gene3D; 3.90.1150.190; SLED domain; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR004092; Mbt.
DR   InterPro; IPR047280; MBT_SCMH1_rpt2.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR047531; SAM_Scm-like.
DR   InterPro; IPR033763; SCML2_RBR.
DR   InterPro; IPR021987; SLED.
DR   InterPro; IPR038348; SLED_sf.
DR   PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR   PANTHER; PTHR12247:SF68; POLYCOMB PROTEIN SCMH1; 1.
DR   Pfam; PF02820; MBT; 2.
DR   Pfam; PF17208; RBR; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   Pfam; PF12140; SLED; 1.
DR   SMART; SM00561; MBT; 2.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF63748; Tudor/PWWP/MBT; 2.
DR   PROSITE; PS51079; MBT; 2.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT   REPEAT          1..79
FT                   /note="MBT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT   REPEAT          87..188
FT                   /note="MBT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT   DOMAIN          546..611
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   REGION          186..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   613 AA;  68072 MW;  682A6D6CB0F967E7 CRC64;
     MQSYTPPSNE FKISMKLEAQ DPRNTTSTCI ATVVGLTGAR LRLRLDGSDN KNDFWRLVDS
     AEIQPVGNCE KNGGMLQPPL GFRLNASSWP MFLLKTLNGA EMAPIRIFHK EPPSPSHNFF
     KMGMKLEAVD RKNPHFICPA TIGEVRGSEV LVTFDGWRGA FDYWCRFDSR DIFPVGWCSL
     TGDNLQPPGT KVVIPKNPYP ASDVNTEKPS IHSSTKTVLE HQPGQRGRKP GKKRGRTPKT
     LISHPISAPS KTAEPLKFPK KRGPKPGSKR KPRTLLNPPP ASPTTSTPEP DTSTVPQDAA
     TIPSSAMQAP TVCIYLNKNG STGPHLDKKK VQQLPDHFGP ARASVVLQQA VQACIDCAYH
     QKTVFSFLKQ GHGGEVISAV FDREQHTLNL PAVNSITYVL RFLEKLCHNL RSDNLFGNQP
     FIQTHLSLTA TEYSHSHDRY LPGETFVLGN SLARSLEPHS DSMDSASNPT NFVSTSQRHR
     PLLPSCGLPP STASAVRRLC SRGVLKGSNE RRDMESFWKL NRSPGSDRYL ESRDASRLSG
     RDPSSWTVED VMQFVQEADP QLGPHADLFR KHEIDGKALL LLRSDMMMKY MGLKLGPALK
     LSYHIDRLKQ GKF
//