ID A0A2K5WK85_MACFA Unreviewed; 414 AA.
AC A0A2K5WK85;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Serpin family A member 5 {ECO:0000313|Ensembl:ENSMFAP00000037572.2};
GN Name=SERPINA5 {ECO:0000313|Ensembl:ENSMFAP00000037572.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000037572.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000037572.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000037572.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR AlphaFoldDB; A0A2K5WK85; -.
DR STRING; 9541.ENSMFAP00000037572; -.
DR Ensembl; ENSMFAT00000011823.2; ENSMFAP00000037572.2; ENSMFAG00000038025.2.
DR VEuPathDB; HostDB:ENSMFAG00000038025; -.
DR GeneTree; ENSGT00940000162217; -.
DR Proteomes; UP000233100; Chromosome 7.
DR Bgee; ENSMFAG00000038025; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0002080; C:acrosomal membrane; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0031091; C:platelet alpha granule; IEA:Ensembl.
DR GO; GO:0031094; C:platelet dense tubular network; IEA:Ensembl.
DR GO; GO:0097181; C:protein C inhibitor-coagulation factor V complex; IEA:Ensembl.
DR GO; GO:0097182; C:protein C inhibitor-coagulation factor Xa complex; IEA:Ensembl.
DR GO; GO:0097183; C:protein C inhibitor-coagulation factor XI complex; IEA:Ensembl.
DR GO; GO:0036029; C:protein C inhibitor-KLK3 complex; IEA:Ensembl.
DR GO; GO:0036030; C:protein C inhibitor-plasma kallikrein complex; IEA:Ensembl.
DR GO; GO:0036026; C:protein C inhibitor-PLAT complex; IEA:Ensembl.
DR GO; GO:0036027; C:protein C inhibitor-PLAU complex; IEA:Ensembl.
DR GO; GO:0036028; C:protein C inhibitor-thrombin complex; IEA:Ensembl.
DR GO; GO:0036025; C:protein C inhibitor-TMPRSS11E complex; IEA:Ensembl.
DR GO; GO:0036024; C:protein C inhibitor-TMPRSS7 complex; IEA:Ensembl.
DR GO; GO:0032190; F:acrosin binding; IEA:Ensembl.
DR GO; GO:0031210; F:phosphatidylcholine binding; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0001972; F:retinoic acid binding; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd19553; serpinA5_PCI; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF274; PLASMA SERINE PROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..414
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030790534"
FT DOMAIN 60..414
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 414 AA; 46521 MW; FAFA9E807D0CE490 CRC64;
MVGTEQRTAA MQLFLLLCLV LLSPQEASLH RHHPRETKKR VKDLHVGATV APSSRRDFTF
DLYRALASAA PSQNVFFSPV SISVSLAMLS LGAGSSTKRQ ILEGLGLDLQ KSSEEQLHRG
FQQLLQELNQ PRDGFQLSLG NALFTDLVVD VQDTFMSAMK TLYLADSFPT NFGDSAGALK
QINDYVAKQT KGKIVDLLKN LDSNAVMVMV NYIFFKAKWE TSFNHKGTQE QDFYVTPETV
VRVPMMSRED QYHYLLDRNL SCRVVGVPYQ GNATALFILP SEGKMQQVEN GLSEKTLRKW
LKMFKKRQLE LYLPKFSIEG SYQLDKILPK LGISNVFTSH ADLSALTTHL IHLSMVHKAV
VEVDESGTRA AAATGTIFMF RSARLSSQKI VFNRPFLMFI VDNDILFLGK VNRP
//
