ID A0A2K5W6U7_MACFA Unreviewed; 1100 AA.
AC A0A2K5W6U7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=ADAMTS like 4 {ECO:0000313|Ensembl:ENSMFAP00000032769.2};
GN Name=ADAMTSL4 {ECO:0000313|Ensembl:ENSMFAP00000032769.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000032769.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000032769.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000032769.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5W6U7; -.
DR STRING; 9541.ENSMFAP00000032769; -.
DR Ensembl; ENSMFAT00000006993.2; ENSMFAP00000032769.2; ENSMFAG00000002869.2.
DR VEuPathDB; HostDB:ENSMFAG00000002869; -.
DR GeneTree; ENSGT00940000161136; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000002869; Expressed in heart and 9 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005614; C:interstitial matrix; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0002064; P:epithelial cell development; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0070285; P:pigment cell development; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR PANTHER; PTHR13723:SF281; NO LONG NERVE CORD, ISOFORM C; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 5.
DR Pfam; PF00090; TSP_1; 1.
DR SMART; SM00209; TSP1; 6.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1100
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030051989"
FT DOMAIN 1055..1092
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 78..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..97
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1100 AA; 119282 MW; 2CCB69FA1E9C428A CRC64;
MENWAGRPWL YLLLLLLLSL PQLCLDQEVL SGHSLQTPTE EGQGLEGVWG PWVQWASCSQ
PCGVGVQRRS RTCQLPTVQL RPSLPLPPRP PRHPEALLPR GQGPRPQTSP ETLPLYRTQS
RGRGGPLRGP ASHLGREETQ EIQAARRSRL RDPIKPGMFG YGRVPFALPL HRNRRHPRRP
PRSELSLISS RGEEPIPSPT PRAEPFSTNG SPKTELPPTE LSVHTPSPQA EPLSPETAQT
EVAPRTRPAP PQHHPRAQAA DTEAPSPTRS LGEGGFFRAS PQPRRPSSQG WASPQVAGRR
PDPFPSVPRG RGQQGQGPWG MGGTPHGHRL EPDPQHPDGW LPLLSNGPHA SSLWSLFAPS
SPIPRCSGES EQLRACSQAP CPPEQPDPRA LQCAAFNSQE FMGQLYQWEP FTEAPLLPLR
RAFFLLPGAG SGDSTGGVQG SQRCELNCRP RGFRFYVRHT EKVQDGTLCQ PGAPDICVAG
RCLSPGCDGI LGSGRRPDGC GVCGGDDSTC RLVSGNLTDR GGPLGYQKIL WIPAGASRLQ
IAQLRPSSNY LALRGPGGRS IINGNWAVDP PGSYRAGGTV FRYNRPPREE GKGESLSAEG
PTTQPVDVYM IFQEENPGVF YQYVISSSPP ILENPTSEPA VPQLQPEILR VEPPLAVVPR
PARTPGTLQR QVRIPQMPAP PHPRTPLGSP AAYWKRVGHS ACSASCGKGV WRPIFLCISR
ESGEELDERS CAAGARPPAS PEPCHGAPCP PYWEAGEWTS CSRSCGPGTQ HRQLQCRQEF
GGGGSSVPPE RCGHLPRPNI TQSCQLRLCG HWEVGSPWSQ CSVRCGRGQR SRQVRCVGNN
GDEVSEQECA SGPPQPPSRE ACDMGPCTTA WFHSDWNSKC SAECGTGIQR RSVVCLGSGA
ALGPGQGEAG AGTGQSCPPG SRPPDMRACS LGPCERTWRW YTGPWGECSS ECGSGTQRRD
IICVSKLGME FNVTSPSNCS HLPRPPALQP CQGQACQDRW FSTPWSPCSR SCQGGTQTRE
VQCLSANQTL STRCPPQLRP SRKRPCNSQP CSQRPDDQCK DSSPHCPLVV QARLCVYPYY
TATCCRSCAH VLERSPQDPS
//
