ID A0A2K5WID2_MACFA Unreviewed; 638 AA.
AC A0A2K5WID2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Propionate--CoA ligase {ECO:0000256|ARBA:ARBA00029726};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.17 {ECO:0000256|ARBA:ARBA00012985};
GN Name=ACSS2 {ECO:0000313|Ensembl:ENSMFAP00000036897.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000036897.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000036897.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000036897.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA;
CC Xref=Rhea:RHEA:20373, ChEBI:CHEBI:17272, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392,
CC ChEBI:CHEBI:456215; EC=6.2.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000787};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20374;
CC Evidence={ECO:0000256|ARBA:ARBA00000787};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001884};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23177;
CC Evidence={ECO:0000256|ARBA:ARBA00001884};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR AlphaFoldDB; A0A2K5WID2; -.
DR Ensembl; ENSMFAT00000011146.2; ENSMFAP00000036897.2; ENSMFAG00000037662.2.
DR VEuPathDB; HostDB:ENSMFAG00000037662; -.
DR GeneTree; ENSGT00940000156358; -.
DR OrthoDB; 144557at2759; -.
DR Proteomes; UP000233100; Chromosome 10.
DR Bgee; ENSMFAG00000037662; Expressed in colon and 13 other cell types or tissues.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF126; ACETYL-COENZYME A SYNTHETASE, CYTOPLASMIC; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 14..63
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 71..429
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 520..598
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 638 AA; 71900 MW; CE8BF04E021B5399 CRC64;
MSEKINDIWA SISIAEFWGD IAKEFYWKTP CPGPFLRYNF DVTKGKIFIE WMKGASTNIC
YNVLDRNVHE KKLGDKVAFY WEGNEPGETT QITYHELLVQ VCQFSNVLRK QGIQKGDRVA
IYMPMIPELV VAMLACARIG ALHSIVFAGF SSESLCERIL DSSCSLLITT DAFYRGEKLV
NLKELADEAL QKCQEKDFPV RCCIVVKHLG RAELGMGDSP SQSPPIKRSC PDVQISWNQG
IDLWWHELMQ EAGDECEPEW CDAEDPLFIL YTSGSTGKPK GVVHTVGGYM LYVATTFKYV
FDFHAEDVFW CTADIGWITG HSYVTYGPLA NGATSVLFEG IPTYPDVNRL WSIVDKYKVT
KFYTAPTAIR LLMKFGDEPV TKHSRASLQV LGTVGEPINP EAWLWYHQVV GAQRCPIVDT
FWQTETTFPF FGVAPAILNE SGEELEGEAE GYLVFKQPWP GIMRTVYGNH ERFETTYFKK
FPGYYVTGDG CRRDQDGYYW ITGRIDDMLN VSGHLLSTAE VESALVEHEA VAEAAVVGHP
HPVKGECLYC FVTLCDGHTF SPKLTEELKK QIREKIGPIA TPDYIQNAPG LPKTRSGKIM
RRVLRKIAQN DHDLGDTSTV ADPSVISHLF SHRCLTIQ
//
