ID A0A2K5WE97_MACFA Unreviewed; 1481 AA.
AC A0A2K5WE97;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=PZP alpha-2-macroglobulin like {ECO:0000313|Ensembl:ENSMFAP00000035349.2};
GN Name=PZP {ECO:0000313|Ensembl:ENSMFAP00000035349.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000035349.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000035349.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000035349.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. {ECO:0000256|ARBA:ARBA00010952}.
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DR Ensembl; ENSMFAT00000009585.2; ENSMFAP00000035349.2; ENSMFAG00000036700.2.
DR VEuPathDB; HostDB:ENSMFAG00000035486; -.
DR GeneTree; ENSGT00940000163609; -.
DR Proteomes; UP000233100; Chromosome 11.
DR Bgee; ENSMFAG00000036700; Expressed in liver and 1 other cell type or tissue.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR010916; TonB_box_CS.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR PANTHER; PTHR11412:SF92; PREGNANCY ZONE PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
PE 3: Inferred from homology;
KW Bait region {ECO:0000256|ARBA:ARBA00023248};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1481
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030052108"
FT DOMAIN 455..603
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 745..835
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1383..1470
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
SQ SEQUENCE 1481 AA; 163343 MW; 0E4927B571B7FC7A CRC64;
MGKDRLLHLC LMLLLILLSA NDSNSAEPQY MVLVPSLLHT EAPEKGCVLL SHLNETVTVS
ASLESGGENR SLFTDLVAEK DLFHCVVFTL PRISASSEVA FLSIRIKGPT QDFRKRNTVL
VKNTQSLVFV QTDKPVYKPE QTVRFRVVSV DENFRPRNEL IPVIYLENPR RNRIAQWQSL
TLEGGLNQLS FPLSSEPIQG SYKVVVQTES GGRIEHPFTV EEFVLPKFEV KVQVPKIISI
VDEKVNITVC GKYTYGKPVP GLATVSLCRK FFHVPNCDKH EVCEEFSQQL NSNGCVTQQV
HTKMLQIKNM GFEMKLRVEA RIREEGTDLV VTANGISEIT NIASKLIFVK VDSHFRQGIP
FFGQVLLVDG KGVPIPNKLI FISASEANYF SNATTNEQGL AQFSINTTHI LANKLFVQVY
TVHPNLCFHY SWVTEEHQGA QHTANHVFSL SGSYIHLEPV AGTLPCGHTQ NIRTHYILNI
QAVGELSELS FHYLIMAKGG IVRSGTHTLP VESGDMKGSF ALSFPVESDI APIARMFIFA
ILPDGEVIGD SEKFEIENCL ANKVDLSFSP AQSPPASHAH LRVGAAPQSL CALRAVDQSM
LLMKTEAELS ASSVYNLLTV KDLTNFPDNV DHQEEEQGHC PHPFFIRNGA FYVPLSSNDE
ADIYSFLKGM GLKVFTNSKI RKPKSCSVIP PMSAGVISQG YYGVGLGVAG RPYPPQMSAY
NIMPLNNEQS SGPVPETVRS YFPETWIWEL VAVDSSGVAE VGVTVPDTIT DWKAGAFCLS
QDSGLGISPT ASLRAFQPFF VELTMPYSVI RGEAFTLKAT VLNYLPKCIR VSVQLEASPA
FLAVPVEKEQ EPHCICANGR QTVSWAITPK SLGNVNFTVS AEALESQELC GTEVASVPQY
GKKDTIIKPL LVEPEGLEKE TTFNSLLCPS GGEVSEELSL KLPPNVVEES ARASVSVLGD
ILGSAMQNIQ NLLQMPYGCG EQNMVLFAPN IYVLDYLNET QQLTPEIESK AIGYLNTGYQ
RQLNYKHYDG SYSTFGERYG RNQGNTWLTA FVLKTFAQAR AYIFIDEAHI TQALIWLSQK
QKDNGCFRSS GSLLNNAIKG GVEDEVTLSA YITIALLEIP LPVTHPVVRN ALFCLESAWK
TTQEGAHGSH VYTKALLAYA FALAGNQEKR KEVLESLNEE AVKKDNSVHW ERPQKPKAPV
GHFYEPQAPS AEVEMTSYVL LAYLTAQPAP TSEDLTSATN VVKWITKQQN SQGGFSSTQD
TVVALHALSK YGAATFTRTG KAAQVTIQSS GTFSNKFQVD NSNRLLLQRV SLLELPGEYS
MKVTGEGCVY LQTSLKYNIL PEKEEFPFAL GVQTLPATCE EPKAHTSFQI SLSVSYTGSR
SASNMAIVDV KMVSGFIPLK PTVKTLERSN HVSRTEVSNN HVLIYLDKVS NQTLSLFFTV
LQDVPVRDLK PAIVKVYDYY ETDEFAIAEY NAPCSKDLGN A
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