ID A0A2K5WNM4_MACFA Unreviewed; 3113 AA.
AC A0A2K5WNM4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 02-DEC-2020, entry version 15.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSMFAP00000038721};
GN Name=CENPF {ECO:0000313|Ensembl:ENSMFAP00000038721};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000038721, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000038721, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000038721}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (FEB-2018) to UniProtKB.
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DR EMBL; AQIA01001639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01001640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01001641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01001642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005540891.1; XM_005540834.2.
DR RefSeq; XP_015305505.1; XM_015450019.1.
DR Ensembl; ENSMFAT00000012972; ENSMFAP00000038715; ENSMFAG00000038702.
DR Ensembl; ENSMFAT00000012978; ENSMFAP00000038721; ENSMFAG00000038702.
DR GeneID; 102144197; -.
DR KEGG; mcf:102144197; -.
DR CTD; 1063; -.
DR GeneTree; ENSGT00730000111187; -.
DR OMA; YNAQLVQ; -.
DR OrthoDB; 205405at2759; -.
DR Proteomes; UP000233100; Chromosome 1.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874; PTHR18874; 2.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 3.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 1..307
FT /note="CENP-F_N"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1892..2034
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2130..2269
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2312..2451
FT /note="CENP-F_leu_zip"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2968..3012
FT /note="CENP-F_C_Rb_bdg"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 208..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1719..1745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2888..2976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3022..3113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 280..377
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 386..413
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 418..501
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 505..615
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 623..650
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 658..685
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 725..745
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 832..873
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 899..996
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1029..1109
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1118..1159
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1203..1244
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1286..1313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1397..1417
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1548..1611
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1623..1645
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1761..1781
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1789..1816
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1824..1844
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1910..1930
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1945..1996
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2001..2077
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2106..2133
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2141..2277
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2292..2315
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2323..2459
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2474..2543
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2561..2602
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2617..2683
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2688..2715
