ID A0A2K5WL79_MACFA Unreviewed; 1431 AA.
AC A0A2K5WL79;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=FYVE, RhoGEF and PH domain containing 6 {ECO:0000313|Ensembl:ENSMFAP00000037877.1};
GN Name=FGD6 {ECO:0000313|Ensembl:ENSMFAP00000037877.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000037877.1, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000037877.1, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000037877.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR RefSeq; XP_005571945.1; XM_005571888.2.
DR SMR; A0A2K5WL79; -.
DR STRING; 9541.ENSMFAP00000037877; -.
DR Ensembl; ENSMFAT00000012129.2; ENSMFAP00000037877.1; ENSMFAG00000038155.2.
DR GeneID; 102139356; -.
DR KEGG; mcf:102139356; -.
DR CTD; 55785; -.
DR VEuPathDB; HostDB:ENSMFAG00000038155; -.
DR GeneTree; ENSGT00940000156334; -.
DR OrthoDB; 5385125at2759; -.
DR Proteomes; UP000233100; Chromosome 11.
DR Bgee; ENSMFAG00000038155; Expressed in lung and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15743; FYVE_FGD6; 1.
DR CDD; cd15793; PH1_FGD6; 1.
DR CDD; cd13237; PH2_FGD5_FGD6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR037743; FGD6_N_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF12; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 872..1061
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1090..1184
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1223..1282
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1334..1430
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..538
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..870
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1293..1307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1431 AA; 160957 MW; 3B301A8CB1E4952E CRC64;
MTSAAEMKKP PVAPKPKFVV ANNKPTPPPI APKPDIVISS VPQSTKKMKP AIAPKPKVLK
SSPVRDIGQS PSRKIMLNLE GHKQELAEST DNFNCKYEGD QSSDYISPVC SCSSECIHKM
GHRENLCVKQ LVLEPLEMNE NLENSKIDET LTIQTRSKCD LYGEKAKNQG GVVLKASILE
EKLKDALIHR MPPFISAQKH RSTDSPEMNG GCNSDGQFRI EFTDLSPSPS SFEKVPDHHS
CHLQLPSDEC ENFETCQDDS EKSNNCFQSS ELEALENGKR STFISSDEVS KKSIVKDLGP
LEIHLLPYTP KFPTPKPRKT RTARLLRQKC VDTPSESTEE PGNSDSSSSC LTENSLKMNK
ISVLHQNVLC KQEQVDTVKL GNKSELNMES NSDAQDLVNS QKVMCHEISS FEKMAPSFDT
DSNLSSDSTT VDGSSMSLAV DEGTGFIRCS TLSMSLPKQL KLTCNEHLQS ERNLGVSAPQ
MQKESVIKEE NSLRIVPKKP QRHSLPATGV LKKAASEELV EKSSYPSSEE KSSEKGLERN
HLQHLCAQNR GVSSSSDMPK RASEKPVWKL PHPILPFSGN PESLKSVTLS SNSEPSTALT
KPRAKSLSAV DVEKCTKPCK DSAKKNSFKK LLNMKLSICF MKSDFQKFWS KSSQLGDTTT
GHLSSGEQKG IESDWQGLLV GEEKRSKPIK AYSTENYSLE SQKKRKKSRG QTSAANGLRA
ESLDDQMLSR ESSSQAPYKS VTSLCAPEYE NIRHYEEIPE YENLPFIMAI QKTRELEWQN
SSSVEDTDAN VYEVEEPYEA PDGQLQLGPR HQHSSSGASQ EEQNHLGLGD LPSDEEEVIN
SSDEDDVSSE SSKGEPDPLD DKQDEDNGMK SKVHHIAKEI MSSEKVFVDV LKLLHIDFRD
AVAHASRQLG KPVIEDRILN QILYYLPQLY ELNRDLLKEL EERMLHWTEQ QRIADIFVKK
GPYLKMYSTY IKEFDKNIAL LDEQCKKNPG FAAVVREFEM SPRCANLALK HYLLKPVQRI
PQYRLLLTDY LKNLIEDAGD YRDTQDALAV VIEVANHAND TMKQGDNFQK LMQIQYSLNG
HHEIVQPGRV FLKEGILMKL SRKVMQPRMF FLFNDALLYT TPVQSGMYKL NNMLSLAGMK
VRKPTQEAYQ NELKIESVER SFILSASSAT ERDEWLEAIS RAIEEYAKKR ITFCPSRSLD
EADSENKEEV SPLGSKAPIW IPDTRATMCM ICTSEFTLTW RRHHCRACGK IVCQACSSNK
YGLDYLKNQP ARVCEHCFQE LQKLDHQHSP RIGSPGNHKS PSSALSSVLH SIPSGRKQKK
IPAALKEVSA NTEDSSMSGY LYRSKGNKKP WKHFWFVIKN KVLYTYAASE DVAALESQPL
LGFTVIQVKD ENSESKVFQL RHKNMLFYLF KAEDAHSAQK WIEAFQEGTI L
//
