ID A0A2K5X267_MACFA Unreviewed; 2179 AA.
AC A0A2K5X267;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Bromodomain adjacent to zinc finger domain 2B {ECO:0000313|Ensembl:ENSMFAP00000043579.2};
GN Name=BAZ2B {ECO:0000313|Ensembl:ENSMFAP00000043579.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000043579.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000043579.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000043579.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WAL family. {ECO:0000256|ARBA:ARBA00007444}.
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DR Ensembl; ENSMFAT00000017869.2; ENSMFAP00000043579.2; ENSMFAG00000037367.2.
DR VEuPathDB; HostDB:ENSMFAG00000037367; -.
DR GeneTree; ENSGT00940000155359; -.
DR OrthoDB; 2912910at2759; -.
DR Proteomes; UP000233100; Chromosome 12.
DR Bgee; ENSMFAG00000037367; Expressed in lung and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd05503; Bromo_BAZ2A_B_like; 1.
DR CDD; cd01397; HAT_MBD; 1.
DR CDD; cd15630; PHD_BAZ2B; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR037374; BAZ2A/B_Bromo.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45915:SF1; BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B; 1.
DR PANTHER; PTHR45915; TRANSCRIPTION INTERMEDIARY FACTOR; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF00628; PHD; 1.
DR Pfam; PF15613; WSD; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS50982; MBD; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 740..815
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT DOMAIN 1063..1128
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 1942..1992
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2088..2158
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1479..1518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1558..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1645..1670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2009..2051
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..179
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..288
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..350
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..661
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1275..1296
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1645..1667
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2179 AA; 241345 MW; 1ED139C16AFAEF07 CRC64;
MESGERLPSS AASSTTPTSS STPSVASVVS KGGLSTGVAS LSSTINPCGH LFRTAGDQPF
NLSTVSSAFP MVSHPVFGLH SASSGHSEFG GLGTLGTPTA LAAHPQLASF PGAEWWRTTD
AHTRTGATFF PPLLGIPPLF APPAQNHDSS SFHSRTSGKS NRNGPEKGVN GSINGNNTSS
VIGINTSVLS TTASSSMGQT KSTSSGGGNR KCNQEQSKNQ PLDARVDKIK DKKPRKKAME
SSSNSDSDSG TSSDTSSEGI SSSDSDDLEE DEEEEDQSIE ESEDDDSDSE SEAQHKSNNQ
VLLHGISDPK ADGQKATEKA QEKRIHQPLP LVSESQTHSS FQSQQKQPQV LSQQLPFIFQ
SSQAKEESVN KHTSVIQSTG LVSNVKPLSL VNQAKKETYM KLIVPSPDVL KAGNKNTSEE
SSSLTSELRS KREQYKQAFP SQLKKQESSK SLKKVIAALS NPKATSSSPA HPKQILENNH
PNPFLTNALL GNHQPNGVIQ SVIQEAPLAL TTKTKMQSKI NENIAAASST PFSSPVNLST
SGRRTPGNQT PVMPSASPIL HSQGKEKAVS NNVNPVKTQR HSHPAKPLVE QFRGTDSDIP
SSKDSEDSNE DEEEDDEEED EEDDDDDESD DSQSESDSNS ESDTEGSEEE DDDDKDQDES
DSDTEGEKTS MKLNKTTSSV KSPSMSLTAH STPRNLHIAK APGSAPAALC SESQLPAFLG
TSSSTLTSSP HSGTSKRRRV TDERELRIPL EYGWQRETRI RNFGGRLQGE VAYYAPCGKK
LRQYPEVIKG MQWCLLKEED VIPRIRAMEG RRGRPPNPDR QRAREESRMR RRKGRPPNVG
NAEFLDNTDA KLLRKLQAQE IARQAAQIKL LRKLQKQEQA RVAKEAKKQQ AIMAAEEKRK
QKEQIKIMKQ QEKIKRIQQI RMEKELRAQQ ILEAKKKKKE EAANAKLLEA EKRIKEKEMR
RQQAVLLKHQ ELERHRLDME RERRRQHMML MKAMEARKKA EEKERLKQEK RDEKRLNKER
KLEQRRLELE MAKELKKPNE DMCLADQKPL PELPRIPGLV LSGSTFSDCL MVVQFLRNFG
KVLGFDVNID VPNLSVLQEG LLNIGDSMGE VQDLLVRLLS AAVCDPGLIT GYKAKTALGE
HLLNVGVNRD NVSEILQIFM EAHCGQTELT ESLKTKAFQA HTPAQKASVL AFLINELACS
KSVVSEIDKN IDYMSNLRRD KWVVEGKLRK LRIIHAKKTG KRDTSSGIDL GEEQHPLGTP
TPGRKRRRKG GDSDYDDDDD DDSDDQGDED DEDEEDKEDK KGKKTDICED EDEGDQAASV
EELEKQIEKL SKQQSQYRRK LFDASHSLRS VMFGQDRYRR RYWILPQCGG IFVEGMESGE
GLEEIAKERE KLKKAESVQI KEEMFETSGD SLNCSNTDHC EQKEDLKEKD NTNLFLQKPG
SFSKLSKLLE VAKMPPESEV ITPKPNAGAN GCTLSYQNSG KHSLGSVQST ATQSNVEKAD
SNNLFNTGSS GPGKFYSPLP SDQLLKTLTE KNRQWFSLLP RTPCDDTSLT HADMSTASLV
TPQSQPPSKS PSPAPAPLGS STQNPVGLNP FALSPLQVKG GVSMMGLQFC GWPTGVLTSN
IPFASSVPGL GSGLGLSEGN GNSLLTSTVA SSKSESPVPQ NEKATSAQPA AVEVAKPVDF
PSPKPIPEEM QFGWWRIIDP EDLKALLKVL HLRGIREKAL QKQIQKHLDY ITQACIKNKD
VAIIELNENE ENQVTRDIVE NWSVEEQAME MDLSVLQQVE DLERRVASAS LQVKGWMCPE
PASEREDLVY FEHKSFTKLC KEHDGEFTGE EESSAHALER KSDNPLDIAV TRLADLERNI
ERRYLKSPLS TTIQIKLDNV GTVTVPAPAP SISGDGDGIE EDIAPGLRVW RRALSEARSA
AQVALCIQQL QKSIAWEKSI MKVYCQICRK GDNEELLLLC DGCDKGCHTY CHRPKITTIP
DGDWFCPACI AKASGQTLKI KKLHVKGKKT NESKKGKKVT LTGDTEDEDS ASTSSSLKRG
NKDLKKRKME ENTSINLSKQ ESFTSVKKPK RDDSKDLALC SMILTEMETH EDAWPFLLPV
NLKLVPGYKK VIKKPMDFST IREKLSSGQY PNLETFALDV RLVFDNCETF NEDDSDIGRA
GHNMRKYFEK KWTDTFKVS
//
