ID A0A2K5WNM4_MACFA Unreviewed; 3113 AA.
AC A0A2K5WNM4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 18-JUN-2025, entry version 31.
DE SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSMFAP00000038721.2};
GN Name=CENPF {ECO:0000313|Ensembl:ENSMFAP00000038721.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000038721.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000038721.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000038721.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
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DR STRING; 9541.ENSMFAP00000038721; -.
DR Ensembl; ENSMFAT00000012978.2; ENSMFAP00000038721.2; ENSMFAG00000038702.2.
DR VEuPathDB; HostDB:ENSMFAG00000038702; -.
DR GeneTree; ENSGT00730000111187; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000038702; Expressed in bone marrow and 7 other cell types or tissues.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000940; C:outer kinetochore; IEA:Ensembl.
DR GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0051310; P:metaphase chromosome alignment; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR InterPro; IPR043513; Cenp-F.
DR InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR InterPro; IPR018463; Centromere_CenpF_N.
DR PANTHER; PTHR18874:SF10; CENTROMERE PROTEIN F; 1.
DR PANTHER; PTHR18874; CMF/LEK/CENP CELL DIVISION-RELATED; 1.
DR Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR Pfam; PF10473; CENP-F_leu_zip; 3.
DR Pfam; PF10481; CENP-F_N; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 1..307
FT /note="Centromere protein Cenp-F N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10481"
FT DOMAIN 1892..2034
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2130..2269
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2312..2451
FT /note="Centromere protein Cenp-F leucine-rich repeat-
FT containing"
FT /evidence="ECO:0000259|Pfam:PF10473"
FT DOMAIN 2968..3012
FT /note="Kinetochore protein Cenp-F/LEK1 Rb protein-binding"
FT /evidence="ECO:0000259|Pfam:PF10490"
FT REGION 208..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1719..1742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2888..3113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 13..131
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 280..685
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 832..873
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 899..996
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1029..1159
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1203..1244
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1286..1313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1548..1645
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1761..1844
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1910..2077
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 211..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1722..1731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3032..3056
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3078..3113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3113 AA; 357597 MW; FCF23E34A225EDC5 CRC64;
MSWALEEWKE GLPTRALQKI QELEGQLDKL KKEKQQRQFQ LDSLEAALQK QKQKVENEKT
EGTNLKRENQ RLMEICESLE KTKQKISHEL QVKESQVNFQ EGQLNSGKKQ IEKLEQELKR
