ID A0A2K5X129_MACFA Unreviewed; 624 AA.
AC A0A2K5X129;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Basic helix-loop-helix ARNT-like protein 1 {ECO:0000256|ARBA:ARBA00041169};
DE AltName: Full=Aryl hydrocarbon receptor nuclear translocator-like protein 1 {ECO:0000256|ARBA:ARBA00042144};
DE AltName: Full=Brain and muscle ARNT-like 1 {ECO:0000256|ARBA:ARBA00041751};
GN Name=BMAL1 {ECO:0000313|Ensembl:ENSMFAP00000043178.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000043178.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000043178.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000043178.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
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DR AlphaFoldDB; A0A2K5X129; -.
DR Ensembl; ENSMFAT00000017468.2; ENSMFAP00000043178.2; ENSMFAG00000034184.2.
DR VEuPathDB; HostDB:ENSMFAG00000034184; -.
DR GeneTree; ENSGT00940000157523; -.
DR OrthoDB; 2872674at2759; -.
DR Proteomes; UP000233100; Chromosome 14.
DR Bgee; ENSMFAG00000034184; Expressed in thymus and 13 other cell types or tissues.
DR GO; GO:1990513; C:CLOCK-BMAL transcription complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0017162; F:aryl hydrocarbon receptor binding; IEA:Ensembl.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0070888; F:E-box binding; IEA:Ensembl.
DR GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:Ensembl.
DR GO; GO:0042753; P:positive regulation of circadian rhythm; IEA:Ensembl.
DR GO; GO:1901985; P:positive regulation of protein acetylation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0042634; P:regulation of hair cycle; IEA:Ensembl.
DR GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR CDD; cd11438; bHLH-PAS_ARNTL_PASD3; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23042:SF52; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 70..123
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 141..206
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 345..394
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 456..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 68856 MW; 0DF1957FA98DA0A6 CRC64;
MSKEAVSLWA HTVSLQPPIP LCVCREMTGS GRRKQQCVTL PFISRELCFY LLLFPPSRLE
YTEHQGRIKN AREAHSQIEK RRRDKMNSFI DELASLVPTC NAMSRKLDKL TVLRMAVQHM
KTLRGATNPY TEANYKPTFL SDDELKHLIL RAADGFLFVV GCDRGKILFV SESVFKILNY
SQNDLIGQSL FDYLHPKDIA KVKEQLSSSD TAPRERLIDA KTGLPVKTDI TPGPSRLCSG
ARRSFFCRMK CNRPSVKVED KDFPSTCSKK KADRKSFCTI HSTGYLKSWP PTKMGLDEDN
EPDNEGCNLS CLVAIGRLHS HVVPQPVNGE IRVKSMEYVS RHAIDGKFVF VDQRATAILA
YLPQELLGTS CYEYFHQDDI GHLAECHRQV LQTREKITTN CYKFKIKDGS FITLRSRWFS
FMNPWTKEVE YIVSTNTVVL ANVLEGGDPT FPQLTASPHS MDSMLPSGEG GPKRTHPTVP
GIPGGTRAGA GKIGRMIAEE IMEIHRIRGS SPSSCGSSPL NITSTPPPDA SSPGGKKILN
GGTPDIPSSG LLSGQAQENP GYPYSDSSSI LGENPHIGID MIDNDQGSSS PSNDEAAMAV
IMSLLEADAG LGGPVDFSDL PWPL
//