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2738..2772
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2780..2824
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2835..2862
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2927..2955
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3028..3079
FT /note="Polar"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3081..3098
FT /note="Polyampholyte"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3113 AA; 357577 MW; 7B180E9BD57F122A CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKEKQQRQFQ LDSLEAALQK QKQKVENEKT
EGTNLKRENQ RLMEICESLE KTKQKISHEL QVKESQVNFQ EGQLNSGKKQ IEKLEQELKR
CKSELERSQQ AAQSADVSLN PCNTPQKIFT TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
LEAEVKALQA KKASQTLPQT TMNHRDIARH QASSSVFSWQ QEKTPSHLSS NSQKTPIRRD
FCASYFSGEQ EVTPSRSTLQ IGKRDANSSF FDNSSSPHLL EQLKVQNQEL RSKINELELR
LQGQEKEMKG QVNKFQELQL QLEKAKVELI EKEKVLNKCR DELVRTTAQY DQASTKCTAL
EQKLRKLSED LSCQRQNAES ARCSLEQKIK EKEKEFQEEL SRQQRSFQTL DQECIQVKAR
LTQELQQAKN MHNVLQAELD KVTAVKQQLE KNLEEFKQKL CRAEQASQAS QIKEDELRRS
VEEMKKENNL LKSQSEQKAR EVCHLEAELK NVKQYLNQSQ NFAEEMKVKN TSQETMLRDL
QEKINQQENS LTLEKLKLAV AELEKQRDCS QDLLKKREHH IEQLNDKLSK TEKESKALLS
ALELKKKEYE ELKEEKTLFS CWKSENEKLL TQMESEKENL QSKINHLETC LKTQQIKSHE
YNERVRTLEM DRENLSVEIR NLHNVIDSKS VEVETQKLAY VELQQKAEFS DQKHQKEIEN
MCLKTSQLTG QVEDLEHKLQ LLSNEIMDKD RCYQDLHAEY ESLRDLLKSK DASLVTNEDH
QRSLLAFVEQ PAMHNSFANI IEEQGSMLSE RSECHLEADQ SPKNSAILQN RVDSLEFSLE
SQKQMNSDLQ KQCEELVQMK GEIEENLMKA EQMHQSFVAE TSQRISKLQE DTSAHQNVVA
ETLSALENKE KELQLLNDKL ATEQAEIQEL KQSNHLLEDS LKELQLLSET LSLEKKEMSS
IISLNKREIE ELTQENETLK EINASLNQEK MNLIQKSESF ANYIDEREKS ISELSDQYKQ
ENLILLQRCE ETGNAYEDLS QKYKAAQEKN SKLECLLNEC TSLCENRKNE LEQLKEAFAK
EHQEFLTKLA FAEERNQNLM LELETVQQDL RSEMTDTRNN SKSETDGLKQ EIMTLKEEQN
KMQKEVNDLL QENEQLMKVM KTKHECQNLE SEPIRNCVKE RESERNQCNF KPQMDLEVKE
ISLDSYNVQL VQLEAMLRNM ELKLQESEKE KECLQHELQI IRGDLETRNL QDMQSQEISG
LKDCEVDAEE RYISVLHGLS TSQNDNAHLE CSLQTAMNKL NELEKICEIL QAEKCELVTE
LNDSRSECIT ATRKMAEEVG KLVNEVKILN DDSGLLHGEL VEDIPGGELG EQANEQHPMC
LAPLDESNSY EHLTLSNKEV QMHFAELQEK FSSLQSEHKI LHDQHCQMSS KMSELQTYID
SLKAENLVLS TNLRNFQGDL VKEMQPGLEE GLVPSLSSCV PDSPSLSSLG DSSFYKALLE
QTGEMSLLNN LEGTVSANQC SVDEVFCSSL LEENLTKKEM PSAPAKGVEE LESLCEAYRQ
SLEKLEEKME SQGIMKNKEI QELQQLLSSE RQELDCLRKQ YLSENEQWQQ KLTSVTLEME
SKLAAEKKQT EQLSLELEVA RLQLQGLDLS SRSLLGIDTE DAIQGRNESC DISKEHTSET
TERTPKHDVH QICDKDVQQD LRLDIEKITE TGAVKLTGEC SGEQSQDTNC KTPGEDKSQG
SSECISELSF SGANASVPMD ILGNQENIQN LQLRVKETSN ENLRLLHVIE ERDRKVENLL
NEMKELDSKL HLQEVQLMTK IEACIELEKL VGELKKENSD LSEKLEYFSC DNQELLQRVE
SSEGLNSNLE MHADKSSHED IEDNVAKVND SWKERFLDVE NELSSIRSEK ANIEHQALSL
EADLEIVQTE KLCLEKDNEN NQKVIVCLEE ELSVVTSERN QLRGELDTMS KKIMELDQLS
EKMKEKTQEL ESHRSEYLHC IQVAEAKVKE KTELLQTLSS DVSELLKDKT HLQEKLQSLE
KDSQALSLTK CELENQIAQL NKEKELLVKE SESLQARLNE SDYEKLNVSK ALEAALVEKG
EFALRLSSTQ EEVHQLRRGI EKLRVRIEAD ERKQLHVAEK LKERERENDS LKDKVENLER
ELQMSEENQE LVILDAENSK AEVETLKTQI EEMARSLKVF ELDLVTLRSE KENLTKQIQD
KQGQVSELDK LLSSVKSLLE EKEQAEIQIK EESKTAVEML QNQLKELNEA VAALCGDQET
MKATEQSLDP SVEEAHQLRN SIEKLRARLE TDEKKQLCVL EQLKESEHHA DLLKSRVENL
ERELEIAGKN QEHAALEAEN SKGEVETLKA KIEGMTQSLR DLELDLATVR SEKENLTNKL
QKEQERISEL EIINSSFENI LREKEQEKVQ MKEKSNTAME MLQTQLKELH ERVTALHNDQ
EACKAKEQNL SSQVDCLELE KAQLLQGLDE AKNNNIVLQS SVNGLIQEVE DGKQKLEKKD
EEISRLKNQI QDQEQLVSKL SQVEGEHQFW KKQNLELGNL TVELEQKIQV LQSKNTSLQD
TLEVLQSSYK NLENELELTK MDKISFVEKV NTMTAKETEL QREMHEMAQK TAELQEELSG
EKNRLTGELQ LLLEEIKSSK DQLKELTLEN SELKKSLDCM QKDQVEKEGK VREEIAEYQL
LLHEAEKKHQ ALLLDTNKQY EIEIHTYREK LTSKEECLSS QKLEMDLLKS SKEELNNSLK
ATTEALEELK KTKMDNLKYV NQLKKENERA QGKIKLLIKS CKQLEEEKEI LQKELSKLQA
AQEKQKTGTV MDIKVDELTT EIKELKEALE EKTKEADEYL DKYCSLLISH EKLEKAKEML
ETQVAHLCSQ QSKPDSRGSP LLDPVVPGPS PILSAAEKRL SSGQKKASGK RQRSSGIWEN
GRGPTPSTPE TFSKKSKKAV MSGIHPAEET EGTQFEPEGL PEVVKKGFAD IPTGKTSPYI
LRRTTMATRT SPRLAAQKLA LSPLSLGKEN LAESSKPTAG GSRSQKVKVA QQSPVDSDTI
LREPTTKSLL VNNLPERSPT DSPREGLRVK RGRLAPHPKV GLEPKGSENC KVQ
//
