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Database: UniProt
Entry: A0A2K5WX31_MACFA
LinkDB: A0A2K5WX31_MACFA
Original site: A0A2K5WX31_MACFA 
ID   A0A2K5WX31_MACFA        Unreviewed;       406 AA.
AC   A0A2K5WX31;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=Single Ig and TIR domain containing {ECO:0000313|Ensembl:ENSMFAP00000041673.2};
GN   Name=SIGIRR {ECO:0000313|Ensembl:ENSMFAP00000041673.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000041673.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000041673.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000041673.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC       {ECO:0000256|ARBA:ARBA00009752}.
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DR   AlphaFoldDB; A0A2K5WX31; -.
DR   Ensembl; ENSMFAT00000015949.2; ENSMFAP00000041673.2; ENSMFAG00000041564.2.
DR   VEuPathDB; HostDB:ENSMFAG00000041564; -.
DR   GeneTree; ENSGT01090000259985; -.
DR   OrthoDB; 5349166at2759; -.
DR   Proteomes; UP000233100; Chromosome 14.
DR   Bgee; ENSMFAG00000041564; Expressed in lymph node and 8 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015621; IL-1_rcpt_fam.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR   PANTHER; PTHR11890:SF19; SINGLE IG IL-1-RELATED RECEPTOR; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        119..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          9..109
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DOMAIN          163..303
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          336..386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..350
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  45078 MW;  D8B12D9E271B5C36 CRC64;
     MPGVCDKAPD FLSPSEDQVL RPALGSSVAL NCTAWVVSGP HCSLPSVQWL KDGLPLGNGG
     HYSLHEYSWD KANLSEVLVS SVLGINVTSA EVYGAFACSI QNVSSSSFTL QRAGPTSHVA
     AVLASLLVLL TLLLAALLYV KCRLNVLLWY QDAYGEVEMN DGKLYDAYVS YSDCPEDRKF
     VNFILKPQLE RRRGYKLFLD DLLAEPSADL LVNLSRCRRL IVVLSDAFLS RAWCSHSFRE
     GLCRLLELTR RPIFITFEGQ RRDPAHPALR LLRQHRHLVT LLLWRPGSVT PSSEFWKELQ
     LALPRKVHYR PVEGDPQTQL QDDKDPMLIL RGRVPEGRAL DSEVDPDPEG DLGVRGPVFG
     EPSAPPHTSG VSLGEGRSSE VDVSDLGSRN YSARTDFYCL VSKDDM
//
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