ID A0A2K5WDD9_MACFA Unreviewed; 577 AA.
AC A0A2K5WDD9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=RRM domain-containing protein {ECO:0000259|PROSITE:PS50102};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000035118.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000035118.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000035118.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|RuleBase:RU003707}.
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DR AlphaFoldDB; A0A2K5WDD9; -.
DR STRING; 9541.ENSMFAP00000035118; -.
DR Ensembl; ENSMFAT00000009353.2; ENSMFAP00000035118.2; ENSMFAG00000043091.2.
DR VEuPathDB; HostDB:ENSMFAG00000003935; -.
DR GeneTree; ENSGT00940000159610; -.
DR Proteomes; UP000233100; Chromosome 19.
DR Bgee; ENSMFAG00000043091; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0043484; P:regulation of RNA splicing; IEA:UniProt.
DR CDD; cd06558; crotonase-like; 1.
DR CDD; cd12699; RRM3_hnRNPL; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 1.10.12.10; Lyase 2-enoyl-coa Hydratase, Chain A, domain 2; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045002; Ech1-like.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR InterPro; IPR006536; HnRNP-L/PTB.
DR InterPro; IPR034816; hnRNP-L_RRM3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01649; hnRNP-L_PTB; 1.
DR PANTHER; PTHR43149:SF1; DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43149; ENOYL-COA HYDRATASE; 1.
DR Pfam; PF00378; ECH_1; 1.
DR Pfam; PF13893; RRM_5; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
DR PROSITE; PS50102; RRM; 1.
PE 3: Inferred from homology;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 86..160
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..81
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 63430 MW; 07746A2EAD7779E8 CRC64;
MVTLAATPTN ARGSPLSWEI TPQNMEGPTV GTTAITMMRA TGPPHLTTKG EGWVHQWGSP
GPKYGPQYGH PHPSPPPEYG PHADSPVLMV YGLDQSKMNC DRVFNVFCLY GNVEKVKFMK
SKPGAAMVEM ADGYAVDRAI THLNNNFMFG QKLNVCVSKQ PAIMPGQSYG LEDGSCSYKD
FSESRNNRFS TPEQAAKNRI QHPSNVLHFF NAPLEVTEEN FFEICDELGV KRPSSVKVFS
GKSERSSSGL LEWESKSDAL ETLGFLNHYQ MKNPRLTASN YSGLSISLRL TGSSAQEEAP
DHSYESLRVT SAQKHVLHVQ LNRPNKRNAM NKAFWREMVE CFNKISRDAD CRAVVISGAG
KMFTAGIDLM DLASDILQPK GDDVARISWY LRDIITRYQE TFSVIEKCPK PVIAAVHGGC
IGGGVDLITA CDIRYCAQDA FFQVKEVDVG LAADVGTLQR LPKVIGNQSL VNELAFTARK
MMADEALGCG LVSRVFPDKE VMLDAALALA AEISSKSPVA VQSTKVNLLY SRNHSVAESL
NYVASWNMSM LQTQDITKSV QAVTENKELK SVTFSKL
//
