ID A0A2K5WVN0_MACFA Unreviewed; 1709 AA.
AC A0A2K5WVN0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Sialic acid binding Ig like lectin 1 {ECO:0000313|Ensembl:ENSMFAP00000041268.2};
GN Name=SIGLEC1 {ECO:0000313|Ensembl:ENSMFAP00000041268.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000041268.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000041268.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000041268.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR STRING; 9541.ENSMFAP00000041268; -.
DR Ensembl; ENSMFAT00000015544.2; ENSMFAP00000041268.2; ENSMFAG00000041387.2.
DR VEuPathDB; HostDB:ENSMFAG00000041387; -.
DR GeneTree; ENSGT01100000263535; -.
DR OrthoDB; 5360480at2759; -.
DR Proteomes; UP000233100; Chromosome 10.
DR Bgee; ENSMFAG00000041387; Expressed in spleen and 3 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032480; P:negative regulation of type I interferon production; IEA:Ensembl.
DR CDD; cd00096; Ig; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 17.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR47243; SIALOADHESIN; 1.
DR PANTHER; PTHR47243:SF1; SIALOADHESIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 6.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 17.
DR SMART; SM00408; IGc2; 14.
DR SUPFAM; SSF48726; Immunoglobulin; 14.
DR PROSITE; PS50835; IG_LIKE; 14.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1709
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030052404"
FT TRANSMEM 1642..1665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 139..233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 238..320
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 326..405
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 411..507
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 511..593
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 708..785
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 799..888
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 898..977
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 984..1083
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1085..1165
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1172..1257
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1259..1341
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1445..1528
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1536..1629
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 1709 AA; 182841 MW; 275F0D4CA33238E1 CRC64;
MGFLPELLLL ASFFPPGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITTIWY
YDYSGRRQVA SHSADPKLVE AHFRGRAEFV GNPEHKVCNL LLKDLQPEDS GSYNFRFEIS
EGNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYACLQEQ VRLQWQGQDP
ARSVTFSSQK FEPTGVSQLE TLHMAMSWQD HGRILRCQLS VASHRAHSEI HLQVKYAPKG
VKILLSPSGR NILPGEPVTL TCQVNSSYPA VSSIKWLKDG VHLQTKTGVL HLPQAAWSDA
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLHYSW
YKNHVPLEDA HSHILRLHSV TRADTGFYFC EVQNAHGSER SGPVGMLVNH PPLTPVLTAF
LETQAGLVGI LHCSVVSEPL ATLVLSHRGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD
LEEADSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD
ARFSWYLNGA LLHEGPSSSL LLPAASSTDA GSYHCWARDG HSASGPSSPA ILTVLYPPRQ
PTFTTRLDLD AAGAGAGRQG LLLCRVDSDP PARLQLLHKD HVVATSLPSG GGCSTCGGCS
PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNASA SATFNGQSTV LVIAPSHTLQ
EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA
GAQLSTPVLL SVLYPPDPPK LSALLDIGQG HMAVFVCTVD SRPLARLALF HGEHLLATSL
GPQVPFRGRL QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSANTSLF FQVRGAWVQV
SPSPELQEGQ AVVLSCQVPT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC
QAQAPGSATT SLAAPVSLHV SYAPRQVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLYG
DRLVASTLQG VGGPESSSPR LQAAVAPNTL RLEIHGAMLE DEGVYTCEAS NTLGQASASA
DFDAQAVNVQ VWPGTTVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD GRSIPLPNVT
VRDATSYRCG VGPPGQAPRL SRPITLDVLY APRNLRLTYL LESRGGQMAL VLCTVDSRPP
AQLALSHAGR LLASSTAASI PNTLRLELRE PQPSDEGFYS CSARSPLGQA NTSLELRLEG
VRVILAPEAT VPEGAPITVT CEDPAARPPT LYAWYHNGRW LQEGPAASLS FPVATRAHAG
AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS
HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQEVPAGD DTYVCTAQNL LGSISTIGRL
QVEGARVVAE PGLYVPEGAA LNLSCRLLGG PGPMGNSTFA WFWNDQRLHV DPVPTLAFTH
VARAQAGMYH CLAELPTGAA ASTPVMLHVL YPPKTPTMMV FVEPENGLRG ILDCRVDSEP
LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDF EALRPSDQGE YVCSASNALG
SASTSTYFGV RALHRLHQFQ QLLWVLGVLV GLLLLLLGLG AYYTWRRRRV YKQSMGENSV
EMTFQKETTQ LIDPDAATCE TSSCAPPLG
//
