ID A0A2K5WLW8_MACFA Unreviewed; 4699 AA.
AC A0A2K5WLW8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=StAR related lipid transfer domain containing 9 {ECO:0000313|Ensembl:ENSMFAP00000038027.2};
GN Name=STARD9 {ECO:0000313|Ensembl:ENSMFAP00000038027.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000038027.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000038027.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000038027.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR STRING; 9541.ENSMFAP00000038027; -.
DR Ensembl; ENSMFAT00000012279.2; ENSMFAP00000038027.2; ENSMFAG00000040647.2.
DR VEuPathDB; HostDB:ENSMFAG00000040647; -.
DR GeneTree; ENSGT00940000164290; -.
DR OrthoDB; 126886at2759; -.
DR Proteomes; UP000233100; Chromosome 7.
DR Bgee; ENSMFAG00000040647; Expressed in lung and 11 other cell types or tissues.
DR GO; GO:0005814; C:centriole; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0003777; F:microtubule motor activity; IEA:Ensembl.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0051225; P:spindle assembly; IEA:Ensembl.
DR CDD; cd22731; FHA_KIF16A_STARD9; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd08874; START_STARD9-like; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR PANTHER; PTHR47117:SF1; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF01852; START; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50848; START; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 3..384
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 4564..4699
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
FT REGION 310..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 858..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1061..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1297..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1667..1688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2002..2040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2063..2175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2251..2273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2375..2399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2484..2513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2624..2655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2762..2783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2805..2846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2886..2951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3055..3077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3116..3145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3200..3238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3273..3411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3574..3617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3697..3739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3767..3790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3803..3883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3914..3967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4026..4079
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4151..4192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4393..4418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4339..4370
