ID A0A2K5X270_MACFA Unreviewed; 652 AA.
AC A0A2K5X270;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Forkhead box P1 {ECO:0000313|Ensembl:ENSMFAP00000043366.2};
GN Name=FOXP1 {ECO:0000313|Ensembl:ENSMFAP00000043366.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000043366.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000043366.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000043366.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A2K5X270; -.
DR Ensembl; ENSMFAT00000017656.2; ENSMFAP00000043366.2; ENSMFAG00000033964.2.
DR VEuPathDB; HostDB:ENSMFAG00000033964; -.
DR GeneTree; ENSGT00940000159892; -.
DR Proteomes; UP000233100; Chromosome 2.
DR Bgee; ENSMFAG00000033964; Expressed in lymph node and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20065; FH_FOXP2; 1.
DR Gene3D; 1.20.5.340; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047412; FH_FOXP1_P2.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR032354; FOXP-CC.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45796; FORKHEAD BOX P, ISOFORM C; 1.
DR PANTHER; PTHR45796:SF3; FORKHEAD BOX PROTEIN P1; 1.
DR Pfam; PF00250; Forkhead; 1.
DR Pfam; PF16159; FOXP-CC; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 440..513
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 440..513
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 231..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 73356 MW; 09739786A4EE425B CRC64;
MPVDIGAADL AHAQQQQQQA LQVARQLLLQ QQQQQQVSGL KSPKRNDKQP ALQVPVSVAM
MTPQVITPQQ MQQILQQQVL SPQQLQVLLQ QQQALMLQQQ QLQEFYKKQQ EQLQLQLLQQ
QHAGKQPKEQ QQVATQQLAF QQQLLQMQQL QQQHLLSLQR QGLLTIQPGQ PALPLQPLAQ
GMIPTELQQL WKEVTSAHTA EETTSNNHSS LDLTTTCVSS SAPSKTSLIM NPHASTNGQL
SVHTPKRERQ SRRTYTEKRR LMHLSLSHEE HPHSHPLYGH GVCKWPGCEA VCEDFQSFLK
HLNSEHALDD RSTAQCRVQM QVVQQLELQL AKDKERLQAM MTHLHVKSTE PKAAPQPLNL
VSSVTLSKSA SEASPQSLPH TPTTPTAPLT PVTQGPSVIT TTSMHTVGPI RRRYSDKYNV
PISSADIAQN QEFYKNAEVR PPFTYASLIR QAILESPEKQ LTLNEIYNWF TRMFAYFRRN
AATWKNAVRH NLSLHKCFVR VENVKGAVWT VDEVEFQKRR PQKISGNPSL IKNMQSSHAY
CTPLNAALQA SMAENSIPLY TTASMGNPTL GNLASAIREE LNGAMEHTNS NESDSSPGRS
PMQAVHPVHV KEEPLDPEEA EGPLSLVTTA NHSPDFDHDR DYEDEPVNED ME
//
