ID A0A2K5WM13_MACFA Unreviewed; 394 AA.
AC A0A2K5WM13;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Potassium calcium-activated channel subfamily N member 4 {ECO:0000313|Ensembl:ENSMFAP00000038166.2};
GN Name=KCNN4 {ECO:0000313|Ensembl:ENSMFAP00000038166.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000038166.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000038166.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000038166.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A2K5WM13; -.
DR Ensembl; ENSMFAT00000012421.2; ENSMFAP00000038166.2; ENSMFAG00000038433.2.
DR VEuPathDB; HostDB:ENSMFAG00000038433; -.
DR GeneTree; ENSGT00950000182904; -.
DR Proteomes; UP000233100; Chromosome 19.
DR Bgee; ENSMFAG00000038433; Expressed in bone marrow and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR004178; CaM-bd_dom.
DR InterPro; IPR036122; CaM-bd_dom_sf.
DR InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR10153:SF41; INTERMEDIATE CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 4; 1.
DR PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02888; CaMBD; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR SMART; SM01053; CaMBD; 1.
DR SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 25..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 271..344
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000259|SMART:SM01053"
SQ SEQUENCE 394 AA; 43450 MW; 128B41A0F3916559 CRC64;
MGGDLVLGLG ALRLRKRLLE QEKSLAGWAL VLAGTGIGLM VLHAEMLWFG GCSLFMTDNG
LRDWRGADRA AGGADRAGAG GVRAAPGRPC GPAALQDLGA SLTSPQPWPG FLGQGEALLS
LAMLLRLYLV PRAVLLRSGV LLNASYRSIG ALNQVRFRHW FVAKLYMNTH PGRLLLGLTL
GLWLTTAWVL SVAERQAVNA TGHLSDTLWL IPITFLTIGY GDVVPGTMWG KIVCLCTGVM
GVCCTALLVA VVARKLEFNK AEKHVHNFMM DIQYTKEMKE SAARVLQEAW MFYKHTRRKE
SRAARRHQRR LLAAINAFRQ VRLKHRKLQE QVNSMVDISK MHMILYDLQQ NLSSSHRALE
KQIDTLAGKL DALTELLSTA LGPRQLPEPS QQST
//