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 310..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..883
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2080..2097
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2099..2120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2130..2152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2252..2266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2487..2511
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2805..2828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3055..3074
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3116..3131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3200..3217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3273..3291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3313..3347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3368..3383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3721..3739
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3803..3820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3838..3868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3946..3967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4048..4078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4168..4192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 103..110
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 4699 AA; 514306 MW; CB011B6D2265A25A CRC64;
MANVRVAVRV RPLSKRETKE GGRIIVEVDG KVAKIRNLKV DSRPDGFGDS REKVMAFGFD
YCYWSVNPED PQYASQDVVF QDLGMEVLSG VAKGYNICLF AYGQTGSGKT YTMLGTPASV
GLTPRICEGL FIREKDCASL PSSCRIKVSF LEIYNERVRD LLKQSGQKKP YTLRVREHPE
MGPYVQGLSQ HVVTNYKQVI QLLEEGIANR ITAATHVHEA SSRSHAIFTI HYTQAILENN
LPSEMASKIN LVDLAGSERA DPSYCKDRIT EGANINKSLV TLGIVISTLA QNSQVFSSCQ
SLNSSVSNGG DSGILSSPSG TSSGGAPSRR QSYIPYRDSV LTWLLKDSLG GNSKTIMVAT
VSPAHTSYSE TMSTLRYASS AKNIINKPRV NEDANVKLIR ELREEIERLK ALLLSFELRN
FGSLNDEKDE NLKELVLQNE LKIDQLTKDW TQKWNDWQAL MEHYSVDINR RRAGVVIDSS
LPHLMALEDD VLSTGVVLYH LKEGTTKIGR IDSDQEQDIV LQGQWIERDH CTITSACGVV
VLRPARGARC TVNGREVTAS CRLTQGAVIT LGKAQKFRFN HPAEAAVLRQ RRQVGEAAAG
GGSLEWLDLD GDLTASRLGL FPLLWKEGRA LEEQCDEDRQ PPRDGETSHR AQIQQQQSYV
EDLRHQILAE EIQAEKELEF DQSWISQQIK ENQQCLLREE TWLASLQQQQ QEDHVAEKEL
EASVALDAWL QTDPEIQPSP FVQSQKRVVQ LQLLRRHTLR AAERNVRRKK VSFQLERIIK
KQRLLEAQKR LEQLTTLCWL QDDSTQEPPY QVPSPDATVP RPQCRSKLTS CSSLSPQRLC
SKHVPQLHSI FLSWDPSTTL PPMPDPTHQT SEKTSSEECL SQAASYPPRT GCLRKNGLHS
SGHGQPCTAR AALSRKGASA PDTWLTVSPN SVGIQEMERV GKQPHQMVIQ GLASLRKSAN
KLKPRHEPKI LTSTTQTRRA KGLADPSHTQ AGWRKEGNLG THTAAKGASC NSPYPHGPRQ
TAGHGKAVKT FCTEYKPPSL SRASKRHQRV LAARVRNITK KSSHLPLGSP LKRQQNTRDL
DTMAPLTDFS PVVDHSREDN DFSDSDSNYS VDSLSCVYAK ALIEPLKPED PQERKWDFPE
PENSESDDSQ ISEDSLAEKR YQSPQNRLGG NHPTNHHGHP RTRARASVRG FTAPSDSDLL
AQTHRSFSLD SLIDAEEELA EDQQEEPCPG SADEIPTETF WHLEDSNLPV MDQEAICRLG
PINYRTAARL DAVLPMSSSF YLDPQFQPRC ELQPHCEQAE SQGEPSYSEQ ANSLQGMQLS
RESPLMSMDS WFSCDSKINP SSPPGIVGSL CPSPDVQEFH HCKGERPGYW LNTEELKPSD
AETVLPYSSK LHQGSTELLC IARDEHTASA SDMSRLSLWG IQKLIQPGAD GTFQGRCIHD
TTQQGSSEAS HNSSVSNVLS ASATTLTHVG GTHERDWSAL QQKYLLELSC PVLEAIGVPR
PAFPYLEEDS GSLAQASGEG GDTSLPVGPK VSSNLNLNNF PIHLSRIRRL RAEKEQDSLN
AKLEGVSDFF STSEKEVSYD ETYSADLESL AASRSTNAQV FAVGNTIPGS MTEACEVKQN
NLEECLQSCR KPGLMTSSDE YFFQKNACHS NVTTATKADH WPQGWAPLRK NSAVQPGQLS
PDSQYPLEEE KTDCQESSKE AVRRHINISF AFPSGPELYL HSAAWNPLSS SLQPPLLETF
