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Database: UniProt
Entry: A0A2K5WNM4_MACFA
LinkDB: A0A2K5WNM4_MACFA
Original site: A0A2K5WNM4_MACFA 
ID   A0A2K5WNM4_MACFA        Unreviewed;      3113 AA.
AC   A0A2K5WNM4;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   02-DEC-2020, entry version 15.
DE   SubName: Full=Centromere protein F {ECO:0000313|Ensembl:ENSMFAP00000038721};
GN   Name=CENPF {ECO:0000313|Ensembl:ENSMFAP00000038721};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000038721, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000038721, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000038721}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
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DR   EMBL; AQIA01001639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIA01001640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIA01001641; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIA01001642; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005540891.1; XM_005540834.2.
DR   RefSeq; XP_015305505.1; XM_015450019.1.
DR   Ensembl; ENSMFAT00000012972; ENSMFAP00000038715; ENSMFAG00000038702.
DR   Ensembl; ENSMFAT00000012978; ENSMFAP00000038721; ENSMFAG00000038702.
DR   GeneID; 102144197; -.
DR   KEGG; mcf:102144197; -.
DR   CTD; 1063; -.
DR   GeneTree; ENSGT00730000111187; -.
DR   OMA; YNAQLVQ; -.
DR   OrthoDB; 205405at2759; -.
DR   Proteomes; UP000233100; Chromosome 1.
DR   GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR   GO; GO:0097539; C:ciliary transition fiber; IEA:Ensembl.
DR   GO; GO:0000940; C:condensed chromosome outer kinetochore; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0005635; C:nuclear envelope; IEA:Ensembl.
DR   GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0045120; C:pronucleus; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR   GO; GO:0070840; F:dynein complex binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0051310; P:metaphase plate congression; IEA:Ensembl.
DR   GO; GO:0000278; P:mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0015031; P:protein transport; IEA:Ensembl.
DR   GO; GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR   GO; GO:0016202; P:regulation of striated muscle tissue development; IEA:Ensembl.
DR   GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR   InterPro; IPR043513; Cenp-F.
DR   InterPro; IPR018302; CenpF/LEK1_Rb-prot-bd.
DR   InterPro; IPR019513; Centromere_CenpF_leu-rich_rpt.
DR   InterPro; IPR018463; Centromere_CenpF_N.
DR   PANTHER; PTHR18874; PTHR18874; 2.
DR   Pfam; PF10490; CENP-F_C_Rb_bdg; 1.
DR   Pfam; PF10473; CENP-F_leu_zip; 3.
DR   Pfam; PF10481; CENP-F_N; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT   DOMAIN          1..307
FT                   /note="CENP-F_N"
FT                   /evidence="ECO:0000259|Pfam:PF10481"
FT   DOMAIN          1892..2034
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2130..2269
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2312..2451
FT                   /note="CENP-F_leu_zip"
FT                   /evidence="ECO:0000259|Pfam:PF10473"
FT   DOMAIN          2968..3012
FT                   /note="CENP-F_C_Rb_bdg"
FT                   /evidence="ECO:0000259|Pfam:PF10490"
FT   REGION          208..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1719..1745
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2888..2976
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3022..3113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          13..131
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          164..191
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          280..377
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          386..413
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          418..501
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          505..615
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          623..650
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          658..685
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          725..745
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          832..873
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          899..996
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1029..1109
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1118..1159
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1203..1244
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1286..1313
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1397..1417
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1548..1611
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1623..1645
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1761..1781
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1789..1816
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1824..1844
