ID A0A2K5W735_MACFA Unreviewed; 482 AA.
AC A0A2K5W735;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Histone-lysine N-methyltransferase PRDM7 {ECO:0008006|Google:ProtNLM};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000032917.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000032917.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000032917.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; A0A2K5W735; -.
DR SMR; A0A2K5W735; -.
DR STRING; 9541.ENSMFAP00000032917; -.
DR Ensembl; ENSMFAT00000007141.2; ENSMFAP00000032917.2; ENSMFAG00000003001.2.
DR VEuPathDB; HostDB:ENSMFAG00000003001; -.
DR GeneTree; ENSGT00940000158211; -.
DR Proteomes; UP000233100; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR CDD; cd19193; PR-SET_PRDM7_9; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR003655; aKRAB.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR044417; PRDM7_9_PR-SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019041; SSXRD_motif.
DR PANTHER; PTHR14112:SF1; KRAB-RELATED DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR14112; SYNOVIAL SARCOMA, X MEMBER; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF09514; SSXRD; 1.
DR SMART; SM00349; KRAB; 1.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS50806; KRAB_RELATED; 1.
DR PROSITE; PS50280; SET; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 36..99
FT /note="KRAB-related"
FT /evidence="ECO:0000259|PROSITE:PS50806"
FT DOMAIN 39..109
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 257..371
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 157..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 482 AA; 55332 MW; 56853BDF7EDA1435 CRC64;
MGHNLEKEGR SLCLTETPRG PRLCPIHRVE EKDQLDVKDA FKDISIYFTK EEWAEMGDWE
KTRYRNVKRN YNALITIGLR ATRPAFMCHR RQAIKLQVDD TEDSDEEWTP RQQVKPPWMA
VRVEQSKHQK GMPKASFNNE SSLKEVSGMA NLLNTSGSEQ AQKPVSPPGE ARTSGQHSRL
KLELRRKETE GKMYSLRERK GHAYKEVSEP QDDDYLYCEM CQNFFIDSCA AHGPPTFIKD
SAVEKGHPNR SALSLPPGLR IGPSGIPQAG LGVWNEASDL PLGLHFGPYE GRITQDEEAA
NNGYSWLITK GRNCYEYVDG KDKSWANWMR YVNCARDDEE QNLVAFQYHR QIFYRTCRVI
RPGCELLVWY GDEYGQELGI KWESLHCLNK TSTLTKNFLF QNQSQRSIHV PHAVWPFQVR
NFSVTTWNAI TPLRTSEDHL QEDSSNQRIS AQGIRIRSSN ILIHAAVMTK PKVKRSKKGP
NS
//
