ID A0A2K5X9U4_MANLE Unreviewed; 543 AA.
AC A0A2K5X9U4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Zinc finger protein 77 {ECO:0000313|Ensembl:ENSMLEP00000000094.1};
GN Name=ZNF77 {ECO:0000313|Ensembl:ENSMLEP00000000094.1};
OS Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Mandrillus.
OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000000094.1, ECO:0000313|Proteomes:UP000233140};
RN [1] {ECO:0000313|Ensembl:ENSMLEP00000000094.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC {ECO:0000256|ARBA:ARBA00003767}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; A0A2K5X9U4; -.
DR STRING; 9568.ENSMLEP00000000094; -.
DR Ensembl; ENSMLET00000000181.1; ENSMLEP00000000094.1; ENSMLEG00000000151.1.
DR GeneTree; ENSGT00940000162830; -.
DR OMA; HQCGETW; -.
DR Proteomes; UP000233140; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 12.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR19818:SF168; GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED; 1.
DR PANTHER; PTHR19818; ZINC FINGER PROTEIN ZIC AND GLI; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR Pfam; PF13894; zf-C2H2_4; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 7.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 3..76
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 210..237
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 238..265
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 266..293
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 294..321
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 322..349
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 350..377
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 378..405
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 406..433
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 434..461
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 462..489
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 490..517
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 518..543
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 543 AA; 61650 MW; A642631C7EDFA2C4 CRC64;
DSVVFEEVAV NFTPEEWALL DHAQRSLYRD VMLETCRNLA SLDCCIYVRT CGSSSQRDVL
GNGISNDEEI VKFTSDYWSI FGENWRFDNT GDQHQIPERH LRSQLGSLCE SNEGHQCGET
WSQTANLPVH KSYPTEAQPS ECTKCGKASE NQQRSHTRQR LCKECGQACS CLSCQSPPMK
TQTVEKPCNG QDSGRASATY VKSLSSKKSY ECKKCGKAFA CPSSFRGHVN SHHEQKTHAC
KVCGKTFMYY SYLTRHLRTH TGEKPYECKE CGKAFSCPSY FREHVRTHTG EKPYECKHCG
KSFSCYSSFR DHVRTHTGEK PCQCKHCGKA FTCYSSLREH GRTHSGEKPY ECKECGKAFR
YPSSLRAHVR MHTGEKPYVC KQCGKAFGCP TYFRRHVKTH SGVKPYECKE CGKAYSFSSS
LRIHVRTHTG EKPFECKHCG KAFSCHSSLR EHVRTHSGEK PYECNQCGKA FSHAQYFQKH
VRSHSGVKPY ECPECGKAYS CSSSLRVHVR THTGERPYEC KQCGKTFRYL ASLQAHVRTH
AGA
//
