ID A0A2K5X9U0_MANLE Unreviewed; 593 AA.
AC A0A2K5X9U0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Leucine rich repeat and Ig domain containing 4 {ECO:0000313|Ensembl:ENSMLEP00000000091.1};
GN Name=LINGO4 {ECO:0000313|Ensembl:ENSMLEP00000000091.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000000091.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000000091.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011828899.1; XM_011973509.1.
DR RefSeq; XP_011828900.1; XM_011973510.1.
DR AlphaFoldDB; A0A2K5X9U0; -.
DR STRING; 9568.ENSMLEP00000000091; -.
DR Ensembl; ENSMLET00000000167.1; ENSMLEP00000000091.1; ENSMLEG00000000178.1.
DR GeneID; 105534712; -.
DR KEGG; mleu:105534712; -.
DR CTD; 339398; -.
DR GeneTree; ENSGT00940000162157; -.
DR OMA; CAHRRLE; -.
DR OrthoDB; 2911036at2759; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24373:SF156; LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 4; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13855; LRR_8; 4.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..593
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014467564"
FT TRANSMEM 532..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 412..502
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 593 AA; 63840 MW; 129AD0FCE7947298 CRC64;
MDAATAPKQA WPPWPPLLFL LLLTGGSGGS CPAVCDCTSQ PQAVLCGHRQ LEAVPGGLPL
DTELLDLSGN RLWGLQRGML SRLSLLQELD LSYNQLSTLE PGAFHGLQSL LTLRLQGNRL
RIMGPGVFSG LSALTLLDLR LNQIVLFLDG AFGELGSLQK LEVGDNHLVF VAPGAFAGLA
KLSTLTLERC NLSTVPGLAL ARLPALVALR LRELDIGRLP AGALRGLGQL KELEIHHWPS
LEALDPGSLV GLNLSSLAIT RCNLSSVPFQ ALHHLSFLRV LDLSQNPISA IPARRLSPLV
RLQELRLSGA CLTSIAAHAF HGLTAFHLLD VADNALQTLE ETAFPSPDKL VTLRLSGNPL
TCDCRLLWLL RLRRRLDFGT SPPACAGPQH VQGKSLREFS DILPPGHFTC KPALIRKSGP
RWVIAEEGGH AVFSCSGDGD PAPTVSWMRP HGAWLGRAGR VRVLEDGTLE IRSVQLRDRG
AYVCVVSNVA GNDSLRTWLE VIQVEPPNGT LSDPNITVPG IPGPFFLDSR GVAMVLAVGF
LPFLTSVTLC FGLIALWSKG KGRVKHHMTF DFVAPRPSGD RNSGGNRVTA KLF
//
