ID   A0A2K5WXF8_MACFA        Unreviewed;       545 AA.
AC   A0A2K5WXF8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Acyl-CoA thioesterase 7 {ECO:0000313|Ensembl:ENSMFAP00000041716.2};
GN   Name=ACOT7 {ECO:0000313|Ensembl:ENSMFAP00000041716.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000041716.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000041716.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000041716.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5WXF8; -.
DR   Ensembl; ENSMFAT00000015994.2; ENSMFAP00000041716.2; ENSMFAG00000041552.2.
DR   VEuPathDB; HostDB:ENSMFAG00000041552; -.
DR   GeneTree; ENSGT00940000155229; -.
DR   OrthoDB; 5393604at2759; -.
DR   Proteomes; UP000233100; Chromosome 1.
DR   Bgee; ENSMFAG00000041552; Expressed in temporal lobe and 13 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0036042; F:long-chain fatty acyl-CoA binding; IEA:Ensembl.
DR   GO; GO:0016290; F:palmitoyl-CoA hydrolase activity; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:Ensembl.
DR   GO; GO:0036116; P:long-chain fatty-acyl-CoA catabolic process; IEA:Ensembl.
DR   GO; GO:0051792; P:medium-chain fatty acid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0036114; P:medium-chain fatty-acyl-CoA catabolic process; IEA:Ensembl.
DR   GO; GO:1900535; P:palmitic acid biosynthetic process; IEA:Ensembl.
DR   CDD; cd03442; BFIT_BACH; 2.
DR   Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR   InterPro; IPR040170; Cytosol_ACT.
DR   InterPro; IPR033120; HOTDOG_ACOT.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   InterPro; IPR006683; Thioestr_dom.
DR   PANTHER; PTHR11049; ACYL COENZYME A THIOESTER HYDROLASE; 1.
DR   PANTHER; PTHR11049:SF34; CYTOSOLIC ACYL COENZYME A THIOESTER HYDROLASE; 1.
DR   Pfam; PF03061; 4HBT; 2.
DR   SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR   PROSITE; PS51770; HOTDOG_ACOT; 2.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01106};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Serine esterase {ECO:0000256|ARBA:ARBA00022487}.
FT   DOMAIN          215..333
FT                   /note="HotDog ACOT-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51770"
FT   DOMAIN          389..503
FT                   /note="HotDog ACOT-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51770"
FT   REGION          1..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          515..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..47
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        231
FT                   /evidence="ECO:0000256|PIRSR:PIRSR640170-1"
FT   ACT_SITE        420
FT                   /evidence="ECO:0000256|PIRSR:PIRSR640170-1"
SQ   SEQUENCE   545 AA;  58735 MW;  874095ED5724370C CRC64;
     MRATGAGVGW GGGGNRARLP GTRAAPSALT SSGRPGTGRS SESPARAAGN AQHKYLPPRG
     ERGPKSAPLR HLGRPGRFPP DCHRVGRGCR GSRAFSPAAR PNRHRTFWKR RPPGPSRRQN
     RTPARARGSL GGLGGGARGG AGAGRDRRGE AAFDSPRRAG PASTAPSLHL RPPPFMARPG
     LIHSSPGLPD TCALLQPPAA SASATPSMSG PDVETPSAIQ ICRIMRPDDA NVAGNVHGGT
     ILKMIEEAGA IISTRHCNSQ NGERCVAALA RVERTDFLSP MCIGEVAHVS AEITYTSKHS
     VEVQVNVMSE NILTGAKKLT NKATLWYVPL SLKNVDKVLE VPPVVYSRQE QEEEGRKRYE
     AQKLERMETK WRNGDIVQPV LNPEPNTVSY SQSSLIHLVG PSDCTLHGFV HGGVTMKLMD
     EVAGIVAARH CKTNIVTASV DAINFHDKIR KGCVITISGR MTFTSNKSME IEVLVDADPV
     VDSSQKRYRA ASAFFTYVSL SQEGRSLPVP QLVPETEDEK KRFEEGKGRY LQMKAKRQGH
     TEPQP
//