ID A0A2K5WCZ4_MACFA Unreviewed; 650 AA.
AC A0A2K5WCZ4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Macrophage stimulating 1 {ECO:0000313|Ensembl:ENSMFAP00000034994.2};
GN Name=MST1 {ECO:0000313|Ensembl:ENSMFAP00000034994.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000034994.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000034994.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000034994.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily.
CC {ECO:0000256|PIRNR:PIRNR001152}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00121}.
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DR RefSeq; XP_015301398.1; XM_015445912.1.
DR AlphaFoldDB; A0A2K5WCZ4; -.
DR STRING; 9541.ENSMFAP00000034994; -.
DR Ensembl; ENSMFAT00000009227.2; ENSMFAP00000034994.2; ENSMFAG00000003952.2.
DR GeneID; 102121457; -.
DR KEGG; mcf:102121457; -.
DR CTD; 4485; -.
DR VEuPathDB; HostDB:ENSMFAG00000003952; -.
DR GeneTree; ENSGT00940000159461; -.
DR OrthoDB; 211181at2759; -.
DR Proteomes; UP000233100; Chromosome 2.
DR Bgee; ENSMFAG00000003952; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00108; KR; 4.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR Gene3D; 2.40.20.10; Plasminogen Kringle 4; 4.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR024174; HGF/MST1.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR PANTHER; PTHR24261:SF12; HEPATOCYTE GROWTH FACTOR-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR24261; PLASMINOGEN-RELATED; 1.
DR Pfam; PF00051; Kringle; 4.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF001152; HGF_MST1; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR PRINTS; PR00018; KRINGLE.
DR SMART; SM00130; KR; 4.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57414; Hairpin loop containing domain-like; 1.
DR SUPFAM; SSF57440; Kringle-like; 4.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS00021; KRINGLE_1; 3.
DR PROSITE; PS50070; KRINGLE_2; 4.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00121};
KW Kringle {ECO:0000256|ARBA:ARBA00022572, ECO:0000256|PROSITE-
KW ProRule:PRU00121}; Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Serine protease homolog {ECO:0000256|PIRNR:PIRNR001152}.
FT DOMAIN 48..125
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 129..207
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 221..300
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 308..387
FT /note="Kringle"
FT /evidence="ECO:0000259|PROSITE:PS50070"
FT DOMAIN 423..648
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DISULFID 130..207
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 151..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 179..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 243..282
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
FT DISULFID 271..294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00121"
SQ SEQUENCE 650 AA; 73728 MW; 5BAB8D87889BED01 CRC64;
MLRGPWAFHY NVSSHGCQLL PWTQHSPHTR LRHSGRCDLF QKKDYIRTCI MDNGVGYRGT
VATTVDGLPC QAWSHKFPND HRYTPTLRNG LEENFCRNPD GDPGGPWCYT TNPAVRFQSC
GIKSCREAAC VWCNGEDYRG AVDRTESGRE CQRWDLQHPH QHPFEPGKFL DQGLDDNYCR
NPDGSERPWC YTTDPQLERE FCDLPRCGSE AQPRHEATTV SCFRGKGEGY RGTANTTTAG
VPCQRWDAQI PHQHRFTPEK YACKDLRENF CRNPDGSEAP WCFTLRPGMR MAFCYQIRRC
ADDVRPQDCY HGTGEQYRGT VSKTRKGVQC QRWSAETPHK PQFTFTPEPH AQLEENFCRN
PDGDSHGPWC YTMDPGTPFD YCALRRCADD QPPSILDPPD QVQFEKCGKR VDRLDQRRSK
LRVVGGHPGN SPWTVSLRNR QGQHFCGGSL VKEQWILTAR QCFSSCHMPL MGYEVWLGTL
FQNPQHGEPG LQRVPVAKMV CGPSGSQLVL LKLERSVTLN QRVALICLPP EWYVVPPGTK
CEIAGWGETK GTGNDTVLNV ALLNVISNQE CNIKHRGRVR ESEMCTDGLL APVGACEGDY
GGPLACFTHN CWVLEGIIIP NRVCARSRWP AVFTRVSVFV DWIHKVMRLA
//