CKSELERSQQ AAQSADVSLN PCNTPQKIFT TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
LEAEVKALQA KKASQTLPQT TMNHRDIARH QASSSVFSWQ QEKTPSHLSS NSQKTPIRRD
FCASYFSGEQ EVTPSRSTLQ IGKRDANSSF FDNSSSPHLL EQLKVQNQEL RSKINELELR
LQGQEKEMKG QVNKFQELQL QLEKAKVELI EKEKVLNKCR DELVRTTAQY DQASTKCTAL
EQKLKKLSED LSCQRQNAES ARCSLEQKIK EKEKEFQEEL SRQQRSFQTL DQECIQVKAR
LTQELQQAKN MHNVLQAELD KVTAVKQQLE KNLEEFKQKL CRAEQASQAS QIKEDELRRS
VEEMKKENNL LKSQSEQKAR EVCHLEAELK NVKQYLNQSQ NFAEEMKVKN TSQETMLRDL
QEKINQQENS LTLEKLKLAV AELEKQRDCS QDLLKKREHH IEQLNDKLSK TEKESKALLS
ALELKKKEYE ELKEEKTLFS CWKSENEKLL TQMESEKENL QSKINHLETC LKTQQIKSHE
YNERVRTLEM DRENLSVEIR NLHNVIDSKS VEVETQKLAY VELQQKAEFS DQKHQKEIEN
MCLKTSQLTG QVEDLEHKLQ LLSDEIMDKD RCYQDLHAEY ESLRDLLKSK DASLVTNEDH
QRSLLAFDEQ PAMHNSFANI IEEQGSMLSE RSECHLEADQ SPKNSAILQN RVDSLEFSLE
SQKQMNSDLQ KQCEELVQIK GEIEENLMKA EQMHQSFVAE TSQRISKLQE DTSAHQNVVA
ETLSALENKE KELQLLNDKL ATEQAEIQEL KQSNHLLEDS LKELQLLSET LSLEKKEMSS
IISLNKREIE ELTQENETLK EINASLNQEK MNLIQKSESF ANYIDEREKS ISELSDQYKQ
ENLILLQRCE ETGNAYEDLS QKYKAAQEKN SKLECLLNEC TSLCENRKNE LEQLKEAFAK
EHQEFLTKLA FAEERNQNLM LELETVQQDL RSEMTDTRNN SKSETDGLKQ EIMTLKEEQN
KMQKEVNDLL QENEQLMKVM KTKHECQNLE SEPIRNCVKE RESERNQCNF KPQMDLEVKE
ISLDSYNVQL VQLEAMLRNM ELKLQESEKE KECLQHELQI IRGDLETRNL QDMQSQEISG
LKDCEVDAEE RYISVLHGLS TSQNDNEHLE CSLQTAMNKL NELEKICEIL QAEKCELVTE
LNDSRSECIT ATRKMAEEVG KLVNEVKILN DDSGLLHGEL VEDIPGGELG EQANEQHPMC
LAPLDESNSY EHLTLSNKEV QMHFAELQEK FSSLQSEHKI LHDQHCQMSS KMSELQTYID
SLKAENLVLS TNLRNFQGDL VKEMQPGLEE GLVPSLSSCV PDSPSLSSLG DSSFYKALLE
QTGEMSLLNN LEGTVSANQC SVDEVFCSSL LEENLTKKEM PSAPAKGVEE LESLCEAYRQ
SLEKLEEKME SQGIMKNKEI QELQQLLSSE RQELDCLRKQ YLSENEQWQQ KLTSVTLEME
SKLAAEKKQT EQLSLELEVA RLQLQGLDLS SRSLLGIDTE DAIQGRNESC NISKEHTSET
TERTPKHDVH QICDKDVQQD LRLDIEKITE TGAVKLTGEC SGEQSQDTNC KTPGEDKSQG
SSECISELSF SGANASVPMD ILGNQENIQN LQLRVKETSN ENLRLLHVIE ERDRKVENLL
NEMKELDSKL HLQEVQLMTK IEACIELEKL VGELKKENSD LSEKLEYFSC DNQELLQRVE
SSEGLNSNLE MHADKSSHED IEDNVAKVND SWKERFLDVE NELSSIRSEK ANIEHQALSL
EADLEIVQTE KLCLEKDNEN NQKVIVCLEE ELSVVTSERN QLRGELDTMS KKIMELDQLS
EKMKEKTQEL ESHRSEYLHC IQVAEAKVKE KTELLQTLSS DVSELLKDKT HLQEKLQSLE
KDSQALSLTK CELENQIAQL NKEKELLVKE SESLQARLNE SDYEKLNVSK ALEAALVEKG
EFALRLSSTQ EEVHQLRRGI EKLRVRIEAD ERKQLHVAEK LKERERENDS LKDKVENLER
ELQMSEENQE LVILDAENSK AEVETLKTQI EEMARSLKVF ELDLVTLRSE KENLTKQIQD
KQGQVSELDK LLSSVKSLLE EKEQAEIQIK EESKTAVEML QNQLKELNEA VAALCGDQET
MKATEQSLDP SVEEAHQLRN SIEKLRARLE TDEKKQLCVL EQLKESEHHA DLLKSRVENL
ERELEIAGKN QEHAALEAEN SKGEVETLKA KIEGMTQSLR DLELDLATVR SEKENLTNKL
QKEQERISEL EIINSSFENI LREKEQEKVQ MKEKSNTAME MLQTQLKELH ERVTALHNDQ
EACKAKEQNL SSQVDCLELE KAQLLQGLDE AKNNNIVLQS SVNGLIQEVE DGKQKLEKKD
EEISRLKNQI QDQEQLVSKL SQVEGEHQFW KKQNLELGNL TVELEQKIQV LQSKNTSLQD
TLEVLQSSYK NLENELELTK MDKISFVEKV NTMTAKETEL QREMHEMAQK TVELQEELSG
EKNRLTGELQ LLLEEIKSSK DQLKELTLEN SELKKSLDCM QKDQVEKEGK VREEIAEYQL
LLHEAEKKHQ ALLLDTNKQY EIEIHTYREK LTSKEECLTS QKLEMDLLKS SKEELNNSLK
ATTEALEELK KTKMDNLKYV NQLKKENERA QGKIKLLIKS CKQLEEEKEI LQKELSKLQA
AQEKQKTGTV MDIKVDELTT EIKELKEALE EKTKEADEYL DKYCSLLISH EKLEKAKEML
ETQVAHLCSQ QSKPDSRGSP LLDPVVPGPS PILSAAEKRL SSGQKKASGK RQRSSGIWEN
GRGPTPSTPE TFSKKSKKAV MSGIHPAEET EGTQFEPEGL PEVAKKGFAD IPTGKTSPYI
LRRTTMATRT SPRLAAQKLA LSPLSLGKEN LAESSKPTAG GSRSQKVKVA QQSPVDSDTI
LREPTTKSLL VNNLPERSPT DSPREGLRVK RGRLAPDPKV GLEPKGSENC KVQ
//
