ID A0A2K5X576_MACFA Unreviewed; 476 AA.
AC A0A2K5X576;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 5 {ECO:0000313|Ensembl:ENSMFAP00000044460.2};
GN Name=PCSK5 {ECO:0000313|Ensembl:ENSMFAP00000044460.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000044460.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000044460.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000044460.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5X576; -.
DR Ensembl; ENSMFAT00000018754.2; ENSMFAP00000044460.2; ENSMFAG00000039542.2.
DR VEuPathDB; HostDB:ENSMFAG00000039542; -.
DR GeneTree; ENSGT00940000155770; -.
DR OrthoDB; 5474719at2759; -.
DR Proteomes; UP000233100; Chromosome 15.
DR Bgee; ENSMFAG00000039542; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR010909; PLAC.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF7; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF08686; PLAC; 1.
DR SMART; SM00261; FU; 5.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS50900; PLAC; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 24..164
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT DOMAIN 432..476
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
SQ SEQUENCE 476 AA; 53468 MW; 59B51777D060CBC0 CRC64;
MSHLYGFGLM DAEAMVMEAE KWTTVPRQHV CVESTDRQIK TIRPNSAVRS IYKASGCSDN
PNRHVNYLEH VVVRITITHP RRGDLAIYLT SPSGTRSQLL ANRLFDHSME GFKNWEFMTI
HCWGERAAGD WVLEVYDTPS QLRNFKTPGK LKEWSLVLYG TSVQPYSPTN EFPKVERFRY
SRVEDPTDDY GTEDYAGPCD PECSEVGCDG PGPDHCNDCL HYYYKLKNNT RICVSGCPPG
HYHADRKRCR KCAPNCESCF GSHGEQCLSC KYGYFLNEET NSCVTHCPDG SYQDTKKNLC
RKCSENCKTC TEFHNCTECR DGLSLQGSRC SVSCEDGRYF NGQDCQPCHR FCATCAGAGA
DGCINCTEGY FMEDGRCVQS CSISYYFDHS SENGYKSCKK CDTSCLTCNG PGFKNCTSCP
SGYLLDLGMC QMGAICKDAT EESWAEGGFC MLVKKNNLCQ RKVLQQLCCK TCTFQG
//
