ID A0A2K5X2U2_MACFA Unreviewed; 746 AA.
AC A0A2K5X2U2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=N-acetyl-alpha-glucosaminidase {ECO:0000313|Ensembl:ENSMFAP00000043592.2};
GN Name=NAGLU {ECO:0000313|Ensembl:ENSMFAP00000043592.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000043592.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000043592.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000043592.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
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DR AlphaFoldDB; A0A2K5X2U2; -.
DR STRING; 9541.ENSMFAP00000043592; -.
DR Ensembl; ENSMFAT00000017883.2; ENSMFAP00000043592.2; ENSMFAG00000039206.2.
DR VEuPathDB; HostDB:ENSMFAG00000039206; -.
DR GeneTree; ENSGT00390000005900; -.
DR OrthoDB; 1112009at2759; -.
DR Proteomes; UP000233100; Chromosome 16.
DR Bgee; ENSMFAG00000039206; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0043202; C:lysosomal lumen; IEA:Ensembl.
DR GO; GO:0004561; F:alpha-N-acetylglucosaminidase activity; IEA:Ensembl.
DR GO; GO:0030534; P:adult behavior; IEA:Ensembl.
DR GO; GO:0042982; P:amyloid precursor protein metabolic process; IEA:Ensembl.
DR GO; GO:0035909; P:aorta morphogenesis; IEA:Ensembl.
DR GO; GO:0048143; P:astrocyte activation; IEA:Ensembl.
DR GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR GO; GO:0055013; P:cardiac muscle cell development; IEA:Ensembl.
DR GO; GO:0044242; P:cellular lipid catabolic process; IEA:Ensembl.
DR GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR GO; GO:0021680; P:cerebellar Purkinje cell layer development; IEA:Ensembl.
DR GO; GO:0032963; P:collagen metabolic process; IEA:Ensembl.
DR GO; GO:1904390; P:cone retinal bipolar cell differentiation; IEA:Ensembl.
DR GO; GO:0007028; P:cytoplasm organization; IEA:Ensembl.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
DR GO; GO:0003158; P:endothelium development; IEA:Ensembl.
DR GO; GO:0035640; P:exploration behavior; IEA:Ensembl.
DR GO; GO:0001573; P:ganglioside metabolic process; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
DR GO; GO:0030200; P:heparan sulfate proteoglycan catabolic process; IEA:Ensembl.
DR GO; GO:0030201; P:heparan sulfate proteoglycan metabolic process; IEA:Ensembl.
DR GO; GO:0030202; P:heparin metabolic process; IEA:Ensembl.
DR GO; GO:0042445; P:hormone metabolic process; IEA:Ensembl.
DR GO; GO:0060119; P:inner ear receptor cell development; IEA:Ensembl.
DR GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR GO; GO:0060173; P:limb development; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0045475; P:locomotor rhythm; IEA:Ensembl.
DR GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR GO; GO:0035633; P:maintenance of blood-brain barrier; IEA:Ensembl.
DR GO; GO:0014004; P:microglia differentiation; IEA:Ensembl.
DR GO; GO:0001774; P:microglial cell activation; IEA:Ensembl.
DR GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
DR GO; GO:0003183; P:mitral valve morphogenesis; IEA:Ensembl.
DR GO; GO:0061744; P:motor behavior; IEA:Ensembl.
DR GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0021675; P:nerve development; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0016485; P:protein processing; IEA:Ensembl.
DR GO; GO:0097696; P:receptor signaling pathway via STAT; IEA:Ensembl.
DR GO; GO:0034285; P:response to disaccharide; IEA:Ensembl.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0009611; P:response to wounding; IEA:Ensembl.
DR GO; GO:0046548; P:retinal rod cell development; IEA:Ensembl.
DR GO; GO:1904389; P:rod bipolar cell differentiation; IEA:Ensembl.
DR GO; GO:0097577; P:sequestering of iron ion; IEA:Ensembl.
DR GO; GO:0006801; P:superoxide metabolic process; IEA:Ensembl.
DR GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:Ensembl.
DR GO; GO:0099022; P:vesicle tethering; IEA:Ensembl.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 1.20.120.670; N-acetyl-b-d-glucoasminidase; 1.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR007781; NAGLU.
DR InterPro; IPR024732; NAGLU_C.
DR InterPro; IPR024240; NAGLU_N.
DR InterPro; IPR024733; NAGLU_tim-barrel.
DR PANTHER; PTHR12872; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR12872:SF1; ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR Pfam; PF05089; NAGLU; 1.
DR Pfam; PF12972; NAGLU_C; 1.
DR Pfam; PF12971; NAGLU_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..746
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030052542"
FT DOMAIN 32..118
FT /note="Alpha-N-acetylglucosaminidase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12971"
FT DOMAIN 133..468
FT /note="Alpha-N-acetylglucosaminidase tim-barrel"
FT /evidence="ECO:0000259|Pfam:PF05089"
FT DOMAIN 477..735
FT /note="Alpha-N-acetylglucosaminidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12972"
SQ SEQUENCE 746 AA; 83015 MW; BF4124BA5128D49E CRC64;
QQGRPEVTFL IVLLLAGFDR RGAADDEARE AAAVRALVAR LLGPGPAADF SVSVERALAT
KPGLDTYSLG GGGAARVRVR GSTGVAAAAG LHRYLRDFCG CHVAWSGSQL RLPRPLPAVV
GCAPAHDTAR RYRYYQNVCT QSYSFVWWDW ARWEREIDWM ALNGINLALA WSGQEAIWQR
VYLALGLTQT EINEFFTGPA FLAWGRMGNL HTWDGPLPPS WHIKQLYLQH RVLDRMRSFG
MTPVLPAFAG HVPEAVTRVF PQVNVTKMGS WGHFNCSYSC SFLLAPEDPM FPVIGSLFLR
ELVKEFGTDH IYGADTFNEM QPPSSAPSYL AAATTAVYEA MIAVDTEAVW LLQGWLFQHQ
PQFWGPAQIG AVLGAVPRGR LLVLDLFAES QPVYTRTASF QGQPFIWCML HNFGGNHGLF
GALEAVNGGP EAARLFPNST MVGTGMAPEG ISQNEVVYSL MAELGWRKDP VPDLAAWVTN
FAAQRYGVSH PDAGAAWRLL LRSVYNCSGE ACRGHNRSPL VRRPSLQMNT SVWYNRSSVF
EAWRLLLTSA PSLAASPAFR YDLLDLTRQA VQELVSLYYE EARSAYLSKE LTSLLRAGGV
LAYELLPALD ELLASDSRFL LGSWLEQARA AAVSEAEADF YEQNSRYQLT LWGPEGNILD
YANKQLAGLV ANYYTPRWRL FLEALADSVA QGIPFQQHQF DKNVFQLEQA FVLSKQRYPS
QPRGDTVDLA KKIFLKYYPR WVAGSW
//
