ID   A0A2K5WCD7_MACFA        Unreviewed;       399 AA.
AC   A0A2K5WCD7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Aminopeptidase O (putative) {ECO:0000313|Ensembl:ENSMFAP00000034777.2};
GN   Name=AOPEP {ECO:0000313|Ensembl:ENSMFAP00000034777.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000034777.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000034777.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000034777.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5WCD7; -.
DR   Ensembl; ENSMFAT00000009007.2; ENSMFAP00000034777.2; ENSMFAG00000003845.2.
DR   VEuPathDB; HostDB:ENSMFAG00000003845; -.
DR   GeneTree; ENSGT00940000155211; -.
DR   Proteomes; UP000233100; Chromosome 15.
DR   Bgee; ENSMFAG00000003845; Expressed in heart and 13 other cell types or tissues.
DR   GO; GO:0005730; C:nucleolus; IEA:InterPro.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.30.2010.30; -; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   InterPro; IPR033577; AOPep.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR015211; Peptidase_M1_C.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   PANTHER; PTHR46627; AMINOPEPTIDASE O; 1.
DR   PANTHER; PTHR46627:SF1; AMINOPEPTIDASE O; 1.
DR   Pfam; PF09127; Leuk-A4-hydro_C; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   SMART; SM01263; Leuk-A4-hydro_C; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..399
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030052073"
FT   DOMAIN          231..349
FT                   /note="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase
FT                   C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01263"
FT   REGION          353..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   399 AA;  45744 MW;  C48826005401017A CRC64;
     SWLKTLLQLI PPCLSAAHSV LGTHPFSRLD VLIVPANFPS LGMASPHIMF LSQSILTGGS
     HLCGTRLCHE IAHAWFGLAL GARDWTEEWL SEGFASHLED VFWAAAQQLA PHEAREQQEL
     RACLRWRRLQ DEMQSSPAEM QVLRPNKDKT GHTSDSGASV IKHGLNPEKS FMQVHYLKGY
     FLLRFLAERL GDETYFSFLR KFVHAFHGQL ILSQDFLQML LENIPEEKRL ELSVENIYQD
     WLESSGIPKL LPDQLVLLLE HLLEQKTLSH RTLQSLQRTY HLQDQDAEVR HRWCELIVKH
     KFTKAYESVE RFLQEDQERP QRDSFIHLLL AWGTGPGHQR RDYVAAKAVS PQPRSSLGAS
     LSQRLVPARH AQKADSHKRG LPPWIWSGAA LGFRVLLHR
//