YVTKSRDALT ETALEIPACR EVRVPSPPPR EAWGFGHNHQ ALQDAYLKTN LPVLLQNQNS
KVASSQQVTA EIPVDLNTGE VIRESGKCPG NITEESRDSV YSSVTQNRHF LPSTSTKVCE
FENQVGILNK HSFPALEGGE VTAQSCCSVS SDSTESGKPL LLFLESEACE EEELDQNTVL
RQTINVGLEK DLPWESAVSL KSRSVHHRVS SPGMVAQDES PTPKWEGKNE TRLLEKALHP
KDSSEEFKLP GTKPAYERFQ LVTYPQERNP SECKGPGKSQ GMLNPNGEPS EKKQNKRVNN
TDEMARLIRS VMQLENGILE IESKQNKQVH ASHTPGVDKE SVFQDQKEQE KTDHALRPDS
SGNLLTSKDQ PSSPRQTDAT VFRDSEAGEM EVNSTGNHPQ VQKITLNPFR SREGVQESGP
MRQHTHPAGS DRPARDIFES LGKHTTCREF TNTSFRPQRM KALTRALPLQ PRLERSSENN
GQLVKASASL KEQPWGLGSL EELETVKGFQ ESQVAEHLSS SNQEEPKAQG KVEEMPMQRG
RSLQEENKVT QKLPSLSQLC RDTFFSQETV SPLLSWTEFS TAPPHQDLSN TLPLNSPRRP
RSCLHVPGVL GISSLDCVLD LTMLKIHNSP LVTGVHHQDQ STETRGHSPE GNVRGGSSEA
HTAWCGSVRS MAMRSHSQSG VPESISLGTE DKISASTSPQ DHGKDLRITL LGFSTSKDFA
SEAEVAVQKE IGVSSLNKVS SQPEKRVSFS LEKDNDQASK PRQKAEKETE DLGLTSSVSL
APVSLPRVPS LEPRLLEPSD YASMCLAILE EIRQAKAQRK QLNDFVARGT VLSYCETLLE
PECSSGVSGG PQCKQIELSS SDQTRNEGEA PGFNVASLSA EAGQTDLSTD ERKVQATPLS
ADSFQSLPNT ETDRQPWDPM QAFSHAAPAL DKKHCAGELR QFAGTSEPFI CHSGSSEILE
KKKDATRTLS SVDPLAPDSL LSSPVEGVRR VVSKQVVAAL SSQAPCDDPR VTLHELSQSV
PQETAEGIPA GSQDSSPEHQ EPRALNTTYG EVSGHSLVTA QEEKTAHFES QSVTCDVQNS
TSPSGPKQDH VQCPEASTGF EEGRANAKQD TVLPGALTGV ELEAPTQQCV KWKESVGSGL
TEICRAGSKH SRPTPLPDQR PSPNPEGIGE GAPCRYPREA LHGPVFSRNP EGSRTLSASR
GKESRTLPCR RPCSSQPVAA RSYSCHSSTL LCCRGGDLGK EPFKAALRTV YPPCGVPSRA
CEVDETGETS SRGPDVLLTH GLEPKDVNRE FSITESSTCE PSTVAAILSG AQGCRSPSAS
DVRRTSSFSH SATDGSLGLI GAPEKKVAEN QASTELEATS FPAGMYSEPL RQFRDSSVGD
QNAQVSQTSP EPPATTPGPH TLDLSEGSVE SKLVAEPRHE CFENTTRCFL EKPQFSTELR
DHYCLDSQAK FVARLKHTCS PQEDSRWQEE EQHRDQASGG GEGFTQGMNP LPSDEGGLDS
RQILDARRQE VAVAKPPVSK ILSQGFKDPA TVSLRQNETP QPVSQGPGNL YTGREQPALN
HRGSLPMTAI FSGPERSKSS PTPQISVVSS SRSLQELNLS VEPPSPTDED TQGPHRLWNP
HLRGYSTGKS MARTSLQAED SNQKASSHLD DGTTDHRPLK PATPPYPVPS TLSHMPTPDF
MTSWMSGTLE QGQQGKPEKL GVQVRPENWC SQMDKGMLHF GSSDISPYAL PWHPEEHARI
GWKQYVFGST VNVSCSQKPQ GLTPSNVARC SSMDNGLEDQ NSPLHSHLST YANIRDLSTT
HSSTENAQGS NEAWEVFPGS SSVSLGDPHI LTSSEGVAPT LGHDRRPQFR GPSGEADCLR
SKPRLAEGSA AGPADEIMLP YPSGAGCPVG QTRTNIFEQG TQTLGSRCHQ SSTDISFAQP
EASAASASDL ASWTSMHNLS LHLSQLLHST SELLGSLSQP GVARREQNTK RDVPDKAPQT
LMMDGSTQTT VDEGSQTDLA SPTLRLQASE AEPQGANVIL EGLGSHTSTV SQEEGDVPGV
PQKREAEETA QKMAQLLYLQ EESTPYKPQN PSTPSSHLRF QKAPPRQHLP SVGPSVSDAF
LPPSSQPEES SCIAVSSPSP SPCHSPGLLP STSEYPGDPR VQKKLGPTSA LLVDRASSPI
LTLSASTQEL GLSPGSLTLS APSAHPVEGH QKLDSSPDPV GAPRTPMDNY SQTTDELGGS
QRGGSVLQRS NGRSFLELHS PHNPQQSPKL QFSFLGQHPQ QLQPSTTIGV QSRLLPPPLR
HRSQTLADSF VPEEVASPER GPLSGREPSQ WRSRTENGGE SSASPGEPQR TLDRPSSCGG
LQHLSPCPVS ELTDTAGLRG SALGLPQACQ PEGLLCSSCQ MCMAPEPQHH SLRDLPAHNK
FSNWCGVQKG SPGGVDMTEE ELGASGDLSS EKQEQSTPQP PNDHSQDPEW SQGEQIPLQV
GAQNLSLSVE LTEAKLHHGF GEADALLQVL QSGTGEALAA DEPVISTWKE LHARQKKAIE
TLRRERAERL GNFCRTQSLS PQKQLSLLPN KELFVWDLDL PSRRREYLQQ LRKDVVETTR
SPESVSRSAQ PPSDIELMLR DYQQAHEEAK EEIARARDQL REQTEQEKLR IHQQIVSQLL
REEDKLHTLA NSSSLCTSSN GSLSSGMTSG YNSSPALSGQ LQCPENAGYT NLPDSRDVWI
GDERGGLSAV RKNSAYGRRA SLGSCCCSPS SLTNSGTCFS SSYQDLAKHV VDTSMADVMA
ACSDNLHNLF SCQATAGWNY QGEEQAVQLY YKVFSSTRHG FLGAGVVSQP LSHVWAAVSD
PSLWPLYYKP IQTARLHQRV TNSISLVYLV CNTTLCALKQ PRDFCCVCVE AKEGHLSVMA
AQSVYDTSMP RPSRKMVRGE ILPSAWILQP VTVEGKEVTR VIYLAQVELG APGFPPQLLS
SFIKQQPLVI ARLASFLGS
//
