ID A0A2K5WMM0_MACFA Unreviewed; 413 AA.
AC A0A2K5WMM0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Melanocyte inducing transcription factor {ECO:0000313|Ensembl:ENSMFAP00000038409.2};
GN Name=MITF {ECO:0000313|Ensembl:ENSMFAP00000038409.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000038409.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000038409.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000038409.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MiT/TFE family.
CC {ECO:0000256|ARBA:ARBA00008289}.
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DR AlphaFoldDB; A0A2K5WMM0; -.
DR SMR; A0A2K5WMM0; -.
DR Ensembl; ENSMFAT00000012664.2; ENSMFAP00000038409.2; ENSMFAG00000038478.2.
DR VEuPathDB; HostDB:ENSMFAG00000038478; -.
DR GeneTree; ENSGT00940000156326; -.
DR Proteomes; UP000233100; Chromosome 2.
DR Bgee; ENSMFAG00000038478; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd18926; bHLHzip_MITF; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR021802; MiT/TFE_C.
DR InterPro; IPR031867; MiT/TFE_N.
DR PANTHER; PTHR45776:SF4; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR45776; MIP04163P; 1.
DR Pfam; PF11851; DUF3371; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF15951; MITF_TFEB_C_3_N; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 198..251
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 383..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 244..285
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 383..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 413 AA; 46275 MW; D1A2004770F24258 CRC64;
MLEMLEYNHY QVQTHLENPT KYHIQQAQRQ QVKQYLSTTL ANKHANQVLS LPCPNQPGDH
VMPPVPGSSA PNSPMAMLTL NSNCEKEGFY KFEEQNRAES ECPGMNTHSR ASCMQMDDVI
DDIISLESSY NEEILGLMDP ALQMANTLPV SGNLIDLYGN QGLPPPGLTI SNSCPANLPN
IKRELTESEA RALAKERQKK DNHNLIERRR RFNINDRIKE LGTLIPKSND PDMRWNKGTI
LKASVDYIRK LQREQQRAKE LENRQKKLEH ANRHLLLRIQ ELEMQARAHG LSLIPSTGLC
SPDLVNRIIK QEPVLENCSQ DLLQHHADLT CTTTLDLTDG TITFNNNLGT GTEANQAYSV
PTKMGSKLED ILMDDTLSPV GVTDPLLSSV SPGASKTSSR RSSMSMEETE HAC
//
