ID A0A2K5WIY3_MACFA Unreviewed; 215 AA.
AC A0A2K5WIY3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Neuroblastoma suppressor of tumorigenicity 1 {ECO:0000256|ARBA:ARBA00015324};
GN Name=NBL1 {ECO:0000313|Ensembl:ENSMFAP00000037011.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000037011.1, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000037011.1, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000037011.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the DAN family. {ECO:0000256|ARBA:ARBA00007872}.
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DR RefSeq; XP_005544634.1; XM_005544577.2.
DR AlphaFoldDB; A0A2K5WIY3; -.
DR Ensembl; ENSMFAT00000011261.2; ENSMFAP00000037011.1; ENSMFAG00000037763.2.
DR VEuPathDB; HostDB:ENSMFAG00000037763; -.
DR GeneTree; ENSGT00940000154209; -.
DR OMA; ECPGHEV; -.
DR OrthoDB; 3684148at2759; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000037763; Expressed in colon and 13 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0036122; F:BMP binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0016015; F:morphogen activity; IEA:Ensembl.
DR GO; GO:0048263; P:determination of dorsal identity; IEA:Ensembl.
DR GO; GO:0090027; P:negative regulation of monocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0038098; P:sequestering of BMP from receptor via BMP binding; IEA:Ensembl.
DR GO; GO:0035582; P:sequestering of BMP in extracellular matrix; IEA:Ensembl.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR004133; DAN.
DR InterPro; IPR016728; Neuroblast_suppress_tumour_1.
DR PANTHER; PTHR15283; GREMLIN 1; 1.
DR PANTHER; PTHR15283:SF5; NEUROBLASTOMA SUPPRESSOR OF TUMORIGENICITY 1; 1.
DR Pfam; PF03045; DAN; 1.
DR PIRSF; PIRSF018557; DAN_sub; 1.
DR SMART; SM00041; CT; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 71..158
FT /note="CTCK"
FT /evidence="ECO:0000259|SMART:SM00041"
FT REGION 166..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..202
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 215 AA; 23235 MW; FEF09E5ADD1738A8 CRC64;
MCSPALQQLI SMDLFWRLFL VCGQEGLRAL EATGMMLRVL MGAVLPAMLL AAPPPINKLA
LFPDKSAWCE AKNITQIVGH SGCEAKSIQN RACLGQCFSY SVPNTFPQST ESLVHCDSCM
PAQSMWEIVT LECPGHEEVP RVDKLVEKIL HCSCQACGKE PSHEGLSVYV QGEDGPGSQP
GTHPHPHPHP HPGGQTPEPE EPPGAPHTEE EGAED
//
