ID A0A2K5X591_MACFA Unreviewed; 1820 AA.
AC A0A2K5X591;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Latent transforming growth factor beta binding protein 2 {ECO:0000313|Ensembl:ENSMFAP00000044475.2};
GN Name=LTBP2 {ECO:0000313|Ensembl:ENSMFAP00000044475.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000044475.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000044475.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000044475.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 9541.ENSMFAP00000044475; -.
DR Ensembl; ENSMFAT00000018769.2; ENSMFAP00000044475.2; ENSMFAG00000039527.2.
DR VEuPathDB; HostDB:ENSMFAG00000039527; -.
DR GeneTree; ENSGT00940000160884; -.
DR Proteomes; UP000233100; Chromosome 7.
DR Bgee; ENSMFAG00000039527; Expressed in lung and 6 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019838; F:growth factor binding; IEA:UniProtKB-KW.
DR GO; GO:0097435; P:supramolecular fiber organization; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.10; Laminin; 19.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR47333:SF2; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF07645; EGF_CA; 17.
DR Pfam; PF00683; TB; 4.
DR SMART; SM00181; EGF; 20.
DR SMART; SM00179; EGF_CA; 18.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 12.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 14.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..1820
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030052591"
FT DOMAIN 186..218
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 395..427
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 551..594
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 621..661
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 671..723
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 843..881
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 886..922
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 929..968
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1009..1049
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1134..1174
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1175..1216
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1217..1252
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1302..1343
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1410..1462
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1484..1526
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1527..1562
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1583..1635
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1773..1817
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 89..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 190..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 208..217
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 399..409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 417..426
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1531..1541
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1820 AA; 195541 MW; B9D94364061C0BE6 CRC64;
MRPRTKARSP GRAPWNPWRG FLPLTLAFFV GAGHAQRDPV GRYEPAGGDA NRLRRPGSYP
AAAAAKVYSL FREQDASVAD LPPVERAQLG WGIPRRPTET EARRPSRAQQ SRRVQPPAQT
RRSTPLGQQQ PAPRARAAPA LPRLGIPRRS GAAPPTPPRG RLTGRNVCGG QCCPGWTTAN
STNHCIKPVC QPPCQNRGSC SRPQLCVCRS GFRGARCEEV IPDEEFDPQN SRVAPRRWAE
RSPNLRRSSA AGDGTLARAQ PPAPQSPPVP QSPPAGTLSD LSQTHPSQQH VGLSRTVRLH
PTATVSSQLS SNALPPGPGL EQRDGTQQVV PLEHPSSPWG LNLTEKIKKI KIVFTPTICK
QTCARGHCAN SCERGDTTTL YSQGGHGHDP KSGFRIYFCQ IPCLNGGRCI GRDECWCPAN
STGKFCHLPI PQPDREPPGR GSRSRALLEA PLRHSTFTLP LSNQLASVNP SLVKVHIHHP
PEASVQIHQV ARVRGGVEEA LEENSVETRP PPWLPASPGH SLWDSNNIPA RSGEPPRPLP
PAAPRPRGLL GRCYLNTVNG QCANPLLELT TQEDCCGSVG AFWGVTLCAP CPPRPASPVI
ENGQLECPQG YKRLNLTHCQ DINECLTLGL CKDAECVNTR GSYLCTCRPG LMLDPSRSRC
VSDKAISMLQ GLCYRSLGPD TCTLPLAQRI TKQICCCSRV GKAWGSECEK CPLPGTEAFR
EICPAGHGYT YASSDIRLSM RKAEEEELAR PPREQGQRSS GALPGPADRQ PLRVITDTWL
EAGTVPDKGD SQAGQVTTSV THTPAWVTGN ATTPPMPEQG IPEIQEEQVT PSTDMLVTLS
TPGIDRCAAG ATNICGPGTC VNLPDGYRCV CSPGYQLHPS QAYCMDDNEC LRDPCRGKGR
CINRVGSYSC FCYPGYTLAT SEATQECQDI NECEQPGVCS GGQCTNTEGS YHCECDQGYI
MVRKGHCQDI NECRHPGTCP DGRCVNSPGS YTCLACEEGY RGQSGSCVDV NECLTPGVCA
HGKCTNLEGS FRCSCEQGYE VTSHEKGCQD VDECANRASC PTGLCLNTEG SFTCSACESG
YWVNEDGTAC EDLDECAFPG VCPSGVCTNT AGSFSCKDCD GGYRPSPLGD SCEDVDECED
PQGSCLGGEC KNTAGSYQCL CPQGFQLANG TLCEDVNECM GEEHCAPHGE CLNSHGSFFC
LCAPGFVSAE GGTSCLDVDE CAATDPCLGG HCVNTEGSFN CLCETGFQPS PESGECVDID
ECEDYGDPVC GAWKCENSPG SYRCVLGCQP GFHMAPNGDC IDIDECTNDT MCGSHGFCDN
TDGSFRCLCD QGFEISPSGW DCVDVNECEL MLAVCGAALC ENVEGSFLCL CASDLEEYDA
QEGHCRPRGA GGQSIPEAPT GDHAPAPTRM DCYSGQNGHA PCSSVLGQNT TQAECCCTQG
ASWGEACDLC PSEDSAEFSE ICPSGKGYIP VEGAWTFGQT MYTDADECVI FGPGLCPNGR
CLNTVPGYVC LCNPGFHYDA SHRKCEDHDE CQDLACENGE CVNTEGSFHC FCSPPLTLDL
SQQRCMNSTS STEDLPDHDI HMDVCWKKVT NDVCSEPLRG HRTTYTECCC QDGEAWSQQC
ALCPPRSSEV YAQLCNVARI EAEREAGVHF RPGYEYGPGP DDLHYSIYGP DGAPFYNYLG
PEDTVPEPAF PNTAGHPGDR TPILESPLQP SELQPHYVAS HPEAPAGFEG LQAEECGILN
GCENGRCVRV REGYTCDCFE GFQLDAAHMA CVDVNECDDL NGPAVLCVHG YCENTEGSYR
CHCSPGYVAE AGPPHCTAKE
//
