ID   A0A2K5WBY1_MACFA        Unreviewed;       963 AA.
AC   A0A2K5WBY1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=NLR family pyrin domain containing 7 {ECO:0000313|Ensembl:ENSMFAP00000034557.2};
GN   Name=NLRP7 {ECO:0000313|Ensembl:ENSMFAP00000034557.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000034557.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000034557.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000034557.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NLRP family.
CC       {ECO:0000256|ARBA:ARBA00008665}.
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DR   AlphaFoldDB; A0A2K5WBY1; -.
DR   Ensembl; ENSMFAT00000008787.2; ENSMFAP00000034557.2; ENSMFAG00000003765.2.
DR   VEuPathDB; HostDB:ENSMFAG00000003765; -.
DR   GeneTree; ENSGT00940000164627; -.
DR   OrthoDB; 55870at2759; -.
DR   Proteomes; UP000233100; Chromosome 19.
DR   Bgee; ENSMFAG00000003765; Expressed in skeletal muscle tissue and 10 other cell types or tissues.
DR   CDD; cd08320; Pyrin_NALPs; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF20; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 7; 1.
DR   Pfam; PF13516; LRR_6; 1.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM00368; LRR_RI; 6.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT   DOMAIN          1..93
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          226..465
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   963 AA;  109665 MW;  002E0E1BBF11F845 CRC64;
     MTSPQLEWTL QTLLEQLNED ELKSFKSLLR ALPLEDVLQK APWSEVEEAD GKKLAEILIH
     TSSENWIRSA TVTVLEEMNL TELCKMAKSE MLEAGQVQEI DNPQLGDAEE DSELEKPGGQ
     GVKFVWKQSL VWKNTFWQGD IDSFHDDVIQ RNQRFIPFLN PSTPSFVTLT VSMVTLAKLD
     WTDCNLSPTV RYAFYLNCKE LSRMGPCSFA ELISKDWPEL QDDIPSILAQ AQRILFVVDG
     LDELKVPPGA LIQDICGDWE QQKPVPVLLG SLLKRKMLPK ATLLVTTRPR ALRDLQLLVQ
     QPIYIRVEGF LEEDRRAYFL RHFGDEDQAM RAFELMRSNA ALFQLGSAPA VCWIVCTTLK
     LKMEKGEDPA PTCLTSTRLF LRFLCSQFAR AQLGLRWLSL LAAQGLWAQM SVLHGEDLES
     AGVQESDLRL FLDRNILRQD GVAKGCYSFI HLSFQQFLTA LFYALEKEEE EDRDGHAWDI
     GDVQKLLSRE ERLKNPDLIQ AGHFLFGLAN EKRVKELEAT FGCQMSPEIK QELLRCKGSL
     HADKPLSMTD LKEVLCCLYE SQEEELAKVV VAPLKKISIN LTNTSEMMHC SFSLKHCRDL
     EKVSLQIAKG VFLENYVDFE ADIEFERCTY VTLPSWAQQD LRSLRLWTDF CALFSSNSNL
     KFLEVKQSFL SDSSVRILCD HITRSTCHLQ KVEIKNVTPD TAYRDFCLAF IGKRTLTHLT
     LEGHIEWERT MLLLLCDLLR NHKCNLQYLR LGGHCATSEQ WVDFFYVLKA NQSLRHLHLS
     ASVLLDEGAK LLYKTMTHPK HFLQMLSLEN CRLTEASCKD LAAVLVVSQQ LTHLCLAKNP
     IGDTGVKFLC EGLSYPECKL QALVLQQCSI TKRGCRYLSE ALQEACSLTN LDLSLNQIAR
     GLWILCQALE NPNCNLKHLR LKTYETNLEI KKLLEEVKEK NPKLTIDCNA SGATAPACCD
     FFC
//