ID A0A2K5WDR7_MACFA Unreviewed; 326 AA.
AC A0A2K5WDR7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Calcipressin-2 {ECO:0000256|ARBA:ARBA00015789};
DE AltName: Full=Regulator of calcineurin 2 {ECO:0000256|ARBA:ARBA00029914};
GN Name=RCAN2 {ECO:0000313|Ensembl:ENSMFAP00000035277.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000035277.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000035277.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000035277.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC binding to the catalytic domain of calcineurin A. Could play a role
CC during central nervous system development.
CC {ECO:0000256|ARBA:ARBA00024927}.
CC -!- SIMILARITY: Belongs to the RCAN family.
CC {ECO:0000256|ARBA:ARBA00008209}.
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DR AlphaFoldDB; A0A2K5WDR7; -.
DR Ensembl; ENSMFAT00000009512.2; ENSMFAP00000035277.2; ENSMFAG00000036451.2.
DR VEuPathDB; HostDB:ENSMFAG00000036451; -.
DR GeneTree; ENSGT00940000159767; -.
DR OrthoDB; 2727072at2759; -.
DR Proteomes; UP000233100; Chromosome 4.
DR Bgee; ENSMFAG00000036451; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:InterPro.
DR CDD; cd12709; RRM_RCAN2; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR006931; Calcipressin.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034919; RCAN2_RRM.
DR PANTHER; PTHR10300; CALCIPRESSIN; 1.
DR PANTHER; PTHR10300:SF5; CALCIPRESSIN-2; 1.
DR Pfam; PF04847; Calcipressin; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT REGION 12..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..79
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..310
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 326 AA; 36304 MW; C5DAF4E56902BC84 CRC64;
MSRSWGRAHL RRLLREPPAQ PLPGAALSRV TAAEVAGRSG QHAETHRPTA AESGRQGAPR
RVRPHAQARG HRTAPTRSHR RAGMRGESYF IGMRSPGQQG HIPEDGGLFL LCCIDRDWAV
TRCFAEEAFQ AITDFNDLPN SLFACNVHQS VFEGEDSKEK FEGLFRTYDD CVTFQLFKSF
RRVRINFSNP KSAARARIEL HETQFRGKKL KLYFAQVQTP ETDGDKLHLA PPQPAKQFLI
SPPSSPPVGW QPINDATPVL NYDLLYAVAK LGPGEKYELH AGTESTPSVV VHVCDSDIEE
EEDPKTSPKP KIIQTRRPGL PPSVSN
//
