ID A0A2K5W4I4_MACFA Unreviewed; 1168 AA.
AC A0A2K5W4I4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Potassium voltage-gated channel subfamily Q member 2 {ECO:0000313|Ensembl:ENSMFAP00000031996.2};
GN Name=KCNQ2 {ECO:0000313|Ensembl:ENSMFAP00000031996.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000031996.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000031996.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000031996.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A2K5W4I4; -.
DR Ensembl; ENSMFAT00000006217.2; ENSMFAP00000031996.2; ENSMFAG00000042590.2.
DR VEuPathDB; HostDB:ENSMFAG00000042590; -.
DR GeneTree; ENSGT00940000160093; -.
DR Proteomes; UP000233100; Chromosome 10.
DR Bgee; ENSMFAG00000042590; Expressed in temporal lobe and 3 other cell types or tissues.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735:SF4; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF16642; KCNQ2_u3; 1.
DR Pfam; PF03520; KCNQ_channel; 2.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 366..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 472..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..556
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 368..560
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 704..851
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT DOMAIN 861..923
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 43..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 677..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..893
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..138
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..189
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..885
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1168 AA; 125348 MW; 39296CA3BEC123BA CRC64;
MHPPLLPTLP LCPGAAQSLG GGCDPLCSYL GPSLSSALLC TPQLRQGRPP TGSDRVPQFR
QGPSVQTGPP AQTGPPAQTG PTQLRQGPQL RQGPPAQTGP PAQTGPPSAD RPPAQTGPPA
QTGPPAQTGP PSADRPSPVQ TGPPSADRAP SSDRAPQCRQ GPQLRQGPPA QTGPPPFRQG
PPAQTGPPSS DRPPRSDRVP QCRQGLPAQT GPPAQTGPPS ADRASQLRQG PPAQTGPPSS
DRPSPVQTGC PSSDRAPQLR QAPPVQTGSP SSDRAPQRRQ GGGEGGPMVF VLSCVPGCTV
SRGLNLAAQR LGRDGGPVWV SPSLQFPLGA SCPAAWSLGQ NCPCGGPGWA PRASPVSRGG
LSFPPLQEIV TIVVFGVEYF VRIWAAGCCC RYRGWRGRLK FARKPFCVID IMVLIASIAV
LAAGSQGNVF ATSALRSLRF LQILRMIRMD RRGGTWKLLG SVVYAHSKEL VTAWYIGFLC
LILASFLVYL AEKGENDHFD TYADALWWGL ITLTTIGYGD KYPQTWNGRL LAATFTLIGV
SFFALPAGIL GSGFALKVQE QHRQKHFEKR RNPAAGLIQS AWRFYATNLS RTDLHSTWQY
YERTVTVPMY SSQTQTYGAS RLIPPLNQLE LLRNLKSKSG LAFRKEPPPE PSPSKGSPCR
GPLCGCCPGR SSQKVSLKDR VFSSPRGVAA KGKGSPQAQT VRRSPSADQS LEDSPSKVPK
SWSFGDRSRA RQAFRIKGAA SRQNSEEASL PGEDIVDDKS CPCEFVTEDL TPGLKVSIRA
VCVMRFLVSK RKFKESLRPY DVMDVIEQYS AGHLDMLSRI KSLQSRIDMI VGPPPPSTPR
HKKYPTKGPT APPRESPQYS PRVDQIVGRG PAITDKDRTK GPAEAELPED PSMMGRLGKV
EKQVLSMEKK LDFLVNIYMQ RMGIPPTETE AYFGAKEPEP APPYHSPEDS REHVDRHGCI
VKIVRSSSST GQKNFSAPPA APPVQCPPST SWQPQSHPRQ GHGTSPCGGP WLPGAHPAAT
CPRSGHCLPR RGQPRQHRVP EAGGRPGLQA PRGDSAGQRH VHLHPVRGPR GAGAFLQRLQ
HLPVQGEPGC SQQLLRGRGA LCQSQALHRG GRVRHRLRPL YPLRAPATLA PHAIAVCHPL
AVPVAAASPF APLPLAVCTF VHAPKNIS
//
