ID A0A2K5WQ63_MACFA Unreviewed; 498 AA.
AC A0A2K5WQ63;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=SPARC related modular calcium binding 1 {ECO:0000313|Ensembl:ENSMFAP00000039302.2};
GN Name=SMOC1 {ECO:0000313|Ensembl:ENSMFAP00000039302.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000039302.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000039302.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000039302.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR AlphaFoldDB; A0A2K5WQ63; -.
DR Ensembl; ENSMFAT00000013564.2; ENSMFAP00000039302.2; ENSMFAG00000036642.2.
DR VEuPathDB; HostDB:ENSMFAG00000036642; -.
DR GeneTree; ENSGT00390000018436; -.
DR Proteomes; UP000233100; Chromosome 7.
DR Bgee; ENSMFAG00000036642; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050840; F:extracellular matrix binding; IEA:InterPro.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0060173; P:limb development; IEA:Ensembl.
DR GO; GO:0045667; P:regulation of osteoblast differentiation; IEA:Ensembl.
DR CDD; cd16240; EFh_SPARC_SMOC1; 1.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00191; TY; 2.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 4.10.800.10; Thyroglobulin type-1; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR037639; SMOC1_EC.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR000716; Thyroglobulin_1.
DR InterPro; IPR036857; Thyroglobulin_1_sf.
DR PANTHER; PTHR12352; SECRETED MODULAR CALCIUM-BINDING PROTEIN; 1.
DR PANTHER; PTHR12352:SF13; SPARC-RELATED MODULAR CALCIUM-BINDING PROTEIN 1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR Pfam; PF16597; Thyroglob_assoc; 1.
DR Pfam; PF00086; Thyroglobulin_1; 2.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00211; TY; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF57610; Thyroglobulin type-1 domain; 2.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00484; THYROGLOBULIN_1_1; 2.
DR PROSITE; PS51162; THYROGLOBULIN_1_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00500}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 90..142
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 145..211
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DOMAIN 288..356
FT /note="Thyroglobulin type-1"
FT /evidence="ECO:0000259|PROSITE:PS51162"
FT DISULFID 182..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 191..211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
FT DISULFID 326..333
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00500"
SQ SEQUENCE 498 AA; 54978 MW; FFB8D4DB78000F8F CRC64;
MTVSSARSLC ESPPQDRCRL PAAARAPSEG RKAGALAEPA NPARCRLPSL AGTMLPARCA
RLLTPHLLLV LVQLSPARGH RTTGPRFLIS DRDPQCNLHC SRTQPKPICA SDGRSYESMC
EYQRAKCRDQ TLGVVHRGRC KDAGQSKCRL ERAQALEQAK KPQEAVFVPE CGEDGSFTQV
QCHTYTGYCW CVTPDGKPIS GSSVQNKTPV CSGSVTDKPL SQGNSGRKVS FRFFLTLNSD
DGSKPTPTME TQPVFDGDEI TAPTLWIKHL VIKDSKLNNT NIRNSEKVYS CDQERQSALE
EARQNPREGI VIPECAPGGL YKPVQCHQST GYCWCVLVDT GRPLPGTSTR YVMPSCESDA
RAKSTEVDDP FKDRELPGCP EGKKMEFITS LLDALTTDMV QAINSAAPTG GGRFSEPDPS
HTLEERVVHW YFSQLDSNSS NDINKREMKP FKRYVKKKAK PKKCARRFTD YCDLNKDKVI
SLPELKGCLG VSKEGRLV
//