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1910..1930
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1945..1996
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2001..2077
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2106..2133
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2141..2277
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2292..2315
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2323..2459
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2474..2543
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2561..2602
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2617..2683
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2688..2715
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2738..2772
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2780..2824
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          2835..2862
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        2927..2955
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3028..3079
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3081..3098
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3113 AA;  357577 MW;  7B180E9BD57F122A CRC64;
     MSWALEEWKE GLPTRALQKI QELEGQLDKL KKEKQQRQFQ LDSLEAALQK QKQKVENEKT
     EGTNLKRENQ RLMEICESLE KTKQKISHEL QVKESQVNFQ EGQLNSGKKQ IEKLEQELKR
     CKSELERSQQ AAQSADVSLN PCNTPQKIFT TPLTPSQYYS GSKYEDLKEK YNKEVEERKR
     LEAEVKALQA KKASQTLPQT TMNHRDIARH QASSSVFSWQ QEKTPSHLSS NSQKTPIRRD
     FCASYFSGEQ EVTPSRSTLQ IGKRDANSSF FDNSSSPHLL EQLKVQNQEL RSKINELELR
     LQGQEKEMKG QVNKFQELQL QLEKAKVELI EKEKVLNKCR DELVRTTAQY DQASTKCTAL
     EQKLRKLSED LSCQRQNAES ARCSLEQKIK EKEKEFQEEL SRQQRSFQTL DQECIQVKAR
     LTQELQQAKN MHNVLQAELD KVTAVKQQLE KNLEEFKQKL CRAEQASQAS QIKEDELRRS
     VEEMKKENNL LKSQSEQKAR EVCHLEAELK NVKQYLNQSQ NFAEEMKVKN TSQETMLRDL
     QEKINQQENS LTLEKLKLAV AELEKQRDCS QDLLKKREHH IEQLNDKLSK TEKESKALLS
     ALELKKKEYE ELKEEKTLFS CWKSENEKLL TQMESEKENL QSKINHLETC LKTQQIKSHE
     YNERVRTLEM DRENLSVEIR NLHNVIDSKS VEVETQKLAY VELQQKAEFS DQKHQKEIEN
     MCLKTSQLTG QVEDLEHKLQ LLSNEIMDKD RCYQDLHAEY ESLRDLLKSK DASLVTNEDH
     QRSLLAFVEQ PAMHNSFANI IEEQGSMLSE RSECHLEADQ SPKNSAILQN RVDSLEFSLE
     SQKQMNSDLQ KQCEELVQMK GEIEENLMKA EQMHQSFVAE TSQRISKLQE DTSAHQNVVA
     ETLSALENKE KELQLLNDKL ATEQAEIQEL KQSNHLLEDS LKELQLLSET LSLEKKEMSS
     IISLNKREIE ELTQENETLK EINASLNQEK MNLIQKSESF ANYIDEREKS ISELSDQYKQ
     ENLILLQRCE ETGNAYEDLS QKYKAAQEKN SKLECLLNEC TSLCENRKNE LEQLKEAFAK
     EHQEFLTKLA FAEERNQNLM LELETVQQDL RSEMTDTRNN SKSETDGLKQ EIMTLKEEQN
     KMQKEVNDLL QENEQLMKVM KTKHECQNLE SEPIRNCVKE RESERNQCNF KPQMDLEVKE
     ISLDSYNVQL VQLEAMLRNM ELKLQESEKE KECLQHELQI IRGDLETRNL QDMQSQEISG
     LKDCEVDAEE RYISVLHGLS TSQNDNAHLE CSLQTAMNKL NELEKICEIL QAEKCELVTE
     LNDSRSECIT ATRKMAEEVG KLVNEVKILN DDSGLLHGEL VEDIPGGELG EQANEQHPMC
     LAPLDESNSY EHLTLSNKEV QMHFAELQEK FSSLQSEHKI LHDQHCQMSS KMSELQTYID
     SLKAENLVLS TNLRNFQGDL VKEMQPGLEE GLVPSLSSCV PDSPSLSSLG DSSFYKALLE
     QTGEMSLLNN LEGTVSANQC SVDEVFCSSL LEENLTKKEM PSAPAKGVEE LESLCEAYRQ
     SLEKLEEKME SQGIMKNKEI QELQQLLSSE RQELDCLRKQ YLSENEQWQQ KLTSVTLEME
     SKLAAEKKQT EQLSLELEVA RLQLQGLDLS SRSLLGIDTE DAIQGRNESC DISKEHTSET
     TERTPKHDVH QICDKDVQQD LRLDIEKITE TGAVKLTGEC SGEQSQDTNC KTPGEDKSQG
     SSECISELSF SGANASVPMD ILGNQENIQN LQLRVKETSN ENLRLLHVIE ERDRKVENLL
     NEMKELDSKL HLQEVQLMTK IEACIELEKL VGELKKENSD LSEKLEYFSC DNQELLQRVE
     SSEGLNSNLE MHADKSSHED IEDNVAKVND SWKERFLDVE NELSSIRSEK ANIEHQALSL
     EADLEIVQTE KLCLEKDNEN NQKVIVCLEE ELSVVTSERN QLRGELDTMS KKIMELDQLS
     EKMKEKTQEL ESHRSEYLHC IQVAEAKVKE KTELLQTLSS DVSELLKDKT HLQEKLQSLE
     KDSQALSLTK CELENQIAQL NKEKELLVKE SESLQARLNE SDYEKLNVSK ALEAALVEKG
     EFALRLSSTQ EEVHQLRRGI EKLRVRIEAD ERKQLHVAEK LKERERENDS LKDKVENLER
     ELQMSEENQE LVILDAENSK AEVETLKTQI EEMARSLKVF ELDLVTLRSE KENLTKQIQD
     KQGQVSELDK LLSSVKSLLE EKEQAEIQIK EESKTAVEML QNQLKELNEA VAALCGDQET
     MKATEQSLDP SVEEAHQLRN SIEKLRARLE TDEKKQLCVL EQLKESEHHA DLLKSRVENL
     ERELEIAGKN QEHAALEAEN SKGEVETLKA KIEGMTQSLR DLELDLATVR SEKENLTNKL
     QKEQERISEL EIINSSFENI LREKEQEKVQ MKEKSNTAME MLQTQLKELH ERVTALHNDQ
     EACKAKEQNL SSQVDCLELE KAQLLQGLDE AKNNNIVLQS SVNGLIQEVE DGKQKLEKKD
     EEISRLKNQI QDQEQLVSKL SQVEGEHQFW KKQNLELGNL TVELEQKIQV LQSKNTSLQD
     TLEVLQSSYK NLENELELTK MDKISFVEKV NTMTAKETEL QREMHEMAQK TAELQEELSG
     EKNRLTGELQ LLLEEIKSSK DQLKELTLEN SELKKSLDCM QKDQVEKEGK VREEIAEYQL
     LLHEAEKKHQ ALLLDTNKQY EIEIHTYREK LTSKEECLSS QKLEMDLLKS SKEELNNSLK
     ATTEALEELK KTKMDNLKYV NQLKKENERA QGKIKLLIKS CKQLEEEKEI LQKELSKLQA
     AQEKQKTGTV MDIKVDELTT EIKELKEALE EKTKEADEYL DKYCSLLISH EKLEKAKEML
     ETQVAHLCSQ QSKPDSRGSP LLDPVVPGPS PILSAAEKRL SSGQKKASGK RQRSSGIWEN
     GRGPTPSTPE TFSKKSKKAV MSGIHPAEET EGTQFEPEGL PEVVKKGFAD IPTGKTSPYI
     LRRTTMATRT SPRLAAQKLA LSPLSLGKEN LAESSKPTAG GSRSQKVKVA QQSPVDSDTI
     LREPTTKSLL VNNLPERSPT DSPREGLRVK RGRLAPHPKV GLEPKGSENC KVQ
//
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