ID A0A2K5WTN5_MACFA Unreviewed; 3069 AA.
AC A0A2K5WTN5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Protein prune homolog 2 {ECO:0000256|ARBA:ARBA00039860};
DE AltName: Full=BNIP2 motif-containing molecule at the C-terminal region 1 {ECO:0000256|ARBA:ARBA00042084};
GN Name=PRUNE2 {ECO:0000313|Ensembl:ENSMFAP00000040565.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000040565.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000040565.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000040565.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PPase class C family. Prune subfamily.
CC {ECO:0000256|ARBA:ARBA00010331}.
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DR Ensembl; ENSMFAT00000014833.2; ENSMFAP00000040565.2; ENSMFAG00000046406.2.
DR VEuPathDB; HostDB:ENSMFAG00000046406; -.
DR GeneTree; ENSGT00940000154422; -.
DR Proteomes; UP000233100; Chromosome 15.
DR Bgee; ENSMFAG00000046406; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016462; F:pyrophosphatase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 3.10.310.20; DHHA2 domain; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR InterPro; IPR022181; Bcl2-/adenovirus-E1B.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR004097; DHHA2.
DR InterPro; IPR038222; DHHA2_dom_sf.
DR PANTHER; PTHR12112; BNIP - RELATED; 1.
DR PANTHER; PTHR12112:SF11; PROTEIN PRUNE HOMOLOG 2; 1.
DR Pfam; PF12496; BNIP2; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF02833; DHHA2; 1.
DR SMART; SM01131; DHHA2; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 2889..3050
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT REGION 433..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 675..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..1083
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1236..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1389..1454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1472..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1506..1594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1628..1704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1738..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1783..1814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2081..2113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2158..2215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2237..2262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2479..2539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2582..2627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2683..2703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2772..2791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2808..2827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2835..2869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..628
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 681..696
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..1004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1005..1028
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1069..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1236..1257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1433..1451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1506..1587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1629..1668
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1676..1691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1746..1770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2092..2107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2158..2206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2237..2260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2507..2539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2847..2861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3069 AA; 338161 MW; 733273980E9F8450 CRC64;
