ID A0A2K5W4I8_MACFA Unreviewed; 1378 AA.
AC A0A2K5W4I8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Adhesion G protein-coupled receptor F5 {ECO:0000313|Ensembl:ENSMFAP00000032002.2};
GN Name=ADGRF5 {ECO:0000313|Ensembl:ENSMFAP00000032002.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000032002.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000032002.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000032002.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR STRING; 9541.ENSMFAP00000032002; -.
DR Ensembl; ENSMFAT00000006223.2; ENSMFAP00000032002.2; ENSMFAG00000037042.2.
DR VEuPathDB; HostDB:ENSMFAG00000037042; -.
DR GeneTree; ENSGT00940000154603; -.
DR OrthoDB; 3876300at2759; -.
DR Proteomes; UP000233100; Chromosome 4.
DR Bgee; ENSMFAG00000037042; Expressed in lung and 13 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15254; 7tmB2_GPR116_Ig-Hepta; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR45813:SF4; ADHESION G PROTEIN-COUPLED RECEPTOR F5; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1378
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030051948"
FT TRANSMEM 1044..1070
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1091..1112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1132..1154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1166..1188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1208..1231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1251..1271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1283..1308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 163..270
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 271..349
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 508..598
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1049..1307
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 1378 AA; 153136 MW; F8B47173E86BF62B CRC64;
MKSPKRTTLC LMFIVIYSSK ATLNWNLEST IHPLSLHEYE PAGEEALRQK RAVATKSPTA
EEYTVNIEIS FENASFLDPI KAYLNSLSFP IHGNNTDQIL SINVTTVCRP AGNEIWCSCE
TGYGWPRERC LHSLTCQEHD IFLPGHHCSC LKELPTKGPF CLLQEDVTLN MRVRLNVGFQ
EDLMNTSSAL YRSYKTDLET AFRKGYGILP GFKGVTVTGF KSGSVVVTYE VKTTAPSLEL
IHKANEQVVQ SLNQTYKMDY NSFQALTSNE TKFSVTPEII FEGDTVSLVC ENELLSSNVS
WRYEEQQLEI QNSSKFSIYT AVFNNMTSVS KLTIRNITPG DAGEYVCKLI LDIFEYEGKK
KIDVMPIQIL ANEEMKVMCD NNPVSLNCCS QSNVNWSKVE WKQEGKISIP GTPETDIDSS
CSRYTLKADG TQCPSGSSGT TVVYTCEFIS AYGARGSANI KVTFISVGDN SSHKSEVHEV
LRHVMEMSTV QSTTRNSLET SKAQEQQANL TMTPDTISVS EGQNFSIKCI SDVSNYDEVY
WNTSAGIKIY QRFYTTRRYP DGAESVLTVK TSTREWNGTY HCIFRYKNSY SIATKDVVVH
PLPLELNIMV DPLEATVLCS GSHHIKCCIE EDGDYKVTFH MGSLSLPAEK EVNKQQVCYK
HNFSANSVSW CSKTVDVYCH FTNAANNSVW SPSMKLNLVP GENITCQDPI IGVGEPGKVI
QKLCRFSNIP SSPDSPVGGI ITYKCVGSQW EEKRNDCIFA PVNSLLQMAK ALIKSPSQDE
KLPTYLKDLS ISIDKVEHEI SSSPGSLGAI INILDLLSTV PTEVNSETMM HVLSTVNVIL
GKPVLNTWKV LQQRRTNQSS QLLHSVERFS QALQSGDSPP LSFFRTNVQM SSMVIKSSHP
KTYQQRFVFP HFDLWGNVVI DKSYLEKLQS DSSVVTMAFP TLQAILAQDI QENNFAGSLV
MTTTVNHNIT MPFRISMTFK NNSPSGGKTQ CVFWNFRLAD NTGGWDSNGC YVEEGDGDNV
TCICDHLTSF SILMSPDSPD PRSLLGILLD IISYVGVGFS ILSLAACLIV EAVVWKSVTK
NRTSYMRHTC IVNIAASLLI ANTWFIVVAA IQGNHYILCK TACVAATFFI HFFYLSVFFW
MLTLGLMLFY RLVFILHETS RSTQKAIAFC LGYGCPLAIS VITLGATQPR EVYTRKNVCW
LNWEDTKALL AFAIPALIIV VVNITITIVV ITKILRPSIG DKPCKQEKSS LFQISKSIGV
LTPLLGLTWG FGLTTVFPGT NLVFHIIFAV LNVFQGLFIL LFGCLWDLKV QEALLNKFSL
SRWSSQHSKS TSLGSSTPVF SMSSPISRRF NNLFGKTAAS KIPPGHDGNL VSSGSSAI
//