MEEFLQRAKS KLNRSKRLEK VHVVIGPKSC DLDSLISTFT YAYFLDKVSP PGVLCLPVLN
IPRTEFNYFT ETRFILEELN ISESFHIFRD EINLHQLNDE GKLLVTLVGG NVLASEDKTL
ESAVVKVINP VEQSDANVEF RESSSSLVLK EILQEAPELI TEQLAHRLRG SILFKWMTME
SEKISEKQEE ILSVLEEKFP NLPPREDIIN VLQETQFSAQ GLSIEQTMLK DLKELSDGEI
KVAISTVSMN LENCLFHSNI TSDLKAFTDK FGFDVLILFA SYLSEEQQPR RQIAVYSENV
ELCSQICCEL EECQNPCLEL EPFDCGCDEI LVYQQEDPSV TCDQVVLVVK EVINRRCPEM
VSNSRTSSTE AVAGSAPLSQ GSSGIMELYG SDVEPQPSSV NFIENPPDLN DSNQAQVDAN
VDLVSPDSGL ATIRSSRSSK ESSVFLSDDS PVGEGAGPHH TLLPGLDSYS PIPEGAVAEE
HAWSGEHGEH FDLFNFDPAP MASGQSQQSS HSADYSPADD FFPNSDLSEG QLPAGPEGLD
GMGTNMSNYS STSLLSGAGK DSLVEYDEEF VQRQESPRDN SERNLSLTDF VGDESPSPDR
LKNIGKRIPP TPMNSLVESS PSTEEPASLY TEDMTQKATD TGHMGPPQTH ARCSSWWGGL
EIDSKNIADA WSSSERESVF QSPESWKEHK PSSIDRRASD SVFQPKSLEF TKSGPWESEF
GQPELGSNDI QDQNEESLSF QNVPMEKPPL PNTSPQGTNH LIEDFASLWH SGRSPTAMPE
PWGNPTDDGE PAAAAPFPAW SAFGKEDHAE ALKNTWNLHP TSGETPSVRD PNEWAMAKGG
FVFSSSELLD NSPSEINNEA APEIWGKRNN DSRDHIFAPG NASSDLDHTW TNSKPPKEDQ
NGLVDPKTRG KVYEKVDSWN LFEESMKKGG SDVLAPWEDS FLSYKCSDYS ASNLGEDSVP
SPLDTNYSTS DSYTSPTCAG DEKETEHKPF AKEEGFESKD GNSTAEETDI PPQSLQQPSR
NRISSGPGNL DMWASPHTDN SSEINATHDP DENELKTEHT DGKNVSMEED VGESSQSSYD
DPSMMQLYNE TNRQLTLLHS STNSRQTAPD SLDLWNRVIL EDTQSTATIS DMDNDLDWDD
CSGGVALPSD GQTEGYMAES TEPETRFTVR QLEPWGLEYQ EANQVDWELP ASDEHTKDSA
PSGHHTLNEK SGQLIANSIW DSVMRDKDMS SFMLPGSSYL TDSEQSELPS EIPSHSANVK
DTHCPDAPAA SGTSESGVLV SHLDNQETER ETLQSDAASL ATRLENPGHF AHPDPWKGRS
NGQSESEKEA QGATNREHLD EEEVIASGVE SASGISEKGQ SDRELSSLVA SEHQDICVKS
GKISSLAVTF SPQTEEPEEV SECEKGSHNL DSRDVQTGMS ADNLRPKDTY EQHLMSQRNS
GETTETSDGM NFPKYVSVPE KNLEKTEECN ILEPENVGGR GPHKVPRSLD FGDAPVDSVV
HVSCTSSKIT ENLDVKGTEN SLPGASSSGN FDRDTISSEY THSSASSPEL NDSSVALSSW
GQQPSSGYQE ENRGNWSEQN HQESELITTD GPVEIVTKMK DLEKNRTNEF EKSLDRKTPT
FLEIWNDSID GDSLSSLSSP ETGRYSEHSG TRQESNLIAS YQEKNEHDIS ATVQPEDARA
ISTSSGSDDD SVGGEESVEE EIQAANCHVA QDESRAWESL NESNKFLVTA DPKSENIYDY
LGSSEPAENE SKSNPFCDNQ QSSPDHWNFS PLTETEIQIP AVEKEMRSSP ETGKTGDVAW
QISPKAEPKN EDNSQLEMLG FSADSTEWWN ASPQEGRLIE STFERELSDP SDVLEINSSV
YQNASPWGVP VQNDVEPVET HYANPFSDNH QSPFLEGNGK NSHEQLWNIQ PRQPDPDADK
FSQLVILDQI KEKDSREQTF VSAAGDELTP ETPTQERHRD AMLSVCDQPD AGFTHAEENG
CVTSNVSTNE GQETNQWEQE KSYLGEMTHS SIATENFPAV SSPTQLIMKP GSEWDGSAPN
EDSQGTFVPD ILHGNFQEGG QLASAAPDLW VDAKKPISLK ADGENPDILT HCDHDSNSQA
SNSPDICHDS EAKQDTEKHL GACMGPEVES SELCLTEPEM DKEPIHEPGQ EFVPSNAELD
SENATPLPPI GNQADIKGSS QPASHKGSPE PSEINSDDNT DLQASEKGAS PDMAPILEPV
DRRIPRIENV ATSIFVTHQE PTPEGDSSWL SDSFSPESQS GARALFDGEP RLSTENPAMV
PDALLSSDTC LDISEAAFDH SFSDASGLNT STGTIDDMSK LTLSEGHPET PVDGDLAKQD
ICSSEASWGD FEYDVMGQNI DEDLLREPEH FLYGGDPPLE EDSLKQSLAP YTPPFDLSYL
TEPAQSAETI EEAGSPEDES LGYRAAEIVL SALPDRRSEV NQAETKNRLP GSQLAVLHIH
EDPESVYLPV GAGANILSPS STDWEVETDN SDLPAGGDIG PPNGDSKEIS ELEEEKVIPT
KEPEQIKSEY KEGRCTEKNE DRHVLHMDYI LVNHEENLHS KPEAREERES IAELELYVGS
KETGPQGTQL ASFPDTCQPA SLNETKGISA EKMSSKGDTR SSFESPAQDQ SWMFLGHSEV
GDLSSGPGWS GKTVEPFSEL SLGEGPQLQI LQEMKPLESL ALEEASGPVS QSQKSKSRGR
ADPDAVMLQA VTHDNEWEML SPQPAQKTMI RDTEMEEETE FLELGTRKPR PHGLLSEDVG
MDIPFEEGVL SPSAADMRPE PPNSLDLNGT HPRRIKLTAP NINLSLDQSE GSILSDDNLD
SPDEIDINVD ELDTPDEADS FEYTGHDPTA NKDSGQESES IPEYTAEEER EDNRLWRTVV
IGEQEQRIDM KVIEPYRRVI SHGGYYGDGL NAIIVFAACF LPDSGRADYH YVMENLFLYV
ISTLELMVAE DYMIVYLNGA TPRRKMPGLG WMKKCYQMID RRLRKNLKSF IIVHPSWFIR
TILAVTRPFI SSKFSSKIKY VNSLSELSGL IPMDCIHIPE SIIKTSCLYN DPEMSSMEKD
IDLKLKEKP
//
